咪唑

Fungicides washed with alkaline solution, the choice of the following drugs:① clotrimazole suppository or tablet, 1 time per night, each one or one, deep into the vagina, once a 7;② Saindak Nanjing suppository every night into a vagina, once a 7;③ nystatin suppository or tablet, 1 time per night, each one or 1 (100,000 U ), once a 7 on the 10th;④ meters may be set vagina effervescent tablets, one night, into the vagina, once a 5;⑤ 1% aqueous gentian violet涂擦vagina, 3 to 4 times a week, for 2 weeks, the drug cost, the effect is also very good, but must pay attention to drug concentration, if the drug or administering a drug过浓too frequent and easy to cause chemical vulvitis and epidermal rupture due to drug easily contaminated clothing, now has more clinical less use.

杀菌剂以碱性溶液冲洗后，选用下列药物：①克霉唑栓剂或片剂，每晚1次，每次1粒或1片，塞入阴道深部，连用7日；②达克宁（硝酸咪康唑miconazole）栓剂，每晚1粒塞入阴道，连用7日；③制霉菌素栓剂或片剂，每晚1次，每次1粒或1片（10万U），连用7～10日；④米可定阴道泡腾片，每晚1片，塞入阴道内，连用5日；⑤1％龙胆紫水溶液涂擦阴道，每周3～4次，连续2周，药物价廉，效果也很好，但必须注意用药浓度，若药物过浓或用药过频，易引起化学性外阴炎和表皮破溃，因药物易污染衣物，现临床已较少使用。

We designed this prospective, randomized, double-blind, controlledtrial to evaluate whether intranasal dexmedetomidine is as effectiveas oral midazolam for premedication in children.

我们设计了这个前瞻性、随机、双盲、对照的试验来评估右美托咪啶经鼻给药在小儿术前用药中应用是否和口服咪达唑仑一样有效。

Methods Seven probe drugs were incubated with or without methyl protodioscin respectively in human microsomes. The specific substrates used in this study were caffeine (CYP1A2), dextromethorphan (CYP2D6), tolbutamide (CYP2C9),-mephenytoin (CYP2C19), chlorzoxazone (CYP2E1), coumarin (CYP2A6) and midazolam (CYP3A4). The concentrations of the substrate metabolites (paraxanthine, dextrorphan, 4-hydroxytolbutamide, 4-hydroxymephenytoin, 6-hydroxychlor-zoxazone, 7-hydroxycoumarin and 1-hydroxymidazolam) were determined by HPLC and LC-MS/MS. Results MPD 1-10 μmolL^(-1 had no significant inhibition on the activities of the seven cytochrome P450 enzymes.

将MPD和CYP450酶7种亚型的特异性探针底物咖啡因(CYP1A2)、右美沙芬(CYP2D6)、甲苯磺丁脲(CYP2C9)、s-美芬妥因(CYP2C19)、氯唑沙宗(CYP2E1)、香豆素(CYP2A6)及咪达唑仑(CYP3A4)与人肝微粒体进行孵化反应，采用HPLC和LC-MS/MS法测定对应的7种代谢产物（1，7-二甲基黄嘌呤、去甲右美沙芬、4-羟基甲苯磺丁脲、4-羟基美芬妥因、6-羟基氯唑沙宗、7-羟基香豆素和1-羟基咪达唑仑）的浓度，通过与对照组比较，确定MPD对以上7种酶活性的影响。

The rates of resistance of Candida albicans to miconazole and fluconazole were 55.1% and 41.6%, respectively.

白念珠菌对咪康唑和氟康唑的耐药率已分别达55.1%及41.6%。

Methods The minimal inhibitory concentrations of 134 clincal isolates of bacteria were determined by standard agar dilution method,and miconazole nitrate cremor.

采用琼脂平皿稀释法测定2%硝酸舍他康唑软膏对134株临床分离分离致病菌的最低抑菌浓度，并与硝酸咪康唑霜进行比较。

Objective To evaluate the in vitro antifuangal activity of 2% sertaconazole nitrate ointment and miconazole nitrate cremor. Methods The minimal inhibitory concentrations of 134 clincal isolates of bacteria were determined by standard agar dilution method,and miconazole nitrate cremor.

目的 评价硝酸舍他康唑软膏的体外抗菌活性方法采用琼脂平皿稀释法测定2%硝酸舍他康唑软膏对134株临床分离分离致病菌的最低抑菌浓度，并与硝酸咪康唑霜进行比较。

IV midazolam 0.015 mg/kg administered 90 s before induction of anesthesia with etomidate is effective in reducing myoclonic movements and does not prolong recovery in unpremedicated patients after short procedures.

用依托咪酯进行诱导前90秒静脉注射0.015 mg/kg 咪达唑仑对降低肌振挛的发生是很有效的，并且在一个短暂的过程后这并不延迟未使用术前用药的病人的苏醒。

Objective:This study is investigate the different dosage midazolam on the sedation、inhibit stress reaction、anterograde amnesia before epidural anesthesia.

目的：本研究的目的是比较硬膜外麻醉前给予不同剂量的咪达唑仑对患者镇静、顺行性遗忘和应激作用的影响，探讨咪达唑仑术前应用的适宜剂量，以利于病人的术中心理保护和术后康复。

RESULTS: Ketamine, etomidate, and midazolam each attenuated acetylcholine contraction dose-dependently, whereas thiopental had no effect.

结果：氯胺酮、依托咪酯和咪达唑仑都呈剂量依赖的减弱乙酰胆碱的收缩，然而硫喷妥钠没有影响。

Sensitivity results to ten antifungals showed that the frequent fungi were sensitive to amphotericin b, nystatin, econazaole, miconazole, clotrimazole, ketoconazole, flucytosine, itraconazole, fluconazole and griseofulvin.

常见真菌对常见抗真菌药物的敏感性由高到底依次为两性霉素b、制霉菌素、益康唑、克霉唑、酮康唑、咪康唑、5-氟胞嘧啶、伊曲康唑、氟康唑、灰黄霉素。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。