咪唑

objective to optimize the formulation of methimazole loaded polylactic co glycolic acid microspheres.

目的 优化甲巯咪唑聚乳酸羟基乙酸共聚物微球的处方工艺。

Water, Sodium Laureth Sulfate, Cocamidopropyl Betaine, Cocamide MEA, Disodium Cocamphodiacetate, Sodium Lauryl Sulfate, PEG 40 Hydrogenated Castor Oil, Perfume, Sodium Chloride, Propylene Glycol, Quaternium 80, Methylparaben, Polyquaternium 10, Hydroxypropyl Guar Hydroxpropyltrimonium Chloride, Citric Acid, Diazolidinyl Urea, Tetrasodium EDTA, Polyquaternium 7, Propylparaben, Sodium Hydroxide, Panthenol, Persea Gratissima Oil, Penta Sodium Pentetate, Hedera Helix Extract, Bambusa Vulgaris Extract

水，月桂醇聚醚硫酸酯钠，椰油酰胺丙基甜菜碱，椰油酰胺MEA，椰油酰两性基二乙酸二钠，月桂醇硫酸酯钠，PEG 40 氢化篦麻油，香料，氯化钠，丙二醇，季铵盐-80，苯甲酸甲脂，聚季铵盐-10，羟丙基瓜尔胶羟丙基三甲基氯化铵，柠檬酸，重氮烷基咪唑脲，乙二氨四醋酸四钠，聚季铵盐-7，对羟基苯甲酸丙酯，氢氧化钠，泛酰醇，酪梨油，喷替酸五钠，常春藤萃取物，银竹萃取物。

In Chapter 3, six mixed-valence or heteronuclear metal imidazolates have been synthesized and structurally characterized through introducing univalent metal ion into bivalent metal imidazolates, which give a rich topological chemistry including novel topological networks.

其中尤为突出的是混价铜咪唑配合物的控制合成，通过精确调节反应条件得到了混价比例不同的产物，其中一种呈现出新型的四连接网络的拓扑类型。

Both catalytic activity and selectivity of Ru(PPh_3)_3Cl_2 were improved in ionic liquid BMImPF_6/DME medium.The conversion of hexene and selectivity ofβ-adduct for the hydrosilylation reaction of 1-hexene with triethoxysilane catalyzed by Ru(PPh_3)_3Cl_2 in ionic liquid BMImPF_6DME (V/V=1/4) medium at 90℃were 100% and 89.0%,respectively.

实验结果表明，在乙二醇二甲醚/离子液体1-丁基-3-甲基咪唑六氟磷酸盐(BMImBF_6)(V/V =1/4)介质中，于90℃下，己烯与三乙氧基硅烷反应的转化率为100%，β加成物的选择性可达89.0%，而用Rh(PPh_3)_3Cl作为反应的催化剂，在纯离子液体BMImPF_6中，就可以高效催化烯烃与三乙氧基氢硅烷的加成反应，过渡金属Rh(PPh_3)_3Cl，Ru(PPh_3)_3Cl_2催化剂/离子液体BMImPF_6催化体系，不仅解决了产物与催化剂分离困难这一难题，同时，离子液体BMImPF_6的存在提高了过渡金属Rh(PPh_3)_3Cl，Ru(PPh_3)_3Cl_2催化硅氢加成反应的活性，特别是β加成物的选择性。

The polar hydrophilous amino acid Thr is replaced by an unpolar hydrophobous amino acid Ile, a hydrogen bond changed in the higher structure and the point is far away from the active center, so it doesn't influence the activity and thermostability a lot.

亲水的Thr108突变成非极性的Met，导致与该位点空间相邻的N116亲水氨基酸His的极性残基——咪唑环产生空间电位排斥，从而造成His所在的β折叠构象发生改变。

A lot of experiment data show hydrophilic imidazolium-based ionic liquids Br have good EDS performance and the hydroscopicity has little effect on EDS.

从大量数据说明亲水性咪唑类离子液体Br具有较好的脱硫效果，且在较长的时间里其吸湿性对脱硫影响不大，故在工业上有较好的应用前景。

In addition, IT injection of the -2 adrenoceptor antagonist, idazoxan (40 g/rat) 10 minbefore clonidine injection completely reversed clonidine'santi hyperalgesic and anti allodynic effects, as well as clonidine'ssuppressive effect on CCI-induced NR1 phosphorylation in thespinal cord dorsal horn.

另外，可乐定可以抑制 CCI 导致的脊髓背侧角 NR1磷酸化，但是在注射可乐定之前10min ，鞘内注射α－2受体拮抗剂咪唑克生(40 g/小鼠)，可以完全逆转其对抗痛觉过敏的效果。

Methods:The EAE in Lewis rats was induced by giving hypodermal injections in feet with spinal cords homogenate of guinea pigs; The histological changes were observed under light microscope, then changes of incidence rate、latency、clinical symptoms and histology of EAE which were effected by idazoxan with different doses were compared by method of quantization.

采用豚鼠全脊髓匀浆脚垫皮下注射，免疫Lewis大鼠复制EAE模型，采用量化评分法，比较不同剂量组咪唑克生对EAE发病率、潜伏期、临床症状和组织学的影响。

Using Gassian98 with LANL2DZ basis sets, the quantum chemistry calculation of the model was performed.4. A series of ligands which all include imidazolyl group were designed and synthesized. The crystal structure of one of them was determined by X-ray diffraction.

设计并合成了一系列含有咪唑基的配体，应用X-射线衍射方法测定了其中一种配体的晶体结构，并用Gaussian98程序包进行了量子化学计算。

We studied reactions of sulphoxide with aliphatic and aromatic 1,3-dicarbonyl compounds promoted by Cu2·H2O, 2,2′-biimidazole and iodobenzene diacetate, with the presence of K2CO3 as a base and DMSO a solvent.

我们以K2CO3作为碱，DMSO作为反应的溶剂，在二醋酸碘苯、Cu2·H2O、2，2′-联咪唑体系中，对脂肪族和芳香族的1，3-二羰基化合物和亚砜的反应进行了研究。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。