吗啡作用

Extensive sprouting of sensory afferents and hyperalgesia induced by conditional expression of nerve growth factor in the adult spinal cord.

传统观点认为，蓝斑核是介导吗啡戒断反应的主要部位，但大量研究表明，作为联系外周神经和高位中枢纽带的脊髓在吗啡戒断反应中发挥重要作用[18-20]。

Of naltrexone and morphine chemical structure similar to morphine poisoning but it there is a flip effect.

纳曲酮的化学结构与吗啡相似，但它对吗啡中毒者却有一种翻转作用。

Results Morphine and purine nucleotide interventions improved the inhibition of morphine on PC12 cell proliferation.

结果 同时给予吗啡和嘌呤核苷酸可改善吗啡对PC12细胞增殖的抑制作用。

Agmatine co-treated with morphine could reverse morphine's regulation on NMDA receptors' expression in these two regions.

胍丁胺与吗啡伴随给药能逆转吗啡对两脑区NMDA受体蛋白表达的调节作用。

These findings suggest that NC (13-17) may play important roles in pain modulation at supraspinal level in mice and elicits these effects through a novel mechanism independent of the NC receptor and the traditional opioid receptors The bioactivity study of NC related peptide-NST showed that: NST could dose-dependently reverse the effects of NC in antagonizing EMs-induced analgesia; NST itself could increase the MAP and HVBR of rat, and the tension of rabbit isolated aorta muscle strips.

对孤啡肽相关肽—NST的生理活性研究发现，NST可以剂量依赖的拮抗NC对抗内吗啡肽-1和内吗啡肽-2的镇痛作用；NST对NC的降低大鼠平均动脉压作用无显著影响，但其本身可以升高大鼠的平均动脉压，后肢灌流压和离体血管条的张力，在心血管系统方面是一个新的生物活性肽。

These results suggest that morphine withdrawal selectively impairs the cued fear extinction through inhibiting the ERK phosphorylation in the amygdale and mPFC. Histamine deficiency not only enhances acquisition the cued and contextual fear conditioning and but also potentiates the impairment of extinction of cued fear memory.

这些结果提示：吗啡戒断能选择性抑制恐惧记忆的消除，此作用是通过抑制杏仁核和mPFC脑区内ERK蛋白磷酸化来实现的；组胺缺乏能增强线索和背景恐惧记忆的获得以及增强吗啡戒断对线索恐惧记忆消除的抑制作用。

Histamine deficiency markedly potentiated the acquisition of learning in cued and contextual fear conditioning in the HDCKO mice,but had no effect on cued and contextual fear extinction.However,histamine deficiency potentiated the inhibitory role of morphine withdrawal in cued fear extinction.Consistent with the behavioral results,morphine withdrawal decreased ERK phosphorylation in the amygdala and mPFC but not in the hippocampus of WT and HDCKO mice,and ERK might not be phosphorylad in the amygdale and mPFC of HDCKO mice after the 4th training of cued fear extinction.

但HDCKO小鼠增强了吗啡戒断对线索恐惧记忆消除的抑制作用，与行为学实验结果相一致是，，吗啡戒断能明显降低WT和HDCKO小鼠在线索恐惧记忆消除第4次训练后杏仁核和mPFC脑区的ERK磷酸化水平，但对海马脑区的ERK磷酸化没有作用；HDCKO小鼠在线索恐惧记忆消除训练的第4次训练后杏仁核、mPFC脑区的ERK蛋白没有明显磷酸化激活。

The results obtained suggest that like the analgesic action of morphine, there is an antagonistic modulation by monoamines of morphineinduced respiratory depression, i. e. 5-HT and DA function as the depressant mediators and NE as an excitatory mediator, and that a central #alpha#-adrenergic system is involved in the action of morphine on the respiratory centers.

上述结果提示中枢内存在的单胺类拮抗性调制系统在吗啡的呼吸抑制效应中起一定作用，5-经色胺和多巴胺系统加强吗啡的呼吸抑制效应，去甲肾上腺素系统则相反，后者的作用是通过，一受体而不是户受体实现的。

The ipsilateral microinjection of γ aminobutyric acid of morphine hydrochloride into the nucleus tractus solitarius blocked partly the evoked bradycardiac and depressor responses without any influence on basal blood pressure and heart rate.

NTS内注射GABA受体拮抗剂荷苞牡丹碱可拮抗吗啡的上述作用，但吗啡受体拮抗剂纳络酮几乎不影响GABA对诱发压力感受性反射的阻断效应。

Morphine of rule dose can significantly increase SOBP, SOCA, SOF and CBDP, anisodumine and magnesium sulfate can resist the exciting role of morphine on SO.

常规剂量的吗啡，可提高胆总管压、SO基础压、收缩波幅及收缩频率；山莨菪碱、硫酸镁可以拮抗吗啡对SO的激动作用。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐