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ChinaObjective:To study the antitoxic role of vesicular monoamine transporter 2 (VMAT2) in transpgenic Chinese Hamster ovary cell.Methods:With the technology of transgene from PC12 to CHO,MTT reduction assay was used to detect MPP^+ toxic effect on wild type CHO and transgenic CHO.

利用转PC12细胞基因到CHO细胞中形成的转基因CHO细胞(cDNACHO,采用MTT比色法检测1-甲基-4-苯基吡啶离子(MPP^+对CHO细胞野生株(wtCHO和cDNACHO细胞的毒性作用,并观察利血平-VMAT2的特异性阻滞剂对MPP^+毒性作用的影响。

Methods 63 cases of coxa arthropathy associated with AS were divided into two groups,experimental group and control group.Both groups received a basal treatment of taking sulfasalazine and nabumetone.In EG intra-articular injection of sodium hyaluronate and was carried out once a week in 33 patients with coxa arthropathy associated with AS.Each case received 5 injections in all,only in first injection combined with compound betamethasone.

63例强直性脊柱炎伴髋关节病变患者随机分为两组,均在给予柳氮磺吡啶1.0g,每日2次及萘丁美酮1.0g,每日1次的基础治疗上,试验组患者进行玻璃酸钠和复方倍他米松髋关节腔内注射,每周1次,第1周同时注射两种药物,后第2~5周,仅注射玻璃酸钠,而对照组仅于疗程第1天给予复方倍他米松肌肉注射1次,连续5周为1个疗程。

N-succinimidyl 5---3-pyridinecarboxylate, a useful linker for labeling proteins with astatine and iodine radioisotopes, is synthesized in three steps with 5- bromonicotinic acid as a starting material, and is characterized by nuclear magnetic resonance, mass spectrometer and high performance liquid chromatography.

以5-溴烟酸为起始物,通过3步主要反应合成了一种适用于蛋白质放射性砹标记的偶联剂——5--3-吡啶甲酸 N-琥珀酰亚胺酯,并用核磁共振、质谱、高效液相色谱等进行了表征。

Ventionsstudie, DHP ( 10 ) and the MONICA Augsburg Study ( 11 ), both of which focused on cardiovascular diseases and risk factors.

ventionsstudie,二氢吡啶)(10)和莫尼卡奥格斯堡研究(11),两者都对心血管疾病和危险因素的重点。

Combining with the Laiwu City construction plan, this article studies on the project feasibility of 1,000 tons three chlorine azine alcohol sodium annual in Lai Wu City X chemical industry Ltd.

本文对目前农药中间体生产及供运现状的统计和分析,应用可行性研究的方法和步骤,结合莱芜市的建设规划,对莱芜X化工有限公司1千吨/年三氯吡啶醇钠生产项目进行了可行性研究。

Synthesis of Rare Earth Complexes with 2,6-Dicarboxilic Acid Pyridine-N-Oxide and the Study of Their Bacteriostatic Effect.

张永平,韩俭,唐宁,等。2,6-二甲酸吡啶氮氧化物稀土配合物的合成及其抗菌活性的研究。

A series of N-bonded donor-acceptor derivatives of phenothiazine containing benzene, anisole, pyridine, naphthalene, acetophenone, and benzonitrile as an electron acceptor was synthesized.

合成了一系列的N-10位取代的吩噻嗪给体受体化合物,这些受体包括苯、苯甲醚、吡啶、萘、苯乙酮和苯乙腈。

The optimal separating condition of chromatography analysis was: Shimadzu VP-ODS 150mm4.6mm as chromatographic column; acetonitrile/water (12/88,V/V, Contained 1.25mmol/l phosphoric acid) as mobile phase with flow rate of 1.0ml/min. Macroporous ion exchange resins and activated carbon were applied to enrich the trace level impurities and the main impurities was determined by LC-MS and GC-MS.They were : Benzonitrile , 2-Methyl-8-hydroxyquinoline, 2,6-Pyridinediamine , O-ethyloxime Cyclo-hexanone and compound with 220 molecular weight .

采用离子树脂和活性炭吸附富集这些微量的杂质,并通过液质联用和气质联用对杂质进行了定性分析,鉴定了影响290nm吸收的主要杂质为苯甲腈,2甲基-8羟基喹啉,2,6二氨基吡啶,O-乙基环己酮肟和分子量220的物质。

Using benzyl phosphorus and pyridine phosphorus ligands, a series of complexes were synthesized and their structures were also discussed.

使用苯基膦酸以及吡啶膦酸配体合成了一系列链状和层状配合物,并对它们的结构进行了研究。

METHODS 3-methoxy-7α-methylestra-1,3,5(10)-trien-17β-ol was reducted with lithium and ammonia,then the intermediate was hydrolyzed in oxalic acid and reacted with malonic acid to get 3,3-dimethoxo-7α-methylestra-5(10)-en-17-ol(compound 4),which was oxidated by pyridium bichromate ,reacted with acetylene,and hydrolyzed in oxalic acid again to get the product tibolone.

方法以3-甲氧基-7α-甲基雌甾-1,3,5(10)-三烯-17β-羟基为起始原料经锂胺还原、草酸水解、缩酮化得3,3-二甲氧基-7α-甲基雌甾-5(10)-烯-17β-羟基(化合物4),然后用温和的氧化剂重铬酸吡啶盐氧化、炔化、再水解得目的产物。

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