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On the establishment of shielding immune cells avoid HIV viral antigens identified protein adsorption and the establishment of "biological trap" induce HIV models Summary : HIV is the human immunodeficiency virus caused AIDS virus, AIDS is not currently be fully human control, AIDS vaccine is being developed, but because the virus genetic diversity potential to change the topic of the complexity of this ban from the incidence of HIV spread T4 cells in the mechanisms by, proposed changes T4 lymphocyte surface protein CD4 receptors structure as to avoid HIV adsorption, and the establishment of "biological trap" booby HIV idea to try to turn on AIDS treatment to the conversion of protein structure and function, as well as synthetic direction.

提要:HIV即人类免疫缺陷病毒是引起AIDS的病毒,目前爱滋病还不能被人类完全控制,AIDS的疫苗也正在研制中,但是由于病毒多样性的遗传潜能,使这一课题变的很复杂,本文试从HIV侵染T4细胞导致发病的机理入手,提出改变T4淋巴细胞表面CD4受体蛋白构象以避免HIV吸附,并设置"生物陷阱"诱杀HIV的构想,试图把对爱滋病的治疗引向对蛋白质结构与功能转化以及合成的方向。

The histopathologic observations of corneas after penetrating keratoplasty in dogs: Thestructure of wholly transparent graft was the same as that of host cornea apart from the upperdonor-host junction where there was minimal irregularity of the corneal lamellae. However, thecorneal lamellae at the lower donor-host junction were neat. The graft with its central part beingtransparent only showed poor coaptation with recipient, in which the graft shifted inward and had marked wrinkles and folds in Descemet"s membrane. On the back of Descemet"s membranethere was hyperplastic stromal fibers that thickened the graft and partially adhered to iris.

5犬穿透性角膜移植术后角膜病理组织学观察完全透明的植片与植床结构一致,仅两者对合处上部纤维紊乱,而下方纤维排列整齐;中央透明的植片与植床对合不良,植片向植床方向嵌入,后弹力层皱缩、折叠,植片下方因有来自植床的基质纤维而增厚,部分对合处与虹膜粘连;浑浊的植片有比较完整的上皮层,植片约2/3深度的基质丧失原来纤维整齐排列结构,代以大量成纤维细胞增生。

In blastula embryos and 50% epiboly embryos, the zygotic pou2 transcript is also distributed in every blastomere cell. At the stage of 90% epiboly, expression of pou2 converges to the dorsal midline of embryos and locates in two waves of lateral neural plate and two transverse stripes in the brain region. In embryos at 100% epiboly, pou2 transcript is restricted in the neural plate and areas of presumptive midbrain amid himdbrain. From somite stage, gibel carp pou2 can not be detected any more, which is consistent with the RT-PCR result.

在高囊胚期和50%下包期,高度表达的合子转录本仍在所有的胚盘细胞中,但至90%下包期时,pou2的表达向胚胎背部的正中线汇聚,集中在神经板的两侧区域和脑部的两条横向条带在100%下包期时,pou2的表达集中在神经板的中间区域以及预期形成的中后脑区域至体节期时,转录本消失,这与RT-PCR结果高度一致。

In our experiments, when the opacity of lens exceed Ⅳ degrees, the treatment effect of medicine was not obviously. Analyzing the examined results of AR, SOD and GSH-px in rat lens cortex and nuclear shows that Zhangming drops can inhibit the activity of AR obviously and prevent the translation of galactose to galactose alcohol. So it can prevent the deposit of galactose in the fibrocyte of lens and the increase of lens's osmosis, then prevent the hydration of lens.

通过对大鼠半乳糖性白内障晶体皮质和核内醛糖还原酶、超氧化物歧化酶和谷胱苷肽过氧化物酶的检测结果分析表明,障明滴眼液能明显抑制AR的活性,防止半乳糖向半乳糖醇的转化,从而防止半乳糖在晶体纤维细胞内的堆积,阻止其渗透性的增高,防止晶体的水化。

Clinical Efficiency of Meningococcus Group A Capsular Polysaccharide Vaccine in Children Three Months to Five Years of Age Cellular and Humoral Components of Monocyte and Neutrophil Chemotaxis in Cord Blood Oral non-absorbed Antibiotics Prevent Infection in Acute non-lymphoblastic Leukemia Aspirin-induced Hepatotoxicity and Its Effect on Juvenile Rheumatoid Arthritis Prediction of Morbidity in Hemophilus Influenzae Meningitis Neurological Sequelae in Children Surviving Mechanical Ventilation in the Neonatal Period Developmental Effects of Prolonged Pregnancy and the Postmaturity Syndrome Long-term Outcome of Hemophilus Influenzae Meningitis Related to Antibiotic Treatment Recommendations for a National Policy on Poliomyelitis Vaccination Impaired Humoral Immunity in Treated Hodgkin's Disease Development of Immune Response during Typhoid Fever in Man In Vitro Susceptibility of Recently Isolated gram-negative Bacteria to Gentamicin, Sisomicin, Tobramycin, and Amikacin Studies of Urticaria and Acute Serum Sickness with the CI Precipitin Test Epidemic Measles in a Highly Vaccinated Population Congenital Chloride Diarrhea Acute Parotitis Associated with Influenza, Type A: Twelve Cases Urinary Tract Infection in high-risk Newborn Infants Maternal ABO Blood Group Type B: A Risk Factor in the Development of Neonatal Group B Streptococcal Disease

脑膜炎双球菌A羣被囊多醣类疫苗接种在3个月到5岁大小孩之临床效果脐带血内单核球及嗜中性球化学向性之细胞成分及体液成分口服不被吸收的抗生素可预防性急非淋巴球性白血症病人罹患感染阿斯匹灵引起之肝毒性及其对幼年性风湿样关节炎之影响流行感冒杆菌脑膜炎预后之预测新生儿时期接受人工呼吸器其日后神经系统上之后遗症过期妊娠及过度成熟徵候对发育之影响流行感冒杆菌脑膜炎之长期预后与抗生素治疗之关系对"小儿麻痹预防接种的国家政策"的建议 Hodgkin's disease治疗后体液免疫之缺损伤寒患者免疫反应的研究目前分离出来的革兰氏阴性菌在体外对Gentamicin,Sisomicin,Tobramycin和Amikacin之感受性荨麻疹和急性血清病CI沉淀素试验的研究在大多数接种人羣发生的麻疹流行先天性氯腹泻与influenza A型病毒有关的急性腮腺炎:12病例报告高危险性新生儿的尿道感染母亲血型B型:为新生儿发生B羣链球菌疾病之个危险因素

Firstly,the presence and location of AAT in amphioxus was studied by Westernblotting and immunohistochemical methods.The results first revealed that AATpresent in amphioxus,a cephalochordate.Also it was demonstrated that AATdistributed in cellular plasma in hepatic diverticulum,the pouch that protrudesforward as an outpocketing of the digestive tube and extends along the right side ofthe posterior part of the pharynx,which has long been considered to be the precursorof vertebrate liver.In vertebrate,AAT is primary synthesized in liver.

我们首先利用免疫组化和Western blotting方法,研究了AAT在文昌鱼的组织表达和定位,首次在头索动物文昌鱼中证明了AAT的存在,结果显示,AAT定位于文昌鱼肝盲囊的细胞浆内,从AAT在文昌鱼中的合成部位来看,在功能上文昌鱼的肝盲囊等同于脊椎动物肝脏,肝盲囊是在发育分化过程中消化道组织向右前方突出沿着咽后部向前扩展和延伸形成的一个囊袋状结构。

The result showed that during mitotic division, the Ser-10 phosphorylated histone H3 start from the prophase and vanished at telophase, remaining mainly in the pericentromeric regions at metaphase and anaphase. During the mitosis the microtubules take on regulated change pattern.

结果显示在小麦根尖细胞有丝分裂过程中Ser10磷酸化的组蛋白H3的出现和消失与染色体的凝集和解凝集的过程存在时空上的相关性,在有丝分裂的过程中这种蛋白在着经线粒上的定位有有助于染色体向两极移动。

The result showed that during mitotic division,the Ser-10 phosphorylated histone H3 start from the prophase and vanished at telophase,remaining mainly in the pericentromeric regions at metaphase.During the mitosis the microtubules take on regulated change pattern.

结果显示在小麦根尖细胞有丝分裂过程中Ser10磷酸化的组蛋白H3的出现和消失与染色体的凝集和解凝集的过程存在时空上的相关性,在有丝分裂的过程中这种蛋白在着经线粒上的定位有有助于染色体向两极移动。

Then the cultivated chondrocytes were embedded in fibrin glue fused on spongy bone, covered with priosteal flap; the complex was used to repair the femoral trochlea osteochondral defect which size is 3mm × 4mm × 4mm made in rabbit knee joint.

在A组的每只兔子的一侧膝关节股骨滑车部人为造成3mm×4mm的骨软骨缺损,骨刀切除软骨下骨到髓腔渗血为止(厚约4mm),压迫后FG止血;取髂骨骨块,并尽可能保留松质骨,取下的骨块用PBS反复清洗,以除去血细胞,将松质骨填充在骨缺损处,松质骨面朝向关节腔,高度与周边软骨下骨齐平,把骨膜片生发层朝向关节腔,用无创伤缝合线缝合在周边的软骨或滑膜组织上;向EP管中加入1/2悬液体积的FG主体胶溶液并混匀,再与主体胶等体积的催化剂溶液一同注射入骨膜与骨块密闭的腔隙中;同理处理另一侧膝关节。B组处理与A组相比只是不加入软骨细胞;C组造成骨软骨缺损,FG覆盖创面后单纯用骨膜修复缺损。

Clinical Efficiency of Meningococcus Group A Capsular Polysaccharide Vaccine in Children Three Months to Five Years of Age Cellular and Humoral Components of Monocyte and Neutrophil Chemotaxis in Cord Blood Oral non-absorbed Antibiotics Prevent Infection in Acute non-lymphoblastic Leukemia Aspirin-induced Hepatotoxicity and Its Effect on Juvenile Rheumatoid Arthritis Prediction of Morbidity in Hemophilus Influenzae Meningitis Neurological Sequelae in Children Surviving Mechanical Ventilation in the Neonatal Period Developmental Effects of Prolonged Pregnancy and the Postmaturity Syndrome Long-term Outcome of Hemophilus Influenzae Meningitis Related to Antibiotic Treatment Recommendations for a National Policy on Poliomyelitis Vaccination Impaired Humoral Immunity in Treated Hodgkin's Disease Development of Immune Response during Typhoid Fever in Man In Vitro Susceptibility of Recently Isolated gram-negative Bacteria to Gentamicin, Sisomicin, Tobramycin, and Amikacin Studies of Urticaria and Acute Serum Sickness with the CI Precipitin Test Epidemic Measles in a Highly Vaccinated Population Congenital Chloride Diarrhea Acute Parotitis Associated with Influenza, Type A: Twelve Cases Urinary Tract Infection in high-risk Newborn Infants Maternal ABO Blood Group Type B: A Risk Factor in the Development of Neonatal Group B Streptococcal Disease

脑膜炎双球菌A羣被囊多醣类疫苗接种在3个月到5岁大小孩之临床效果脐带血内单核球及嗜中性球化学向性之细胞成分及体液成分口服不被吸收的抗生素可预防性急非淋巴球性白血症病人罹患感染阿斯匹灵引起之肝毒性及其对幼年性风湿样关节炎之影响流行感冒杆菌脑膜炎预后之预测新生儿时期接受人工呼吸器其日后神经系统上之后遗症过期妊娠及过度成熟徵候对发育之影响流行感冒杆菌脑膜炎之长期预后与抗生素治疗之关系对&小儿麻痹预防接种的国家政策&的建议 Hodgkin's disease治疗后体液免疫之缺损伤寒患者免疫反应的研究目前分离出来的革兰氏阴性菌在体外对Gentamicin,Sisomicin,Tobramycin和Amikacin之感受性荨麻疹和急性血清病CI沉淀素试验的研究在大多数接种人羣发生的麻疹流行先天性氯腹泻与influenza A型病毒有关的急性腮腺炎:12病例报告高危险性新生儿的尿道感染母亲血型B型:为新生儿发生B羣链球菌疾病之个危险因素

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