咪唑

Goal compound synthesis namely: Take the vanillic acid as outset raw material, obtains 4- hydroxyl - 3- anisole methyl formate with the methyl alcohol reflux conditions, then after the etherification, the nitration, the return to original state, the ring closure response obtains 6- methoxy - 7- animal pen oxygen radical kui zuo lin - 4- alkone, then passes through the chlorination, the substitution aniline, to escape responses again and so on animal pen oxygen radical, etherification to obtain the goal compound; The goal compound and the diethylamine had the amine substitution reaction to obtain TM1, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(N, N- two ethyl aminos) third oxygen radical] kui zuo lin; Through zuo has the etherification with the Austria niter to respond obtains TM2, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(2- methyl - 5- nitryl imidazole) third oxygen radical] kui zuo lin.

目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

Three classes, forty-eight in total, of pyrazole compounds, imidazolo[1,2-b] pyrazoles, dipyrazolylmethanones and pyrazolyloxadiazoles, have been synthesized, and they have been fully characterized by modern spectroscopic methods, two of which were further confirmed by X-ray diffraction. Most of these compounds have been evaluated for the inhibitions of Gram-positive bacterium represented by Staphylococcus aureus and Gram-negative bacterium represented by Klebsiella pneumoniae.

论文合成了咪唑并[1，2-b]吡唑类、二吡唑基甲酮类和吡唑连噁二唑类共三类48个化合物，使用了现代结构测试手段对所合成的化合物进行了结构表征，其中两个化合物经过了X-Ray射线衍射分析，并对其中大部分化合物进行了以金黄色葡萄球菌和肺炎克雷白杆菌为代表的革兰氏阳性菌和革兰氏阴性菌的初步抑菌活性测试。

Firstly the mid-pruduct imidazoline was produced by reaction of naphthenic acid and diethylene triamine, then the corrosion inhibitor amphoteric imidazoline, which is soluble in water, was produced by reaction of imidazoline and sodium monochloroacetate in aqueous solution.

以高纯环烷酸与二乙烯三胺反应合成了中间体咪唑啉，再以去离子水为溶剂，用氯乙酸钠对该中间体进行两性化，制得了水溶性两性咪唑啉缓蚀剂。

Bisbenzimidazolium salts were used as a tetrahydrofolate coenzyme model, and thus the biomimetic synthesis of twenty-four acyclic diketones as precursors for macrocyclic ketones was successfully accomplished by using the addition-hydrolysis reaction of the bisbenzimidazolium salts with alkyl magnesium halide, wherein six diketones have not been reported in literature.

在本文中，受四氢叶酸辅酶的一碳单元转移反应的启发，作者以双苯并咪唑盐作为四氢叶酸辅酶模型，利用格利雅试剂与双苯并咪唑盐的加成-水解反应，成功合成了二十四种作为麝香酮及类似大环酮重要前体的长链二酮，同时，提供了一种麝香酮及类似大环酮的仿生合成新方法。

This thesis includes two parts. The first part is study on hydroformylation of alkenes in ionic liquid-H2O system.

本论文分两部分：咪唑离子液体—水体系中的烯烃氢甲酰化反应研究和新型咪唑类手性季铵盐的合成。

The conductivity and the molar conductivity of the ionic liquid in actone, water, DMF, acetic acid were investigated at different temperatures.

利用磷酸三丁酯与N-甲基咪唑在恒温150℃下一步合成了离子液体1-丁基－3-甲基咪唑磷酸二丁酯，考察了其在丙酮，水，DMF，乙酸溶剂中的电导率及摩尔电导率。

The inhibition efficiency and the application on synergizes strengthening the inhibitive efficiency during the functions and applications of the preparation of its are emphasized,its inhibition mechanism are summarized.

文章介绍了咪唑啉衍生物缓蚀剂合成的几种常见方法及影响其产率的因素，重点强调了其缓蚀性能和复配增效技术在制备咪唑啉衍生物缓蚀剂中的应用，概述了缓蚀机理，并提出了发展趋势。

Methods Loading dose 5mg of midazolam was given by slow intravenous injection first.Ⅱ-Ⅲ level Ramsay calm gradings was obtained by continuous giving maintenance does 0.04~0.2 mgkg^(-1)h^(-1) with transfer pump. Simultaneously continuous monitoring was given to patient's SpO2 and CVP. Artery courage vigor and Ramsay grading were analyzed before the medication was applied and two hours after the medication.

选择我科2007年6月～2008年5月住院患者中需机械通气的病例23例，首先缓慢静注咪唑安定5 mg的负荷量，然后持续静脉泵注维持量的咪唑安定0.04~0.2 mgkg^(-1)h^(-1)，以获得Ⅱ~Ⅲ级Ramsay镇静评分，同时连续监测患者的SpO2、CVP及用药前和用药2 h后动脉血气及Ramsay镇静分级。

The treatment disease infected by deep fungi such as Candidiasis, Cryptococcosis, etc, develop from Nystatinum, Amphotericin B, Criseofulvinum to Ketoconzole, Capculat, Traconazoli, Fluconazoli, woliconzoli, which are efficient,low poisonous,high selective new fungistat.

深部真菌感染的各种疾病，如念珠菌病、霉菌病、隐球菌病等的治疗，由制霉菌素、灰黄霉素、两性霉素B ，发展到用咪唑类药物，如酮康唑、伊曲康唑、氟康唑、沃利康唑等高效、低毒、选择性好的新型抗真菌药。

There was significant difference(P.05)between the post-established and the pre-established in the number of ulcerations. Compared with the post-established,CD4+ T-lymphocyte and CD4+/CD8+ in pre-established were improved(P.05). There was no difference between Levamisole and Shenqi Fuzheng Injection.

实验大鼠给药后，参芪扶正注射液组、左旋咪唑组外周血CD4+、CD4+/CD8+均有回升，较对照组有显著性差异（P.05），参芪扶正注射液组与左旋咪唑组相比，差异无统计学意义。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。