咪唑基

Ionic liquids of 1-carboxymethyl-3-ethylimidazolium chloride, 1-methoxyethyl- 3-ethylimidazolium chloride ([C2OC1-EIM]Cl) and 1-[2-(2-chloroethoxy)ethyl]-3-ethylimidazolium chloride ([Cl-C2OC2-EIM]Cl) were synthesized, and their chemical structures were confirmed by FT-IR and 1H NMR.

合成了三种含有羧基或醚基的离子液体， 1-羧甲基-3-乙基咪唑氯化物、1-甲氧乙基-3-乙基咪唑氯化物([C2OC1-EIM]Cl)和1-[2-(2-氯乙氧基)乙基]-3-乙基咪唑氯化物([Cl-C2OC2-EIM]Cl)，用FT-IR和1H NMR对它们的化学结构进行了表征。

The results showed that the decomposition of 4-nitroimidazole began with the split of the C—NO2 bond in the temperature range of 185—210℃. The strongly oxidative product NO2 destroyed the instable annulus of 4-nitroimidazole instantly, all the other C＝N, C＝C, C—H and N—H bonds of the five membered ring were broken simultaneously, and the detected gas products of 4-nitroimidazole decomposition were NO2, CO2 and CO.

结果表明，4-硝基咪唑的催化热分解起始于其分子中C-NO2化学键的断裂，温度范围是185~210℃。C-NO2键的强氧化性的裂解产物NO2瞬间作用于4-硝基咪唑分子中不稳定的五员环，使化学键C=N、C=C、C-H和N-H同时被打破。4-硝基咪唑的气体分解产物包括NO2、CO2和CO。

Goal compound synthesis namely: Take the vanillic acid as outset raw material, obtains 4- hydroxyl - 3- anisole methyl formate with the methyl alcohol reflux conditions, then after the etherification, the nitration, the return to original state, the ring closure response obtains 6- methoxy - 7- animal pen oxygen radical kui zuo lin - 4- alkone, then passes through the chlorination, the substitution aniline, to escape responses again and so on animal pen oxygen radical, etherification to obtain the goal compound; The goal compound and the diethylamine had the amine substitution reaction to obtain TM1, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(N, N- two ethyl aminos) third oxygen radical] kui zuo lin; Through zuo has the etherification with the Austria niter to respond obtains TM2, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(2- methyl - 5- nitryl imidazole) third oxygen radical] kui zuo lin.

目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

Synthesis of target compounds namely: to vanillic acid as the starting material with methanol under reflux conditions for 4 - hydroxy -3 - p-methyl, then ether, and nitration, reduction, cyclization reaction 6 - methoxy -7 - benzyloxy-quinazoline -4 - one, and then by the chloride in place of aniline, benzyloxy-off, such as etherification reaction of the target compounds; target compounds with the second and third occurrence of substitution reactions of amines by the TM1, that is, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(N, N-diethyl amino) oxy c] quinazoline; with ether occurred Ornidazole reaction of TM2, namely, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(2 - methyl -5 - nitroimidazole) C oxy] quinazoline.

本论文以嘌呤类似物喹唑啉为母核，分别在其4位和7位引入结构多样的取代苯氨基和柔性侧链，设计了一系列4-取代苯胺基-6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉类化合物。目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

The reactivities of 1 and other long chain oximes with p nitrophenyl diphenyl phosphate, p nitrophenyl diethyl thiophosphate, and O ethyl ( s β diisopropylaminoethyl) methyl phosphonothiolate were studied.

报道了一种新的高亲核长链咪唑肟N 十四烷基咪唑 2 甲醛肟的设计与合成，并比较了它及其他长链咪唑肟与有机磷酸酯二苯基、对硝基苯基磷酸酯、对硫磷及 Vx 的反应活性。

To explore new synthetic methods, we set out a careful investigation of the reaction of benzimidazolium salt with many nucleophilic agents, including the active aromatic compounds and heteratom nucleophilic agents, and found that the quaternary C=N is not so active; when benzimidazolium salt is reacted with big nitrogen nucleophilic agent? phthalimide, it does not give the expected addition product, instead, produces N-alkyl phthalimide through alkyl-transfermation from benzimidazolium salt to phthalimide.

为了开发新的合成方法，研究了苯并咪唑盐与各种亲核试剂（活泼芳环与杂原子亲核试剂）的反应，发现苯并咪唑盐不与活泼芳环及杂原子亲核试剂发生2位加成反应；在与体积较大的位阻型N亲核试剂邻苯二甲酚亚胺反应时，未得到亲核试剂与极化的C＝N的加成产物，而是得到N烷基化的邻苯二甲酰亚胺，进一步研究表明，苯并咪唑盐将1（3）位N上的烷基转移给了邻苯二甲酰亚胺，并讨论了其反应机理和取代基，溶剂效应。

Simultaneously we prepared benzimidazolines with two methods by the of reduction benzimidazolium salts with NaBH_4 and Grignard addition with benzimidazolium salts. Thus we provided a new biomimic synthetic method for 13 kind of tetrahydroisoquinoline starting from carboxylic aicd and halid, gave a new idea of the synthesis for new drugs.It can make many kind ofβ-carboline alkaloids which have bioactivity to antibacterium, antivirus and antitumor to start from 1,2,3,4-tetrahydro -β-carboline.

本文以1，3-二甲基苯并咪唑碘盐和2-取代的1，3-二甲基苯并咪唑碘盐为原料，采用了NaBH_4还原和Grignard试剂加成两种方法，制备了13种1，3-二甲基苯并咪唑烷和2-取代的1，3-二甲基苯并咪唑烷作为四氢叶酸辅酶一碳单元转移新模型，在酸性条件下，以2-(3，4-二甲氧基苯基)乙胺作为接收一碳转移的亲核试剂，完成了13种重要的四氢异喹啉类化合物的新合成方法研究。

N-heterocyclic compounds, such as indole, imidazole, 2-methylimidazole, 2-ethylimidazole, pyrrole and pyrrolidine, could be effectively N-methylated with DMC in the presence of 1-n-butyl-3-methylimidazolium chlorid.

吲哚、咪唑、2-甲基咪唑、2-乙基咪唑、吡咯和四氢吡咯等含氮杂环化合物在氯化1-正丁基-3-甲基咪唑的催化下能被DMC有效地N-甲基化。

A high insensitive explosive compound , 2,4-dinitroimidazole (2,4-DNI) synthesized by nitrating 2-nitroimidazole and thermal rearrangement of 1,4-dinitroimidazole, is reviewed.

综述了高能不敏感单质炸药———2，4-二硝基咪唑的两种合成方法：2-硝基咪唑硝化法、1，4-二硝基咪唑(1，4-DNI)的热重排法

Synthesis and structural characterization of novel cycioplatinated complexes with 2-aryl imidazolines 2-arylimidazoline ligands 2a-2d were synthesized from benzoyl chloride or p-methoxybenzoyl chloride with aminoethanol or valinol and 2e was synthesized from 2-phenylimidazoline.

新型2-芳基咪唑啉环铂化合物的合成与结构表征以苯甲酰氯或4-甲氧基苯甲酰氯和氨基醇(2-氨基乙醇或外消旋的缬氨基醇)为原料，合成了四种2-芳基咪唑啉配体2a-2d，以2-苯基咪唑啉为原料合成了配体2e，其中2d为新化合物。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了