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Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章:第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述;第二章研究了磷脂-桐酸脂质体的稳定性,通透能力及桐酸的聚合对这些性质的影响;磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体,〓的作用首先是使脂质体集聚然后使脂质体融合,并加速内包荧光物的释放;第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA,DDOL,研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响,聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性;第四章合成了两类氨基酸为极性基团的双亲分子,它们均可以在超声下形成稳定的脂质体结构;氨基酸基团可以在脂质体上进行缩聚反应,若聚合后脂质体表面仍有足够的亲水能力,则可得到稳定的多肽型脂质体;聚合后脂质体的相变温度降低,通透能力增加;第五章合成了四种亲水基团为单糖基的双亲分子GL-l,GL-2,GL-3, GL-4,研究了它们在水中的分散情况、集合体形态与分子结构的关系;在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高,阻止脂质体在低温放置时的集聚与融合;第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1,CL-2,CL-3;它们可以象胆固醇一样与磷脂混合形成稳定脂质体,胆甾环基团位于脂质体双分子层膜的中间;与胆固醇的作用相反,它们可以增加磷脂双分子层膜的流动性,降低混合脂质体的相变温度;三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关,比膜厚度短的分子影响最大。

Three basin prototype s are generated in the southeast of Junggar Basin: filling basin in the post-rift sequenceP_2-T_(2-3,foredeep basin in the post-rift sequenceT~~3__3-J_(1-2 and intracontinental foreland basin(J_3-E).

准噶尔盆地东南部发育了3套盆地原型,即P2—T2-3的后裂谷期充填盆地、T33—J1-2的裂谷后前渊盆地、J3—E的陆内前陆盆地的并列叠加作用;发育了3套主力生油岩系,即上二叠统芦草沟组、红雁池组和上三叠统黄山街组、郝家沟组及下、中侏罗统八道湾组、三工河组、西山窑组,并赋存于阜康凹陷、吉木萨尔凹陷、五彩湾凹陷、黄草湖凹陷之中,形成了多个供油中心。

We assumed that after the PACl〓 was dosed into water, its hydrolysis-aggregation-precipitation process combined the most popular"core-link"or hexameric ring scheme and the more recent model of polynuclear formation involving a typical specie of tridecameric,〓. The integrate pattern can nicely explained the phenomena.

另外,研究表明,PACl中预制的Alb形态和铝盐在混凝过程投加入水后形成的Alb形态在稳定性上有很大的区别,这无疑是由于它们的化学结构上的不同造成的,推测铝盐在投加入水后,其水解聚合过程按&六元环&模式〓和&核环&模式〓结合进行,这种综合模式可以很好的解释实验中的现象。

All right hind knees were made in this way: the auterior wall of suprapatellar bursae was scraped, the posterior wall of suprapatellar bursae and the infrapatellar fat pad were cut off.

手术切开右后膝关节,搜刮髌上囊前壁,切除大部分髌上囊后壁滑膜和髌下脂肪垫,术毕用长腿管形石膏固定右后肢膝关节于伸直位。

One player concealed a pen in his sock, and after he scored he took out the pen and autographed the ball. In a football game played in Dallas, Texas, a visiting team's player scored, then ran to the center of the field and celebrated on the Dallas logo, intending by this act to humiliate the Dallas team. In Lambeau Field, home of the Green Bay Packers, home team players who score take a "Lambeau leap" into the bleachers and are enveloped by the adoring crowds while the television cameras record the scene.

有个运动员在自己的袜子里藏了一枝笔,得分后拿出笔来就在球上签名;在得州达拉斯的一场橄榄球比赛中,客场队的一名球员得分后便跑到场中央在达拉斯的标志上面庆祝,想以这种方式羞辱达拉斯队;在绿湾搬运工队的大本营兰勃运动场,得了分的主场队员来了一个&兰勃跳&,跳到了一个露天座位上,接着就被崇拜的人群包围住了,而电视摄像机则记录下了这一幕。

One player concealed a pen in his sock,andafter he scored he took out the pen and autographed the ball. Inafootball game played in Dallas, Texas, a visiting teamsplayerscored, then ran to the center of the field and celebrated ontheDallas logo, intending by this act to humiliate the Dallas team.InLambeau Field, home of the Green Bay Packers, home team playerswhoscore take a Lambeau leap into the bleachers and are envelopedbythe adoring crowds while the television cameras record thescene.

有个运动员在自己的袜子里藏了一枝笔,得分后拿出笔来就在球上签名;在得州达拉斯的一场橄榄球比赛中,客场队的一名球员得分后便跑到场中央在达拉斯的标志上面庆祝,想以这种方式羞辱达拉斯队;在绿湾搬运工队的大本营兰勃运动场,得了分的主场队员来了一个&兰勃跳&,跳到了一个露天座位上,接着就被崇拜的人群包围住了,而电视摄像机则记录下了这一幕。

E. coli cells harboring the recombinant plasmid was cultured with Laria broth medium and induced with isopropyl β-D-thiogalactopyranoside and detected from supernatant and precipitate of culture lysates by using SDS-PAGE.

将重组菌培养并经IPTG诱导后用超声波裂解菌体,取上清和沉淀同时作SDS-PAGE电泳后显示,上清中没有热休克蛋白A的表达,在沉淀中有热休克蛋白A的表达。

In order to prove this point, Ratchet inferior lubricative solenoid valve core, manually put it on the oil lubrication, at which point it can be seen rising oil pressure drop, and exceeded the original value; successive pressing the lubricating oil pressure of the solenoid valve, can rise to 0.4 or even more, not by this confirmation oil pressure rise and oil pump surface temperature is too high because the machine cannot be automatically put oil lubrication.

为了证实这一不面,用起子底下润滑电磁阀的阀芯,手不静使其不收油润滑,此时可见油压回落后即上落并超功本来值;不断众次按不静润滑电磁阀后,油压竟可上落至0.4甚至以上,由此不否认油压落不矮和油泵暗地温度功矮的来因在于机械不克不及自不静举行不收油润滑所致。

Result]The MSCs attached to GDABM and grew along fibers in lozenge like or multiangular like manner Cells in GDABM group reached logarithm increasing period at the third day.

结果]8 h后MSCs在支架材料上呈球型黏附生长,4 d后MSCs在支架材料上呈菱形或多角型复层生长,包裹于大量细胞外基质内。

Induction of apoptosis by Etoposide was associated with upregulation of mRNAs for the BH3 only proteins Noxa, and to a lesser extent, Bim. In contrast, the expression levels of mRNAs for PUMA remained unchanged before and after treatment with Etoposide.

Noxa和PUMA主要受p53调节,细胞DNA损伤后通过p53可以上调Noxa和PUMA的表达[1]; Bim主要结合在微管动力蛋白上,受到细胞因子去除、Ca2+流出、紫外线照射、微管动摇和紫杉醇等刺激后可以转移到线粒体膜上[2],从而发挥促凋亡活性。

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And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47:5 法老对约瑟说,你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法,同时,采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。

Hey Big Raven, The individual lies dont matter anymore - its ALL a tissue of lies in support of...

嘿大乌鸦,个别谎言的事不要再-其所有的组织的谎言,在支持。