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哮喘

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Objective To observe the effect of Kechuanning on peripheral white blood cells of patients with bronchial asthma.

目的观察咳喘宁对支气管哮喘患者外周血白细胞计数的影响。

Objective To observe the curative effects of bronchial asthma by acupuncture and moxibustion therapy.

目的 观察综合针灸疗法对支气管哮喘的临床效果。

Objective To study the role of CD+4CD45RO+ T lymphocytes in the pathogenesis of bronchial asthma.

目的 探讨记忆性(CD+4CD45RO+)T淋巴细胞在支气管哮喘发病中的作用。

Abstract] Objective:To evaluate the clinical efficacy of Fuketuo on children with bronchial asthma.

摘要] 目的:观察复可托治疗婴幼儿支气管哮喘的临床疗效。

The result showed that there was no expression in the normal control group and an apparent expression of ERK1/2 and Elk in the asthma group. A rather dense expressing of ERK1/2 was at bronchiole and mucous membrane, sub mucous membrane, smooth muscle, cytoplasm and nuclei of the out layer of the smooth muscle cell and an expression of positive fiber at submucous membrane.

结果发现正常肺内没有发现ERK1/2和Elk的表达,而哮喘时肺内有明显的ERK1/2和Elk表达,ERK1/2较密集表达在小支气管和细支气管的粘膜层、粘膜下层、平滑肌层和平滑肌外层细胞的胞浆和胞核中,也可见粘膜下层有阳性纤维表达。

Severe nonspecific airway inflammation is demonstrated in asthmatic patients with sudden death. Lesions of the left ventricle and mucous plug in bronchiole may contribute to the main cause leading sudden death.

结论哮喘猝死患者气道存在明显的非特异性炎症反应,心肌受损和细支气管粘液栓形成为其主要致死原因。

Results There was no apparent gender difference among 14 patients. 9 patients were younger than 30 years old. Pathological examination showed that bronchial infiltration of eosinophils in 14 patient (100%), thickened basement membrane of the bronchial mucosa in 12 patients (85.7%), proliferation of smooth muscle cells in 11 patients (78.6%), proliferative mucous gland in 9 patients (64.3%), mucous plug in bronchiole in 8 patients (57.1%), and cicatvization of left ventricle in 10 patients (71.4%).

结果哮喘猝死患者无性别差异,年龄30岁以下者9例(64.3%);病理改变的特点为支气管管壁嗜酸细胞浸润14例(100%),粘膜基底膜增厚12例(85.7%),支气管平滑肌细胞增生11例(78.6%),粘液腺增生、肥大9例(64.3%),细支气管内粘液栓形成8例(57.1%);左心室壁瘢痕形成10例(71.4%),病变主要位于左心室侧壁和心尖部。

Coli BL21 and purified. The binding activities of immune sera to three EDs were examined with ELISA and Western blotting analysis.②Asthma model was induced with ovalbumin in mice of vaccine group, control vector group and asthma group. Airway pressure-time index and number of cells in BALF were checked. The quantity of goblet cells in bronchiole and the level of MUC5AC mRNA in lung were investigated by PAS staining and RT-PCR assay.

采用ELISA和Western blotting法检测免疫血清抗体对ED的亲合力。2、对DNA疫苗组小鼠制备OVA致敏哮喘模型,检测气道压力峰值—时间指数、支气管/肺泡灌洗液中炎性细胞数量,PAS特染观察小支气管杯状细胞数量及RT-PCR法检测肺组织中粘蛋白MUC5AC mRNA水平,免疫组化和RT-PCR法检测GM-CSF的蛋白与mRNA水平。

The result showed a thick and dense distribution of bronchus and bronchiole of asthma group; a sparse distribution in respiratory bronchiole and pulmonary alveoli; some positive fibers extrude the epithelium mucosae into the alveoli.

结果发现哮喘组肺内支气管及细支气管阳性纤维增粗、分布密集度显著增加;在呼吸性细支气管及肺泡亦偶有分布;有部分阳性纤维经粘膜上皮内伸出并暴露于管腔内。

The authors found that 18% of these children had a bronchiolitis visit and contributed to 31% of asthma diagnoses.

结果:在90,341儿童中,有18%的婴儿有细支气管炎的随访,在这些婴儿中有31%确诊幼童时期的哮喘

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