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During the postgenomics era the information about genomic sequence and gene functions provides a new foundation for evolutionary biology and ecology As the first whole-genome sequenced plant Arabidopsis thaliana and its wild relatives have played a critical role in understanding the evolution of genomics and speciation Both A halleri and A lyrata are closely related to the model species A thaliana A halleri ssp gemmifera occurs in northeastern China Japan and Taiwan; while its sister A halleri ssp halleri is mainly distributed in Europe Geographical barriers such as Tienshan Mountain Range isolate these intraspecific sisters Likewise A lyrata ssp kamchatica and ssp lyrata occur in East Asia and North America respectively Such distribution patterns seem to be consistent with allopartic speciation The comparison between ancestral and extant polymorphism by multilocus can be informative about the population genetics of speciation In this study we collected and analyzed DNA sequences of 98 genes from four wild relatives of A thaliana A halleri ssp gemmifera A halleri ssp halleri A lyrata ssp kamchatica and A lyrata ssp lyrata The ancestral states of these four species were compared to each other in terms of level of genetic variation However the ancestral species at the time of speciation were substantially more polymorphic than the extant geographical populations The observations are not fully compatible with speciation by strict allopatry At some species pairs parapatric speciation seems more reasonable in speciation of Arabidopsis The 98 gene sequences are also used for the congruence test between gene genealogy and species phylogeny Only 28 genes support the species phylogeny but there are 23 genes supports another major genealogy { lyrata} thaliana Based on the phylogenetic position change of A lyrata ssp kamchatica and Ks value for each species pair suggested the recent directional gene flow between A halleri ssp gemmifera and A lyrata ssp kamchatica

阿拉伯芥是第一个完成基因体定序的开花植物，其基因体资讯提供植物学研究的重要依据；在解析阿拉伯芥属物种的亲缘关系以及种化机制等重要的演化议题时，阿拉伯芥近缘的野生物种自然成了不可或缺的关键；跟阿拉伯芥近缘的物种包括A halleri及A lyrata，其中A halleri ssp gemmifera主要分布於中国东北、日本以及台湾，与近缘的A halleri ssp halleri其分布於欧洲隔著天山及大陆的障蔽，而A lyrata ssp kamchatica主要分布於东北亚及台湾，与分布於北美五大湖的A lyrata ssp lyrata被北极圈所分隔，这样的分布模式暗示异域种化的可能。藉由多基因分析比较祖先物种与现生物种遗传歧异度的相关可提供讯息探讨种化时期的族群遗传结构，本研究针对A halleri ssp gemmifera、A halleri ssp halleri及A lyrata ssp kamchatica、A lyrata ssp lyrata四个物种，两对互为亚种的姊妹群，以阿拉伯芥为外群进行研究，在四个物种完成98个同源基因的分子序列，利用套装软体MCMCcoal来估算祖先物种的遗传变异，亦估算现生物种的核苷酸歧异度，观察到？多物种配对中祖先物种遗传多型性大於现生物种DNA歧异度，显示异域种化模型并无法完全解释阿拉伯芥属物种的种化模式，在某些物种配对间邻域种化模式应比异域种化更为可能；在基因树与物种树的比较，98个基因片段的亲缘模式只有28个是与已知物种树一致的，有23个基因其树状图支持{ lyrata} thaliana的型式，藉由kamchatica位置的变化以及估算各物种配对间的平均同义置换率，推测在A halleri ssp gemmifera与A lyrata ssp kamchatica间具有近代的单方向基因交流。

At first it looked like a vast blue fort or Valhalla; but when they began to tuck the coarse meadow hay into the crevices, and this became covered with rime and icicles, it looked like a venerable moss-grown and hoary ruin, built of azure-tinted marble, the abode of Winter, that old man we see in the almanac ——his shanty, as if he had a design to estivate with us.

最初，我看这很像一个巨大的蓝色的堡垒，一个伐尔哈拉殿堂；可是他们开始把粗糙的草皮填塞到隙缝中间去了，于是上面有了白霜和冰柱，看起来像一个古色古香的，生满了苔藓的灰白的废墟，全部是用蓝色大理石构成的冬神的住所，像我们在历本上看到的画片一样，——他的陋室，好像他计划同我们一起度过夏季。

In terms of structural characteristics and geochemistry of the granites in conjunction with previous studies, we interpret that the garnet-bearing gneissic granite was formed during the collision between the Tianshuihai terrane and the Southern Kunlun terrane following the closure of a branch of the paleo-Tethyan ocean along the Mazha-Kangxiwa suture zone, the block hornblende-bearing granite was formed during post-orogenic extension. On the other hand, the granites of ca.

根据两个岩体的构造特征，结合前人的研究及地球化学特征，表明含石榴子石片麻状花岗岩形成于同碰撞造山时期，是甜水海地体与西昆仑南带晚古生代岛弧沿麻扎-康西瓦缝合带碰撞峰期的产物，代表了沿麻扎-康西瓦分布的古特提斯洋一个分支的闭合，而228 Ma块状含角闪石花岗岩形成于碰撞造山后的伸展背景。220～190 Ma持续发育的花岗岩是南昆仑地体拼合到北昆仑地体之后在其南部形成的新的深成岩浆弧带。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Such an interview, perhaps, would have been more terrible than even to meet him as she now did, with the hot, mid-day sun burning down upon her face, and lighting up its shame; with the scarlet token of infamy on her breast; with the sin-born infant in her arms; with a whole people, drawn forth as to a festival, staring at the features that should have been seen only in the quiet gleam of the fireside, in the happy shadow of a home, or beneath a matronly veil, at church.

个人。或许，在另外一种场合同他邂逅要益发可怕。如今呢，她那本来只该在壁炉旁恬静的柔光中b在家中幸福的暗处或在教堂的庄严气氛笼罩下才能看到的姿容，却在聚拢来的全镇人面前，被大家象看热闹似的死盯著：炎炎的午日烧灼著她的面孔，照亮了脸上的耻辱，她胸前佩著丑陋的鲜红标记，怀中抱著因罪孽而生下的婴儿。

Such an interview, perhaps, would have been more terrible than even to meet him as she now did, with the hot, mid-day sun burning down upon her face, lighting up its shame; with the scarlet token of infamy on her breast; with the sin-born infant in her arms; with a whole people, drawn forth as to a festival, staring at the features that should have been seen ssbbww.com in the quiet gleam of the fireside, in the happy shadow of a home, or beneath a matronly veil, at church.

或许，在另外一种场合同他邂逅要益发可怕。如今呢，她那本来只该在壁炉旁恬静的柔光中b在家中幸福的暗处或在教堂的庄严气氛笼罩下才能看到的姿容，却在聚拢来的全镇人面前，被大家象看热闹似的死盯着：炎炎的午日烧灼着她的面孔，照亮了脸上的耻辱，她胸前佩着丑陋的鲜红标记，怀中抱着因罪孽而生下的婴儿。

This paper demonstrated the impact on the environment today, an important factor is Education.

本文主要展示了当今影响环境的一个重要因素——教育。

Article 16 The power to interpret these Procedures shall remain with the Ministry of Agriculture and CAA.

第十六条本程序由农业部、国家认证认可监督管理委员会负责解释。