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The blood pressure of.1 of pathology physiology mechanism that SAS causes CVD breathes time-out to be able to bring about airframe in elevatory Morpheus anoxic, sympathetic is excessive and excited, element of serous catechu phenolic amine, kidney and hemal endodermis element are elevatory, bring about hemal easy of hemal convulsion; to shrink the function is disorder, can make blood-vessel flowing flesh happening reframes and fleshy, systemic blood-vessel obstruction adds element of the kidney when; is chronic and anoxic, system of hemal and nervous element is activationed, bring about blood pressure to lift. Obstruction of way of energy of life of patient of OSAS of disease of blood of 1.2 low oxygen increases, cause air current to interrupt, breath pauses, at the same time airframe gets used to low oxygen environment gradually, breathing centre drops to low oxygen and sensitivity of disease of blood of tall carbonic acid, breath suspends a frequency increasing, farther aggravating airframe is anoxic. 1.3 heads are self-adjusting the function drops normal person changes quickly in systematic circulation blood pressure when, the head can be passed adjust independently functional generation protects effect, make change of cerebral blood flow not big.

SAS诱发CVD的病理生理机制。1血压升高睡眠中呼吸暂停可导致机体缺氧,交感神经过度兴奋,血浆儿茶酚胺、肾素以及血管内皮素升高,导致血管痉挛;血管舒缩功能紊乱,可使血管平滑肌发生重构和肥厚,全身血管阻力增加;慢性缺氧时肾素—血管紧张素系统被激活,导致血压升高。1.2低氧血症OSAS患者气道阻力增加,造成气流中断、呼吸暂停,同时机体逐渐适应低氧环境,呼吸中枢对低氧和高碳酸血症敏感性下降,呼吸暂停次数增加,进一步加重机体缺氧。1.3脑自动调节功能下降正常人在体循环血压快速变化时,脑可通过自主调节功能产生保护效应,使脑血流量变化不大。

Objectives: We attempt to determine if obstructive sleep apnea leads to higher incidence of positive microvolt T-wave alternan; thus higher risk for arrhythmic death; and correlate MTWA result with severity of OSA as measured by apnea hypopnea index.

目的:我们研究阻塞性睡眠呼吸暂停综合症是否导致阳性微伏级T波电交替发生率增加从而使得致死性心律失常发生的风险增加;由呼吸暂停低通气指数确定的严重睡眠呼吸暂停综合征是否与微伏级T波电交替相关。

Respiratory system impedance was measured continuously over a 90-s apneic period innave and rabbits sensitized to allergens by ovalbumin.

在没有处理过的家兔和已经对卵清蛋白的变应原致敏家兔,连续测定呼吸暂停的90s 内的呼吸系统的气道阻抗。

Sleep Apnea Syndrome is associated with cardiovascular autonomic nervous abnormalities. Hypertensive subjects are characterized by lower HRV than controls at rest. Sympathetic activity increased during nocturnal apneic episodes, which may mediate the cardiovascular complications of sleep apnea.

本研究显示,在SAS患者中心律失常尤其是缓慢型心律失常的发生率增高,并与夜间低氧血症和呼吸暂停的严重性有关,这就提醒我们在对心律失常的诊断和治疗过程中,也应该考虑到SAS的存在。

Objective: To observe the change of measurement values of impulse oscillometry in obstructive sleep apnea and hypopnea syndrome patients and its clinical significance under high altitude condition.

阻塞性睡眠呼吸暂停低通气综合征是一种具有潜在危险性的常见疾病,主要症状为反复发作呼吸暂停、严重打鼾、记忆力损害及高血压等。

CPAP patients were diided post hoc into those whose apnea-hypopnea index was or was not reduced below 15 at this time (CPAP-CSA suppressed, n=57, and CPAP-CSA unsuppressed, n=43, respectiely).

CPAP组患者被分成两组,在这段研究期间,一组的平均呼吸暂停-低通气指数到每小时睡眠15次事件以下,另一组则平均呼吸暂停-低通气指数到每小时睡眠15次事件以上 CPAP-CSA 治疗组,n=57例,未作CPAP-CSA 治疗组, n=43例

The study is the largest to date that looks at how children with varying severities of obstructive sleep apnea fare before and after they have surgery, using both preoperative and postoperative sleep studies.

这项研究是世界上最大的以日期看来,在儿童如何与不同的严重阻塞性睡眠呼吸暂停的票价之前和之后,他们有手术,不管是使用术前,术后睡眠的研究。

"Although we expected marked improements in the apnea-plus-hypopnea index primarily in patients with hypopneas rather than obstructie apneas, lowered the index in all subjects,"

&尽管我们期望在呼吸减弱非阻塞性呼吸暂停患者中能显著改善呼吸暂停低通气指数,而此项治疗可降低所有受试者的这项指数。&

Sleep apnea, also referred to as sleep apnoea, is a common sleep disorder.

睡眠呼吸暂停,也被称为睡眠呼吸暂停,是一种常见的睡眠障碍。

Results: The age of onset, the proportion of smoke, the proportion of cough, expectoration, polypnea, cyanosis, rhonchi and moist rale in two lungs were higher in OS patients than OSAS group, the level of body mass index, neck circumference, the proportion of polypnea, nighttime snore, nighttime apnea, daytime hypersomnolence were higher in OS patients than COPD group, the proportion of heart、pulmonary、kidney、 encephalopathy were higher in OS patients than OSAS group and COPD group, FVC, FEV1, FEV1/FVC, MVV, PaO2, SaO2 were lower in OS patients than OSAS group, FRC, PaCO2 were higher in OS patients than OSAS group, AHI was inversely related to the FEV1, FVC, MVV in Group OS, LSaO2 in Group OS was inversely related to the AHI.

结果:OS组的发病年龄、吸烟者比例、咳嗽咳痰、气促、紫绀、肺罗音比例均高于OSAS组,BMI、NC、夜间打鼾、夜间呼吸暂停、白天嗜睡的比例均高于COPD组;OS组合并心、肺、肾、脑等疾病的比例均高于OSAS组及COPD组;OS组的FVC、FEV1、FEV1/FVC、MVV、PaO2、SaO2的值均低于OSAS组,FRC、PaCO2均高于OSAS组;OS组AHI与FEV1、FVC、MVV呈负相关,LSaO2与AHI呈负相关,LSaO2与FEV1、FVC、MVV呈正相关;OS组的最长呼吸暂停时间、S1+2、NREM均高于OSAS组,而LSaO2、REM均低于OSAS组,AHI、最长呼吸暂停时间、S1+2均高于COPD组,LSaO2、S3+4均低于COPD组。

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