哌啶

Alkylidene cycloketones such as aza-cycloketones are common features of many bioactive compounds. Few methods reported are effective to construct these motifs in a stereospecific and controllable manner.

芳亚烷基-环酮结构尤其是含有氮原子的3-亚烷基-哌啶-4-酮是生物活性小分子中一种较为常见的结构，对其合成方法的研究报道却很少，已知的方法具有很大的局限性。

Methods 80 cases were divided into control group and test group with 40 cases respectively. Epidural catheter was left in test group, connected with "Tuoren" patient-controlled epidural analgetic pump with dicaine 100 mg+morphine 10～15 mg+droperidol 5 mg,which were dissolved into NS to 100 ml. LCP model was as follows:morphine 2～3 mg, background dosage: 2 ml/h, PCA 0.5 ml each time; The control group injected morphine 3 mg through epidural conduit each time to relieve spasm and pain according to the symptoms to observe and record the effects and side effects. Results Test group:39 cases were with remarkable effect, 1 cases was common.

将80例前列腺术后随机分为试验组与对照组各40例，试验组术毕保留硬膜外导管，接国产&驼人牌&一次性患者自控硬膜外镇痛泵，药液配方为丁卡因100 mg+吗啡10～15 mg+氟哌啶5 mg加入生理盐水至100 ml，LCP模式（负荷量：吗啡2～3 mg，背景量：2 ml/h，PCA 0.5 ml/次）；对照组据疼痛症状经硬膜导管推注吗啡3 mg/次解痉止痛，观察并记录术后解痉镇痛效果及不良反应。

In the presence of ethanol- HCl solution, arylamine-HCl and w=37% aqueous formaldehyde solution or the condensation product of arylamine and formaldehyde are directly reacted with ethyl 3-oxo-2-phenylmethylenebutyrate to form l-aryl-2-phenyl-3-carbethoxy-4-piperidone.

2－苯亚甲基－3－丁酮酸乙酯与芳香胺和w＝37％甲醛水溶液或芳胺和甲醛的缩合物在氯化氢－无水乙醇存在下可直接发生的Mannich反应，得到1－对位取代芳基－2－苯基－3－羰乙氧基－哌啶－4－酮。

The bay area has no substituent and has electron-withdrawing groups,such as bromine atom,cyano-group and 4-formyl phenoxy group compounds have strong absorption in 525 nm,when excitated them,they have strong yellow and salmon pink luminescence bettwen 538 and 566 nm.When introduce electron-donating substituents,such as phenoxy group,morpholinyl,piperidinyl and n-butylamino group,the absorption bathochromic shift while the electron-donating ability is improved,bettwen 536 and 692 nm have strong absorption,reach to the near-infrared region. When excitated them,only the phenoxy group compound has strong salmon pink luminescence in 572 nm,the others have no fluorescence.

其中，港湾位无取代的以及含吸电基团(—Br、—CN、对甲酰基苯氧基)化合物在525 nm左右处均有很强的吸收ε＞10~4M~(-1cm~(-1)，当光激发时，港湾位无取代、溴代和氰基取代物发出538～547 nm的强烈黄色荧光，对甲酰基苯氧基取代物则发出566 nm的强烈橙红色荧光；含供电基团(苯氧基、吗啉基、哌啶基、正丁氨基)化合物随着供电子能力的增强，吸收发生红移，在536～692 nm处均有很强的吸收ε＞10~4M~(-1cm~(-1)，达到了近红外区，当光激发时，只有苯氧基取代物发出572 nm的强烈橙红色荧光，而含氮供电基取代物均发生了荧光淬灭。

Factories strong technical force, advanced production equipment, production of meglumine, Portugal TOA, benzylamine and its family of products, sesame phenol, quetiapine fumarate major intermediate, 4 - hydroxy droperidol, and other products sold at home and abroad.

工厂技术力量雄厚，生产设备先进，生产的葡甲胺、葡辛胺、苄胺及其系列产品、芝麻酚、富马酸喹硫平主要中间体、4-羟基哌啶等产品远销海内外。

Objective To observe and explore the mechanism of effect of Dipsacus asperciaes on the expression of superoxide dismutase and glutathione peroxidase in Alzheimer mice induced with haloperidol.

目的 探讨五鹤续断对氟哌啶醇致痴呆大鼠抗氧化酶表达影响的作用机制。

Except normal group, other groups were peritoneally administrated with Dipsacus asperciaes injection.

除正常对照组外，其余大鼠均用氟哌啶醇建立痴呆病(Alzheimer Disease， AD)动物模型，实脸组同时腹腔注射五鹤续断注射液。

Except control group, other 3 groups were made with aloperidin as models of Alzheimer disease, in which experimental groups were peritoneally administrated with Trillium tschonoskii Maxim and Dipsacus asperciaes injections respectively.

除对照组外，其余大鼠均用氟哌啶醇建立痴呆症(Alzheimer Disease， AD)动物模型，实验组分别腹腔注射延龄草注射液、续断注射液。

The key intermediate 3-methylaminopiperidine was synthesized from 3-methylaminopyridine by two methods,formylation and lithium aluminium hydride reduction or condensation with triethyl orthoformate and sodium borohydride reduction,and then hydr...

以3-氨基吡啶为原料，分别通过甲酰化反应、氢化铝锂还原和原甲酸三乙酯缩合、硼氢化钠还原两种方法得到3-甲胺基吡啶，最后经催化氢化得到中间体3-甲胺基哌啶。

The key intermediate 3- methylaminopiperidine was synthesized from 3-methylaminopyridine by two methods, formylation and lithium aluminium hydride reduction or condensation with triethyl orthoformate and sodium borohydride reduction, and then hydrolysis.

以3-氨基吡啶为原料，分别通过甲酰化反应、氢化铝锂还原和原甲酸三乙酯缩合、硼氢化钠还原两种方法得到3-甲胺基吡啶，最后经催化氢化得到中间体3-甲胺基哌啶。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。