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Homogeneous or heterogeneous base material is selected; an alternately superimposed barrier layer and an alternately superimposed recessed layer are grown and formed at the extension of the base material; donor impurity and acceptor impurity are doped in the interface between the barrier layer and the recessed layer and in the interface between the recessed layer and the barrier layer, and the p type group III nitride material doped at a position selecting superlattice is obtained.

选择同质或者异质的基质材料;在基质材料上外延生长形成变换叠加的垒层和阱层,在垒层与阱层的界面和阱层与垒层的界面掺入施主杂质和受主杂质,得选择超晶格位置掺杂的p型III族氮化物材料,其中,每个生长周期的步骤为:生长带隙较宽的垒层,同时掺入受主杂质;生长施主杂质或受主杂质δ掺杂层;生长非掺的带隙较窄的阱层;生长受主杂质或施主杂质δ掺杂层;在N 2 气氛下对所得的选择超晶格位置掺杂的p型III族氮化物材料退火,即得目标产物。

To get more information of the function of human Era on cell cycle, the complete control inducible mammalian expression system was used to express human Era mutant and analyzed cell cycle of uninduced (add 1% ethanol) and induced (10μM Pon A) cell lines by flowcytometer, the primary results demonstrated human Era mutant could inhibit apoptosis induced by ethanol, and Era S36N may stimulate the expression of Bcl-2 as detected by Western Blot.

在构建稳定高表达蜕皮激素受体基因的细胞株3V3的基础上,转染突变型人Era的表达载体进行压力筛选,对所得到的单克隆细胞株进行诱导与未诱导条件下细胞周期的分析,结果表明未诱导加酒精的对照细胞可以引起细胞凋亡,而Era诱导表达后可以显著抑制凋亡细胞的数量,Western表明Era S36N可以诱导细胞Bcl-2表达,提示人Era可能与细胞凋亡相关。

In summary, the BRD7 gene acted as a candidate of tumor suppressor gene with NPC. The overexpression of BRD7 can partly reverse malignant phenotype of NPC cell line. The suppression effect of BRD7 on NPC tumorigenesis my be achieved by recognizing acetylated histone peptide through their motif-bromodomain, then modulating gene transcription by taking part in histone acetylating and chromosome remodeling, finally influencing signal-transduction pathways.

综上所述,BRD7基因作为一个重要的鼻咽癌抑瘤基因侯选者,在鼻咽癌细胞中的过表达后,可导致鼻咽癌细胞 HNE蛋白质表达谱发生改变,逆转其恶性表型,其作用机理可能是:BRD7基因通过其功能域彭聪硕士学位论文10Bromodomain与乙酚化的组蛋白特异性结合,参于染色体的乙酚化,染色质的组装,从而影响基因转录的调控,最终影响细胞内的信号传导通路并实现对细胞周期的调控,从而发挥抑制鼻咽癌细胞生长的作用。

We show that the combined oxygen and carbon isotope systematics are identical to those of well understood Phanerozoic examples that lithified in coastal pore fluids, receiving a large groundwater influx of photosynthetic carbon from terrestrial phytomass.

被广泛报道的新元古代碳酸盐中13C/12C 比例的下降并非是碳周期的波动,它们更容易通过与显生宙样品类比来理解。这个结果可能表明,在前寒武纪晚期,受由能够进行光合作用的藻类、苔藓和真菌构成的一层贴地覆盖物的影响,当时的地球正在发生&绿化&。

In vivo, CXCR4-A549 and A549 cells were injected subcutaneously into nude mice(each group in 6).Four weeks later the mice were scarified and the tumors in situ and the lungs were taken out to be examined histologically.(3) Th cell cycle distribution was measured by flow cytometry to analyse the effect of SDF-1/CXCR4 in the cell proliferation and atoposis. The changes of the intracellular calcium concentration after SDF-1 activation were aslo measured by flow cytometry. Western blot was used to anlayse the phosphorylation of AKT and ERK, and the expression of MMP-2 and VEGF-C.

3为探讨SDF-1/CXCR4在肺癌侵袭和转移中的作用机制:①利用流式细胞仪检测CXCR4-A549与A549两组细胞的增殖和凋亡,分析上调CXCR4的表达后,对细胞生长周期的影响;②利用流式细胞仪检测两组细胞钙离子内流强度,分析SDF-1/CXCR4对钙离子通道活性的调控;③采用Western blot实验检测两组细胞PI3K/AKT、MAPK/ERK相关信号通路的活性,分析SDF-1/CXCR4可能激活的下游信号分子;④采用Western blot和RT-PCR检测两组细胞肿瘤转移相关基因VEGF-C、MMP-2的表达,探讨SDF-1/CXCR4与VEGF-C、MMP-2的相互作用关系。

Based on the research, this dissertation has studied the M/G/1 and GI/GI/1 queueing systems, and drew the following conclusions: Firstly, we present the equation which satisfies the transient distribution of the lengthof L(T,θ1,θ2 for GI/G/1 queueing systems, and proves that the lengthL(t,θ1,θ2 for GI/G/1 queueing systems satisfy two types of equation, and aretheir minimal nonnegative solutions. Furthermore, we give out not only the expression of Laplace transformation, but also the expression of Laplace transformation of busy-idle period, as well as the equation that satisfies the waitingtime of W

第一,首先给出了GI/GI/1排队系统队长L(t,θ_1,θ_2的瞬时分布所满足的方程,证明了GI/GI/1排队系统队长L(t,θ_1,θ_2的概率分布满足二种不同方程,并且是这些方程的最小非负解,进一步给出了其拉氏变换的表达式,还给出了闲忙周期的拉氏变换的表达式,同时对等待时间W(t,θ也作了同样的处理。

The purpose of this thesis is to reserch and design a digital fish torpedo SONAR pulse detect system, to solve some defect which exist in traditional SONAR, to accomplish real-time detect the aim and judge the aim's type and estimate the center frequency, angle, dsintance, repeat period of target, to follow the fast moving target, as well as to adapt the system to different flank three sub-array types without the limitation of installation place.

本文的目的在于研究并设计数字式鱼雷声纳脉冲侦察系统,解决传统声纳中存在的一些弊端,实现对鱼雷脉冲信号的实时检测,以及对信号的种类,中心频率,目标的方位,距离信息,重复周期的估计,对快速运动目标的跟踪测距,使系统不受安装场合的限制,适用于不同的舷侧三元子阵。

Recently, an active industrial capital to the current market downturn is a beautiful scenic routes, industry experts believe that, with the economic downturn led a further decline in stock prices, with excellent performance, characterized by scattered equity of listed companies is bound to attract industrial capital to carry out mergers and acquisitions, from a long-cycle perspective, the current A shares have investment value.

马英九从举牌羚锐股份增持长镜头,以冀东水泥海螺水泥,常常万亿投资购买渤海物流股份深国商商业城和天音在2000年,大股东回购股票,以加强控制等,最近活跃产业资本对当前市场的低迷是一个美丽的风景线,业内专家认为,随着经济的下滑导致股票价格进一步下跌,具有优良的性能,特点是分散上市公司的股权,势必吸引产业资本进行兼并和收购,从长周期的角度来看,目前A股的投资价值。

As entering the knowledge economy time, enterprises have to face the market fast changing, product life cycle reducing, the technology promotion speeding up, the product function becoming more complex day by day as well as the product development becoming more and more difficult, how to speed up the research and development, reduce the time before promoting the product to the market, expand the market share, promote the ability of technology innovation, then obtain the long-enduring developmented core-competence become each enterprise to have to face with a question.

知识经济时代企业面对市场的瞬息万变、产品生命周期的缩短,技术更新的速率加快,产品功能的日趋复杂以及产品开发难度的提升,如何加快产品的研发,缩短产品的上市时间,扩大市场占有率,提升企业技术创新的能力,从而获得可持续性发展的核心竞争力成为每个企业都必须面对和解决的问题。

The enterprise core competitive power in 1990, US managed scholar pula Harder and Hammer famous you proposed the core competitive power concept, they believed, along with the world development change, the competition intensified, the product life cycle reduction as well as the global economic integration enhancement, enterprise's success no longer gave credit to the market strategy which or got a sudden inspiration in short either the accidental product development, but was the enterprise core competitive power external performance.

企业核心竞争力 1990年,美国著名管理学者普拉哈德和哈默尔提出了核心竞争力的概念,他们认为,随着世界的发展变化,竞争加剧,产品生命周期的缩短以及全球经济一体化的加强,企业的成功不再归功于短暂的或偶然的产品开发或灵机一动的市场战略,而是企业核心竞争力的外在表现。

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