哮喘的

This book provides a comprehensive review of clinically relevant topics in occupational asthma written by nationally and internationally recognized experts in the field. This text is an outstanding reference resource for the clinician, clinical scientist or clinical fellow with an interest in workrelated asthma.

本书是职业性哮喘领域多位国内和国际知名专家在各个临床相关课题方面的全面深入的总结，是对职业性哮喘感兴趣的临床医生，临床科学家或低年资临床医生的优秀参考书。

PART FOUR EFFECTS OF MIL-4RA EXPRESSION VECTOR ON ASTHMATIC AIRWAY INFLAMMATION AND TH1/TH2 CELL DISFUNCTION THROUGH INTRAPERITONEAL ADMINISTRATION In the study of part three, we treated the mouse asthmatic model by intratracheal administration with mIL-4RA expression plasmid and observed obvious therapeutic effects. But intratracheal administration belongs to one of the insult therapies.

第四部分：腹腔注射mIL-4RA重组载体对哮喘小鼠气道炎症及Th失衡的干预作用前一部分研究中我们通过气道局部干预途径，即气管内直接滴注的方式，观察到mIL-4RA真核表达质粒对哮喘小鼠具有很好的治疗作用，但气管内滴注毕竟属有创性治疗，存在需要实验条件高，有较大的风险性，不易反复进行等缺点，这势必大大限制其在动物实验及进一步临床研究中的实际应用价值。

Objective: To measure the variation and significance of respiratory impedance and pulmonary ventilation function in patients with bronchial asthma by impulse oscillometry before or after the bronchial provocation test, investigate the relationship between the IOS method and bronchial provocation test, and evaluate the clinical significance in bronchial asthma by IOS method.

目的：应用脉冲振荡法测定支气管哮喘患者在支气管激发试验前后的呼吸阻抗及肺通气功能参数的变化规律和临床意义，探讨IOS测定方法能否作为支气管激发试验的判断方法以及IOS测定参数在哮喘诊断中的价值。

Methods: We examined the relations among selected familial andenvironmental factors, markers of allergy, spirometric measuresof lung function, and AHR in a cross-sectional study of 403Costa Rican children with asthma between the ages of 6 and 14years.

鉴于对西班牙美国地区儿童哮喘中气道高反应性的决定因素方面的了解很少，Ly等人对403例Costa Rican哮喘儿童（年龄6～14岁）进行了横向研究，在此研究中我们检测了某些家族和环境因素、过敏标志物、肺功能中肺量计的指标以及气道高反应性间的关系。

With computer image analysis system, the expressions of NF-κB and ICAM-1 and subepithelial collagen deposition were checked.

将40只大鼠随机分为对照组、哮喘组（以卵蛋白激发的大鼠哮喘模型）、布地耐德早期治疗组、布地耐德晚期治疗组，应用免疫组化技术结合计算机病理图像分析系统测定大鼠气道上皮胶原的沉积和气道上皮细胞NF-κB、ICAM-1的相对含量。

Results Observation of 35 746 grain of airborne fungi spores and 1 188 grain of fungi spores for one year revealed the following species of fungi: Ustilaginales, Aternaria, Uredinales, Clodoporium cladosporioides, Cladosporium, Pithomyces, Cladosporium macrocarpum, Aspergillus niger, Aspergillus versicolor and Aspergillus fumigatus. Thirth-nine of 85 infants and young children with asthma (45.9%) showed positive skin test and 108 of 260 older children with asthma (41.5%) were positive for the skin tests; total positive rate was 42.61%.

结果 经1年的调查，曝片观察到的35 746个真菌孢子和曝皿观察到的1 188个菌落，分属于4个亚门60个种属，常见菌种有黑粉菌、交链孢菌、锈菌、枝孢芽枝菌、芽枝菌、皮思菌、大孢枝孢菌、黑曲菌、杂曲菌和烟曲菌。85例婴幼儿哮喘患儿，39例真菌变应原皮内试验阳性（45.9％），260例儿童哮喘患儿，108例皮试阳性（41.5％），总阳性率42.6％。

OBJECTIVES: We tested the hypothesis that titrating corticosteroid dose using the concentration of exhaled nitric oxide in exhaled breath Fe(NO results in fewer asthma exacerbations and more efficient use of corticosteroids, when compared with traditional management.

Dominick等设计本实验以期验证一个新的假说：与传统管理方法相比，以测定哮喘患者呼出气NO的浓度来调整糖皮质激素的剂量可减少哮喘急性发作并使激素的使用更有效。

Odds ratios were calculated for the association between childhood adiposity, expressed as 'overweight' or as BMI z-score quartiles at 7 yrs of age, and asthma development after that age.

研究发现，在女性人群中，成年哮喘（21岁后发病，32岁仍存在的哮喘）与7岁时的肥胖程度有明显的相关性，而且这种相关性不能以儿童肺功能或初潮年龄的差异来解释。

Several recent studies have indicated that a Mediterranean-style diet could help reduce asthma and hayfever symptoms in children, but "the effect of adherence to a Mediterranean diet on adult asthma outcomes is unknown," Renata Barros and colleagues explain in the journal Allergy.

Renata Barros和他的同事们发表在《Allergy》杂志上称，最近的几个研究表明，地中海饮食能帮助哮喘和花粉症儿童减轻症状，但是&对于成人哮喘患者的效果还不清楚&。

Objective: The aim of this study was to estimate the contribution of polymorphisms in the positionally cloned asthma candidate genes ADAM33, PHF11, DPP10, GPRA and PTGDR to the risk of asthma, total and specific immunoglobulin E level, lung function and wheezing in a large, nationally representative, population.

为了评价原位克隆哮喘候补基因ADAM33， PHF11， DPP10， GPRA 和 PTGDR的多态性与哮喘发病危险因素之间的联系，Blakey等人在全国范围内进行了一项大型调查，他们选择了英国白人家族中1958年出生的独生子作为研究人群(n = 7703)，询问其喘息症状，测其总IgE、特异性IgE、肺功能，同时对其某些基因型和单核苷酸多态性进行相关分析。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。