咔啉

Benzimidazoline as a new tetrahydrofolate coenzyme model to perpare alkali can bring a byproduct N, N\'-dimethylaniline, this byproduct can be recycled to produce benzimidazoline as raw materials.

这种新的仿生合成方法，以羧酸和卤代物为起始原料制备四氢-β-咔啉类化合物，可为工业生产β-咔啉类生物碱提供更为方便的条件。

We provided biomimetic synthetic methods for tetrahydro-β-carboline by using the benzimidazoline as a new tetrahydrofolate coenzyme model with tryptamine as nucleophile reagents under the condition of acid.

由四氢-β-咔啉类化合物，可制得多种具有较好抗病毒、抗菌和抗肿瘤活性的β-咔啉类生物碱，因而四氢-β-咔啉类化合物的合成受到人们的广泛关注。

Simultaneously we prepared benzimidazolines with two methods by the reducton of benzimidazolium salts with NaBH_4 and Grignard addition with benzimidazolium salts. Thus we provided a new biomimic synthetic method for 9 kind of tetrahydro-β-carboline starting from carboxylic aicd and halid. A convenient synthetic method for preparing tetrahydro-β-carboline was provided.

本文以1，3-二甲基苯并咪唑碘盐和2-取代的1，3-二甲基苯并咪唑碘盐为原料，采用了NaBH_4还原和Grignard试剂加成两种方法，制备了9种1，3-二甲基苯并咪唑烷和2-取代的1，3-二甲基苯并咪唑烷作为四氢叶酸辅酶一碳单元转移新模型，在酸性条件下，以色胺作为接受一碳转移的亲核试剂，完成9种四氢-β-咔啉类化合物的新合成方法研究。

Tetrahydrofolatecoenzyme,Benzimidazoline,One-carbontransfer,Mannichalkali,Tetrahydroisoquinoline,Tetrahydro-β-carboline

四氢叶酸辅酶，苯并咪唑烷，一碳转移，Mannich碱，四氢异喹啉，四氢-β-咔啉

Compounds of harmane,β-carboline and anatalline were not reported in domestic literatures.

新鉴定的化合物哈尔满、β-咔啉和新烟草灵在国内的文献中尚未见报道。

It contains a 2,5-transtetrahydrofuranyl group on the 1-position of β-carboline.

它是一个在β-咔布啉1-位连有一个2，5-取代的四氢呋喃环的内盐。

A simple method was developed for the analysis of 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-β-carboline (6-OH-MTHβC), 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) in rat brain by high performance liquid chromatography with electrochemical detection.

建立了大鼠脑组织中6-羟基－1-甲基－1，2，3，4-四氢－β-咔啉(6-OH-MTHβC)、5-羟色胺(5-HT)和5-羟吲哚乙酸(5-HIAA)含量的高效液相色谱-库仑阵列电化学检测方法。

Results: Acquired three trifluoromethyl carboline derivatives that the third place having been substituted, the stucture of production is confinned by GC/MS,IR and 'HNMR.

结果：得到三个三位取代的含三氟甲基β-咔啉类化合物，产物结构经红外光谱、核磁共振光谱，质谱确证。

They were two new compounds, [cyclo(Pro-Val-Phe-Phe-Pro-Val-Phe-Ser-Leu),7],[2-N-(1-methoxycarbonylethyl)guanosine, 10], and eight known compounds,(p-hydroxybenzoic acid, 1),(methyl succinate, 2),(russulaceramide, 3),(phenylalanine, 4),(guanine, 5),(β-carboline, 6),(uridine, 8), and (adenosine, 9). All the compounds were isolated from Amanita exitialis for the first time.

分别为：对羟基苯甲酸(p-hydroxybenzoic acid，1)、丁二酸二甲酯(methyl succinate，2)、神经酰胺(russulaceramide，3)、苯丙氨酸（phenylalanine，4）、鸟嘌呤核苷(guanine，5)、β-咔啉(β-carboline，6)、环（脯氨酸-缬氨酸-苯丙氨酸-苯丙氨酸-脯氨酸-缬氨酸-苯丙氨酸-丝氨酸-亮氨酸） [cyclo(Pro-Val-Phe-Phe-Pro-Val-Phe-Ser-Leu)，7]、尿嘧啶核苷(uridine，8)、腺嘌呤核苷(adenosine，9)、2-N-(1-甲氧羰基乙基)鸟苷[2-N-(1-Methoxycarbonylethyl)guanosine， 10]。10个化合物均为首次从致命鹅膏中分离得到，其中化合物7和10为新化合物。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。