吡啶

Methods Starting from 2-chloro-4-nitrophenol and 2- pyridine hydrochlorid, 3-chloro-4-(pyridin-2-ylmethoxy) aniline was obtained via etherization and reduction. The obtained aniline coupled with N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide to give 4-[3-chloro-4-(2-pyridylmethoxy) phenylamino]-3-cyano-7-ethoxy-6-N-acetylaminoquinoline. And then it was deacetylated, followed by reacting with4- but-2-enoyl chloride to yield the target compound neratinib.

以2-氯－4-硝基苯酚和2-氯甲基吡啶为起始原料，经醚化、硝基还原得到3-氯－4-（吡啶－2-甲氧基）苯胺，3-氯－4-（吡啶－2-甲氧基）苯胺与3-氰基－6-乙酰氨基－7-乙氧基－4-氯喹啉反应得到3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉，3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉去乙酰保护基后，与-4-二甲氨基－2-丁烯酰氯经酰化反应得到ner-atinib。

This invention is directed to the-tartaric acid salt of 2-amino-N-{1-(2,4-difluoro-benzyloxymethyl)-2-oxo-2-3-oxo-3a-pyridin-2-ylmethyl-2-(2,2,2-trifluoroethyl-2,3,3a, 4,6,7-hexahydro-pyrazolo(4,3-c) pyridin-5-yl-ethyl}-2-methyl-propionamide which is a growth hormone secretagogue and as such is useful for increasing the level of endogenous growth hormone.

本发明涉及2－氨基－N－{1－－(2，4－二氟－卞氧甲基)－2－氧代－2－3－氧代－3a－(R－吡啶－2－基甲基－2－(2，2，2－三氟－乙基)－2，3，3a，4，6，7－六氢化－吡唑子基(4，3－c)吡啶－5－基－乙基}－2－甲基－丙酰胺的－－酒石酸盐，它是一种生长激素促分泌素，并且可用于提高内源性生长激素水平。

A series of N-bonded donor-acceptor derivatives of phenothiazine containing benzene, anisole, pyridine, naphthalene, acetophenone, and benzonitrile as an electron acceptor was synthesized.

合成了一系列的N-10位取代的吩噻嗪给体受体化合物，这些受体包括苯、苯甲醚、吡啶、萘、苯乙酮和苯乙腈。

The functional groups which are placed at 4-position of pyridine-2,6-dicarboxylic acid can effect the electron cloud of the lanthanide complexes.

吡啶-2，6-二甲酸的4位取代官能团能影响配合物的电子云形状，配合物的荧光性能和电子能量传递密切相关。

Dissolve in ethanol, ethyl ether, chloroform and other organic solvents.

1，4-二［2-（4-吡啶）乙烯基］－苯是一种暗红色固体。

GC/MS analysis on the leaf oil indicated that the main components with a relative content of ≥3% were alloocimene (43.22%),α-pinene (13.63%),γ-terpinene (5.49%),-3, 7-dimethyl-, 2, 6-octadien-1-ol (3.58%),β-fenchyl alcohol (4.58%), and 2-amino-3, 5-dicyano-6-(4-methoxyphenoxy)-pyridine (3.67%).

用GC/MS联用方法，对巨尾桉挥发油进行鉴定，相对百分含量在3%以上的化合物有：α-蒎烯(13.63%)、别罗勒烯(43.22%)、γ-萜品烯(5.49%)、3，7-二甲基－2，6-辛二烯醇(3.58%)、β-小茴香醇(4.58%)和2-氨基－3，5-二氰基-6-（4-甲氧基苯氧基）－吡啶(3.67%)。

The quantitative determination method of potassium ferrocyanide in edible salt is described in the paper.

本方法采用蒸馏食用盐中亚铁氰化钾，吸收氰根，吡啶-吡唑啉酮显色定量测定。

The tobacco-specific nitrosamine 4--1-(3-pyridyl)-1-butanol is present in the urine of tobacco users and, at lower concentrations, in the urine of nonsmokers exposed to secondhand smoke.

烟草特有的亚硝胺4--1-(3-吡啶)-1-丁醇存在于吸烟者和被动吸二手烟的非吸烟者人群的尿液中，只是被动吸二手烟的非吸烟者人群尿液中的浓度更小。

Two kinds of dsDNA intercalating fluorescent dyes, [Ru2]2+(phen = 1,10-phenanlinthroline; dppz = dipyrido [3,2-a:2',3'-c] phenazine) and BOBO-3 2,2\'-1,3-propanediylbis[(dimethyliminio-3,1-propanediyl -1(4H)-pyridinyl-4-ylidenemethy-lidynebis[3-methyl]-benzothiazoe were employed in this chapter, and two non-covalent labeled fluorescence sensing systems for thrombin determination were successfully developed and compared based on its 29-mer aptamer.

本章利用dsDNA嵌入式荧光染料[Ru2]2+(phen = 1，10-二氮菲； dppz =吡啶[3，2-a：2'，3'-c]吩嗪)及BOBO-32，2\'-1，3-丙二基二[(二甲基亚氨基-3，1-丙二基-1(4H)-吡啶基-4-(丙-1，3-二烯基二[3-甲基]-苯并噻唑)，基于适配体29-mer，分别建立了两种凝血酶检测体系[Ru(phen2]2+及BOBO-3检测体系。

NMR and ESI-MS techniques were used to study the interactions between diperoxovanadates and small organic molecules such as pyridine, imidazole, arginine, picoline ester, and picoline amide. Spectroscopic methods were established to explore this type of interactions.

在合成数种双过氧钒化合物的基础上，利用多种NMR技术结合ESI-MS等谱学方法系统研究了双过氧钒化合物和咪唑、吡啶、取代吡啶、精氨酸、皮考啉酯以及皮考啉酰胺等有机配体的相互作用，建立了一套适合研究过氧钒化合物与有机小分子相互作用的谱学方法。

Liapunov—Schmidt method is one of the most important method in the bifurcation theory.

Liapunov—Schmidt方法是分叉理论的最重要方法之一。

Be courteous -- even when people are most discourteous to you .

要有礼貌──即使当別人对你最不礼貌的时候。