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The article in recent years the research progress of disease of oral cavity of TP prevention and cure makes one overview. The compositive TP of the basic research 1.1 TP of 1 TP is the floorboard that phenolic apperception of a kind of many hydroxyl closes matter, 25% what hold tea dry weight about, its are main component includes to express gallnut of gallnut catechu element gallnut of element of catechu of gallnut of acerbity ester, watch, watch catechu element is acerbity element of catechu of ester, watch, express gallnut of gallnut catechu element among them acerbity ester content is highest, occupy the 80%[1] of catechu element about, fighting oxidation with its unique element structure, fight the position with fight the respect such as tumor to have choppy, significant. The 1.2 TP absorption in oral cavity and metabolization Lee [2] is measured normally inside a hour after healthy person is chewing green tea Xie Huo contains juice of gargle green tea, content of the TP in saliva is very high, after observing green tea passes salivary enzymatic hydrolyze, TP is slow release and in oral cavity;Yang of local play action [the salivary level after 3] checked 6 volunteers to drink tea, chroma of the TP in making clear the saliva after drinking tea as a result is serous TP pH indicator 2 times, and the salivary TP concentration that contains gargle tea solution a few minutes to be able to produce higher level, and TP can be absorbed through oral cavity mucous membrane.

本文就近年来TP防治口腔疾病的探究进展作一综述。1 TP的基础探究1.1 TP的组成TP是一类多羟基酚类化合物的总称,约占茶叶干重的25%,其主要成份包括表没食子儿茶素没食子酸酯、表没食子儿茶素、表儿茶素没食子酸酯、表儿茶素等,其中表没食子儿茶素没食子酸酯含量最高,约占儿茶素的80%[1],并以其独特的分子结构在抗氧化、抗突变、抗肿瘤等方面占有重要的地位。1.2 TP在口腔中的吸收和代谢Lee等[2]测得正常健康人在咀嚼绿茶叶或含漱绿茶液后的一个小时内,唾液中TP含量很高,并观察到绿茶通过唾液酶水解后,TP缓慢释放并在口腔局部发挥功能;Yang等[3]检查了6位志愿者饮茶后的唾液水平,结果表明饮茶后唾液中TP浓度是血浆TP浓度的2倍,而含漱茶溶液几分钟即可产生更高水平的唾液TP浓度,且TP可通过口腔黏膜吸收。

The research results indicated that the best base was KOH, the best acid was H3PO4 and their neutralizing products were the necessary nutrients for foliar fertilizer; 12.4 L of foliar fertilizer were obtained in per kg of shrimp offal, chitin was obtained in 13.8% yield, crude protein was obtained in 23.2% yield using this method; This multifuctional foliar fertilizer was an abundant nutritional multifunctional foliar fertilizer which contained 15 kinds of amino acids, shimp cephalin, astacein and many trace elements. The concentration of calcium was 38.9 mg/L, the concentration of magnesium was 55.4 mg/L, the concentration of potassium was 20.0 g/L, the concentration of nitrogen was 4.5 g/L and the concentration of phosphorus was

研究结果表明:(1)处理虾下脚料的最佳碱是KOH,最佳酸是H3PO4,其中和产物是叶面肥必需的营养素;(2)本工艺不仅每Kg虾下脚料可制备虾叶面肥12.4L,而且可回收13.8%甲壳素和23.2%粗蛋白质;(3)经分析测定虾叶面肥中,含钙(Ca2+)38.9 mg/L,含镁(Mg2+)55.4 mg/L,含钾20.0 g/L,含氮4.5 g/L,含磷 78.9 g/L,还含有15种氨基酸及虾脑磷脂、虾红素及多种微量元素等,是一种营养丰富的多功能叶面肥。

A process for the carbonylation of allylic butenyl ether (for example, methyl crotyl ether, 3-methoxybutene-1 and mixtures thereof) or mixture of butadiene and alcohol and production of beta-gamma unsaturated carboxylic acid esters (for example, methyl-3-pentenoate) utilizing a rhodium-containing catalyst for example, dicarbonylacetylacetonate rhodium(I or the like promoted with an iodide-containing compound (for example, HI, AlI3, SnI4, TiI4, CrI3, and CoI2 or the like).

一种将烯丙型丁烯基醚(如甲基巴豆基醚、3-甲氧基丁烯-1及其混合物)或者丁二烯与醇的混合物羰基化的方法,以及由含碘化物化合物(如HI、AlI3、SnI4、TiI4、CrI3和CoI2或等效物)促进,用含铑催化剂如二羰基乙酰丙酮酸铑(I或其等效物制备β-γ不饱和羧酸酯(如甲基-3-戊烯酸酯)的方法。

With intermediates 1,ω-hexadecanediol and ω-bromo pentadecanol as starting materials,ω-bromo hexadecanoic acid and ω-bromo octadecanoic acid were prepared in four and seven steps of reactions separately.

分别以1,ω-十五烷二酸和1,ω-十六烷二酸为原料,各经过四步有机反应,制备了ω-碘代十六烷酸及含十四、十五、十六碳原子的ω-溴代直链脂肪酸;再以中间产物15-溴代十五烷醇、1,ω-十六烷二醇为原料,各经过四步、七步有机反应,制备了ω-溴代十六烷酸及ω-溴代十八烷酸。

Niobic acid as a solid catalyst can be directly applied in the hydrolysis, esterification, condensation and alkylation reaction etc.

铌酸可直接作为固体催化剂,应用于水解、酯化、缩合、烷基化等反应中;铌酸也作为载体负载金属,应用于F-T合成、氧化反应和加氢等反应中;含铌化合物也可作为负载型催化剂,负载到不同类型的载体上;含铌化合物也作为助剂或光催化剂,广泛地应用于催化多种化学反应。

Flame—retardant resin was prepared by the condensation and polymerization of phosphoric acid, trihydroxy methyl propane and epoxy chloropropane,the resin was then reacted with hexane diacid and diglycol under certain condition ,resulting in polyol containing 1.5% P and 17— 18% polyester polyol, which was foamed with polyisocyanate, water and catalyst by one— step method, producing fire...

通过磷酸、三羟甲基丙烷和环氧氯丙烷的缩合和聚合反应制得阻燃树脂,然后将它与己二酸、一缩二乙二醇在一定条件下反应制得含P1.5%和含Cl17~18%的聚酯多元醇,再将它与多异氰酸酯、水、催化剂等组分采用一步法发泡工艺制得阻燃聚氨酯软泡塑料。

Flame— retardant resin was prepared by the condensation and polymerization of phosphoric acid, trihydroxy methyl propane and epoxy chloropropane,the resin was then reacted with hexane diacid and diglycol under certain condition ,resulting in polyol containing 1.5% P and 17— 18% polyester polyol, which was foamed with polyisocyanate, water and catalyst by one— step method, producing fire—resistant PU soft foam.

通过磷酸、三羟甲基丙烷和环氧氯丙烷的缩合和聚合反应制得阻燃树脂,然后将它与己二酸、一缩二乙二醇在一定条件下反应制得含P1.5%和含Cl17~18%的聚酯多元醇,再将它与多异氰酸酯、水、催化剂等组分采用一步法发泡工艺制得阻燃聚氨酯软泡塑料。

Examples of metal chelating groups include hydroxides especially aryl or heteroaryl hydroxides such as phenolic hydroxides; amines which may be aliphatic aryl or heteroaryl; mercaptans which may be aliphatic aryl or heteroaryl; carboxylic acids which may be aliphatic aryl or heteroaryl; oximes and ketoximines; acetarylamides; hydroxy silanes and silicones; N-containing heterocycles such as imidazoles benzimidazoles triazoles benzotriazoles thiazoles isothiazoles acid anhydrides and more preferably acid groups (especially carboxylic acid groups phosphoric acid groups polyphosphoric acid groups phosphonic acid groups sulphuric acid groups and sulphonic acid groups).

金属螯合组的例子包括氢氧化物,特别是芳基或如酚醛氢氧化物杂氢氧化物;胺可能是脂肪族,芳基或杂;硫醇可能是脂肪族,芳基或杂,这可能是脂肪族,芳基或羧酸杂;肟和ketoximines; acetarylamides;羟基硅烷和有机硅,含N,如咪唑,苯并咪唑类,三唑类,苯并三氮唑,噻唑类,isothiazoles,酸酐杂环,多最好酸组(特别是羧酸团体,磷酸,团体,多聚酸组,膦酸组,硫酸团体和磺酸组)。

In the body and animals, dimethyl sulfone is one of the main sources of sulfur that is in the synthesis of methionine, cysteine , sulfur-containing tissue, protein and peptide.

二甲基砜是人体、动物等合成蛋氨酸、胱氨酸和含硫肽、蛋白,以及含硫组织中硫的主要供应源之一。

Results were shown as followings:(1) Sodium selenite at 0~2.5 μmol/L significantly increased the antioxidative capacity of L-02 cells without having remarkable impact on SMMC-7721 cells;(2) Sodium selenite at concentrations above significantly increased telomerase activity, hTERT gene expression and telomere length of L-02 cells without significant impact on SMMC-7721 cells;(3) Sodium selenite at higher concentrations (larger than 5 μmol/L) resulted in peroxidation of L-02 cells, while scutellarin significantly counteracted its effect;(4) Selenium-rich amino acids from silkworm pupas in the range of 0.5~2.5 μmol/L Se significantly inhibited SMMC-7721 cell growth, induced apoptosis and cell cycle change, and the generation of reactive oxygen species. In contrast, sodium selenite and selenomethionine only had weak impact on them at the same concentrations;(5) A new selenium-containing protein was found from selenium-rich silkworm pupas, which is worthy to be study further;(6) An expression vector containing ansense RNA of hTERT gene were constructed and used to transfect SMMC-7721 cells. They were observed to inhibit hepatoma cells.

结果如下:(1)0~2.5μmol/L亚硒酸钠显著性增强L-02细胞的抗氧化能力;而对SMMC-7721细胞的作用不显著;(2)该浓度硒显著性提高L-02细胞端粒酶活性、增强hTERT基因表达和延长细胞端粒长度;而对SMMC-7721细胞的作用均不显著;(3)高浓度硒(5μmol/L以上)显著性抑制L-02细胞生长、致细胞过氧化,灯盏花素能拮抗硒所致过氧化、降低硒毒性;(4)0.5~2.5μmol/L富硒蚕蛹氨基酸显著性抑制肝癌细胞SMMC-7721生长、导致细胞凋亡和周期改变、诱导细胞产生活性氧,同浓度亚硒酸钠和硒代蛋氨酸对其抑制不显著;(5)富硒蚕蛹蛋白经分离纯化和鉴定后发现存在一新含硒蛋白,其结构和功能有待研究;(6)通过已有的含hTERT基因质粒,成功构建hTERT反义RNA表达质粒,转染SMMC-7721细胞后对其生长具有抑制作用。

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