吡啶

Synthesis process Molecular Formula:〓 Molecular Weight: 394 Chemicla name: N-(2, 3-dihydro-2, 7-dimethyl-benzofuran-1-acyl)-N'-tert-butylN'-(3, 5-dimethyl benzoyl) hydrazine Structural formula:〓 This article define a synthesis method of JS118 with (2, 3-dihydro-2, 7-dimethylbenzofuranyl)-6-formic acid, tert-butyl hydrazine hydrochloride acid and 3, 5-dimethyl benzoic acid as main intermediate through four steps of reaction involving, acyl chloridation condensation and so on.

本文主要的研究工作内容：(1)以N-特丁基双酰肼为先导结构，利用分子等排原理和类同合成法进行先导设计，有目的、有选择地重点改变R〓、R〓基团，将具有不同取代基的苯环以及呋喃环、苯并呋喃环、吡咯环、吡啶环等杂环、稠杂环与先导结构进行有机的组合。

These experiments suggest that this dihydropyridinesensitive isoform of the mbC α1 subunit is functional in the transfected chromaffin cells and that the number of calcium channels is a limiting component in the secretion from chromaffin cells in culture.

这些实验结果推论这个小鼠脑中的对双氢吡啶敏感的mbC钙离子通道是L-型钙离子通道，并在转化的肾上腺嗜铬细胞中具有功能活性，而且说明钙离子通道的数目对培养的肾上腺嗜铬细胞的分泌是个限制因素。

In the presence of CPB, the chromogenic reaction of V with DPCO has been studied.

研究在溴化十六烷基吡啶存在下，钒与二苯偶氮羰酰肼显色反应的分析特性。

With the molar ratio of cobaltous nitrate, phenanthroline and Pyridine-3,4-dicarboxylic acid is 1∶2∶1,under the condition of pH=5,heating at 50-60℃ and stirring,the ternary complex of cobalt is synthesized in the methanol solution.

将硝酸钴、邻菲罗啉和3，4-二羧基吡啶按1∶2∶1物质的量比计量，在pH=5和50-60℃加热搅拌的条件下，在甲醇溶液中合成了钴的三元配合物，用元素分析、红外光谱、紫外光谱、热重分析和摩尔电导率对配合物进行表征，结果表明该配合物为1∶1型电解质，其组成为[CoⅢ2]NO3.H2O，其中Pydc=

Application of organic acid catalysis to the polymerization of pyrroles and pentafluorobenzaldehydes, with the xylene as reaction medium instead of expensive collidine used in the conventional methodology, resulted in a relatively high yield of TPFPPH〓.

本研究利用有机酸如氯乙酸催化吡咯和五氟化苯甲醛聚合，并以二甲苯替代传统方法所用的昂贵溶剂2，4，6-三甲基吡啶，获得了产率较高的TPFPPH〓。

63 patients with UC which type is humid heat are randomly divided into two groups with the herb medicine group 33 which are treated with " Qing Hua Chang Yin " oral administration and " Guang Chang Number1 Decoction " coloclysis, while the control group 30 which are treated with Salazosulfapyridine.

资料与方法：确诊为湿热型溃疡性结肠炎患者63例作为研究对象，随机分成对照组及治疗组，对照组30例、治疗组33例。其中对照组用柳氮磺胺吡啶口服及灌肠，治疗组用清化肠饮口服配合灌肠Ⅰ号方灌肠。

The rat model of ulcerative colitis was established by coloclysis of 100 mgkg^(-1) TNB. From the third day, except for the normal group, each group was treated with an enema of 0.9% NaCl, SASP,"Qingchang Suppository" respectively. The rats were sacrificed seven days later.

用TNBs 100mg/kg灌肠建立大鼠溃疡性结肠炎模型，第3d开始，除正常组外，各组分别给予生理盐水、柳氮磺胺吡啶、清肠栓灌肠处理，7d后处死动物，分别检测大鼠肠组织中的淋巴细胞凋亡和血清IL-1β、IL-13的含量。

Compare to SASP," Qing Hua Chang Yin " oral administration and " Guang Chang Number1 Decoction " coloclysis cure humid heat's UC shows more curative effect and safety, few adverse reaction.

&清化肠饮&口服配合&灌肠Ⅰ号方&灌肠治疗湿热型溃疡性结肠炎与&柳氮磺胺吡啶口服及灌肠&治疗相比，更具疗效且临床使用安全、副作用少。

114 cases ulcerative colonitis from jan. 2005 to dec. 2008 in our hospital were divided into two groups. 63 cases in treatment group were given herbal decotion, 51 cases in control group were given sulfasalazine orally with succinic acid hydrogenation cortisone edema.

选择2005年1月至2008年12月来我院就诊的溃疡性结肠炎患者114例，随机分为两组，治疗组63例服用自拟中药汤剂治疗；对照组51例采用柳氮磺胺吡啶口服，琥珀酸氢化可的松灌肠。

The model mice were then treated by giving GDNF into the striatum. After a seven-day survival period, the model mice were sacrificed to get the segment of substantial nigra fixed, embedded and coronally sectioned continuously. The microsections were processed by immunohistochemistry using anti -TH and anti-CB antibodies to label DA neurons and CB-containing neurons respectively, which were counted under microscope and analyzed statistically.

利用1-甲基－4-苯基1，2，3，6-四氢吡啶(1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine，MPTP)制备成年小鼠PD模型，通过单侧纹状体定位注射GDNF，取中脑黑质节段，做连续冠状石蜡切片，结合免疫组织化学染色方法，观察各组酪氨酸羟化酶(tyrosine hydroxylase，TH)、钙结合蛋白(calbindin D28k，CB)的表达，光镜观察并细胞计数，统计学分析。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。