哮喘

Methods: The asthmatic guinea pig model was established with the ovalbumin challenge methods. Forty-eight guinea pigs were randomly divided into six groups: normal control group,asthma model group,DXM treated group,three dose groups of Jianerqiangshen electuary. The effects of relieving asthmatic attacks were observed,and pulmonary morphology and ultramicrostructures were observed too.

采用卵蛋白致敏法制备豚鼠哮喘模型，将豚鼠随机分为6组，即空白对照组、模型组、阳性对照组、中药3个剂量组，分别观察各组引喘潜伏期、支气管和肺组织的病理及超微结构变化。

Bronchial asthma is a disease that it? s behavior is reciprocity emphraxis in bronchial and it? s etiological factor is allergen or non-llergen which exists in or out.

支气管哮喘是由于外在或内在过敏原或非过敏原等因素，致使以支气管发生可逆性阻塞为特点的疾病。

Results: 1 The capacity of engulfment of A549 cells started enhancing at the 1h of preincubation with dexamethasone, reached the highest at the 4h of preincubation,At the 8h、24h of preincubation the capacity of engulfment evidently reduced. 2 Glucocorticoid cytosolic receptors antagonist RU38486 inhibited the improved engulfment ability by dexamethasone. 3Phagocytosing apoptotic eosinophils did not change the release of IL-6 and IL-8,but can inhibited the release of IL-6 and IL-8 from A549 cells stimulated by lipopolysaccharide. 4Increasely uptaking by dexamethasone also did not agitate the release of IL-6 and IL-8 from A549 cells. Conclusion: 1Dexamethasome improve the phagocyte capacity for apoptotic eosinophils of A549 cells by glucocorticoid cytosolic receptors, and the effect presents time-dependently. 2Phagocytosis of apoptotic eosinphils can degrade inflammatory reflection, so it is likely to be critical in the control of asthma inflammation.

结果： 1 A549细胞在地塞米松诱导后1小时吞噬能力开始升高，4小时吞噬能力达最高峰，8小时、24小时吞噬能力明显下降 2加入RU38486后抑制了地塞米松所增强的吞噬能力 3凋亡嗜酸粒细胞的吞噬并不能改变A549细胞释放IL-6和IL-8，但能抑制脂多糖刺激A549细胞后IL-6、IL-8的分泌 4地塞米松增加的吞噬也不激发A549细胞释放IL-6和IL-8 结论： 1地塞米松促进A549细胞吞噬凋亡的嗜酸粒细胞是通过A549细胞糖皮质激素胞浆受体发挥作用的，并且具有时间依赖性 2 A549细胞吞噬凋亡的嗜酸粒细胞能降低炎症反应，对哮喘炎症的控制具有重要意义

EOS is one of the effect cells in asthma.

EOS是参与哮喘病理过程的炎症细胞之一。

Using immunohistochemical and eosin stain, expression of ERK1/2 and Elk in the lung of asthma model was observed.

三、应用免疫组织化学和伊红复染方法，观察了在体哮喘模型肺内ERK1/2和Elk的表达。

Bronchial asthma;cold type asthma; heat type asthma; IgE;SIL -- 2R; T -- lymphocyt subpopulations; Eosinophile lung function;clinical study

支气管哮喘；冷哮证；热哮证；IgE；可溶性白细胞介素Ⅱ受体；T淋巴细胞亚群；嗜酸粒细胞；肺功能；临床研究

Background: Churg-Strauss syndrome is a rare systemic vasculitis associated with asthma, eosinophilia, sinusitis, and pulmonary infiltrates.

背景： Churg-Strauss综合征是一种少见的伴有哮喘，嗜酸性粒细胞增多，鼻窦炎，肺部浸润的全身性血管炎。

In the transgenic murine model of asthma, the overexpression of IL-5 induces eosinophilia in peripheral blood and the airways.

研究证明IL-5在从骨髓动员Eos及诱导Eos生长、分化、增殖、激活中具有重要作用，过量表达IL-5的哮喘模型转基因小鼠可引起血和肺组织Eos浸润及气道炎症。

The objective of the present study was to investigate the kinetics of high doses of inhaled steroid fluticasone in comparison with oral steroid prednisone on plasma protein leakage and bronchial eosinophilia in adults with moderate asthma exacerbations.

研究主旨是对比吸入高剂量氟替卡松和口服强的松在成人中度哮喘发作病例中蛋白渗漏及支气管嗜酸细胞的动态变化。

Although LTE4 shows negligible activity at the type 1 and 2 receptors for cys-LTs (CysLT1R and CysLT2R), it is a powerful inducer of mucosal eosinophilia and airway hyperresponsiveness in humans with asthma.

尽管LTE4对CysLT1R和 CysLT2R的作用很小，但它在哮喘患者中却易导致粘膜内嗜酸性粒细胞增多和气道高反应性。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。