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In addition, our data indicated that the conformation of NR1 subunit homodimers was affected by the partner NR2 subunits during the formation of heteromeric receptor complexes, which might underlie the mechanism by which NR2 subunits modify NMDA receptor function. We also found that in the endoplasmic reticulum, even the whole extracellular N-terminal domain was truncated, the NR subunit could form homomers or heteromers with each other in HEK293 cells, which indicate that the NT is not the crucial element for the receptor assembly.

同时,通过推算FRmax,我们发现NR亚单位同二聚体的N端构象在形成功能性受体的前后是发生变化的,特别是对于NR1a亚单位,其同二聚体的N端构象会因与其配对的NR2亚单位的不同而发生不同的改变。

The photoresponsive properties of the azobenzene polymers are based on the photoinduced fast and reversible isomerization between the trans and cis isomers of azobenzene upon exposure to UV or visible light, which triggers significant changes in the physicochemical properties of polymer materials. Recent years have witnessed a rapidly increasing interest in azo-containing polymers due to their potential in various optical and optoelectronic applications such as optical data storage, liquid-crystal displays, molecular switches, nonlinear optical devices, photomechanical systems and so on.

偶氮分子在光照下能够发生可逆顺反异构,从而引起偶氮聚合物发生分子取向以及构象转变,使得偶氮聚合物具有优越的光学活性,同时偶氮聚合物结合了偶氮单体的光学活性和高分子材料优异的力学性能和加工性能,在光信息存储材料、非线性光学材料、液晶材料等领域都有重要的应用价值。

All the LOH on 〓 and 〓 was observed in invasive ductal carcino- ma, carcinoma simplex, medulary carcinoma and scirrhous carcino- ma, no deletions at these sites were observed in any invasive lobular carcinoma and others. These results imply an etiological difference.P53 gene is a hot point gene in the occurrence and development of breast, cancer. PCR-SSCP analysis was performed to detect P53 gene point mutation in the region between exon 5 and 8, 5 of 12 (41. 6%) stage I breast cancer patients contain mutation of P53, 3 of 5 patients were accompanied by 〓 deletion. These results suggested that point mutation and allelic loss of P53 gene are two vi- tal genetic events in earlier stage of breast tumorigenesis.

我们还发现,〓和〓位点LOH均分布在乳腺浸润性导管癌、单纯癌、髓样癌及硬癌中,在浸润性小叶癌和某些特殊类型乳腺癌中全部为LOH阴性,上述位点LOH可能与某些组织学类型乳腺癌的发生有关。P53基因是乳腺癌形成过程中的一个热点基因,本研究对12例Ⅰ期乳腺癌组织标本中P53基因热点区域第5、6、7、8外显子点突变进行了测定,发现41.6%(5/12)的病人有P53基因一个或多个点突变,其中3例同时伴有〓位点LOH,表明P53基因点突变和等位基因缺失是发生在乳腺癌形成早期的一个重要遗传学事件。

Nevertheless, in these aPproaches the contact intethee are charactered sboly edstiffeess K. and K.' which is not PerfeCt and rigorous in thc vitw of solidmechanics and rather rough for the description of the behavior of the iDtfores. Incollbet, taken as a contact Problem, the principal chatrs of the iDtCthees can bereflected: the cbntact inifore is of shear strength Which imPlies tha a genericpair of contact points on the inidse will displace coincidentally if the tangentialfbrce at this POint has not reahed the 1imit resistance, else, relative s1ide betwee the\ points will occur along the tangental direction.

本论文在对这两种方法进行认真的分析后,说明它们对不连续面的描述并不合理,也无法反映出不连续面的主要力学特性,同时指出,将带有不连续面的岩土工程问题作为接触问题计算更为合理,它可将不连续面受力变形的主要特点反映出来,即:(1)接触面具有相应的&抗剪强度&,即当接触面上某一点处的切向应力小于该点处的抵抗强度时,点对共同变形;达到强度时,则沿切向发生相对滑动;(2)在整个变形过程中,发生接触的变形体不能相互侵入。

Based on two kinds of control strategies of VSR under unbalanced grid condition,the introduction of a new VSR control strategy featuring undamped -oscillation that simplifies the controller structure and effectively improves VSR"s performance under unbalanced grid condition.· A systematic description of the state switching in trilogic PWM signal generation of three-phase CSR by using the conversion between bilogic and trilogic switching functions.· Referenced to the CSR"s trilogic PWM signal generation, an approach to achieve low-stress natural commutation of switching devices by reshuffling the vector composition sequence, resulting reduced switching loss.

在研究了两类电网不平衡时的VSR控制策略基础上,提出了一种新型的基于无阻尼振荡控制器的VSR不平衡控制策略,在简化控制结构的同时,有效地改善了电网不平衡时的VSR控制性能;·通过二、三值逻辑开关函数间的转换,系统地描述了三相CSR三值逻辑PWM信号发生中的状态切换;·结合三相CSR三值逻辑PWM信号发生规律,提出了通过调整矢量合成顺序而使功率管获得自然换相的低电压应力SVPWM控制,从而有效地降低了功率管的开关损耗。

Referenced to the CSR's trilogic PWM signal generation, an approach to achieve lowstress natural commutation of switching devices by reshuffling the vector composition sequence, resulting reduced switching loss. With the background of and well instanced by the Xinjiang Autonomous Region's Key SciTech Project"Solar Photovoltaic grid-connected inverter", the dissertation work implemented the new approach of a grid-connected PV inverter that was of single-phase VSR topology and with MPPT .

在研究了两类电网不平衡时的VSR控制策略基础上,提出了一种新型的基于无阻尼振荡控制器的VSR不平衡控制策略,在简化控制结构的同时,有效地改善了电网不平衡时的VSR控制性能;通过二、三值逻辑开关函数间的转换,系统地描述了三相CSR三值逻辑PWM信号发生中的状态切换;结合三相CSR三值逻辑PWM信号发生规律,提出了通过调整矢量合成顺序而使功率管获得自然换相的低电压应力SVPWM控制,从而有效地降低了功率管的开关损耗。

It indicates that the delocalizing interaction existed between the big pi bond of porphyrin and surface of TiO2 with 10 nm in diameter.

卟啉与粒径为10 nm的TiO2作用后,能级发生了简并,同时带隙发生了红移。

And we also research the impact of methylating on hydrogen bond and stacked bond in base pairs under considering water molecules.

研究结果表明,烷基化之所以能造成碱基错配是它可使碱基的质子迁移或烯醇互变现象容易发生,改变原有原子的电荷分布或配对模式,同时碱基自身的互变异构体会跟烷基作用,致使互变异构体能够稳定存在,影响正常碱基配对,引起碱基诱变,造成生理疾病的发生。

The strength wreaks havoc the society plays the attack, to stop the role which the evil influence wreaks havoc and to have the purification social convention the function; The article also mentions me seeks help after the God to persecute me few human and the place related congeals is forms persecutes me the human to have the death and the disaster, this is with the fact explained that sought help to the God has received the unprincipled person worked as disaster's consequence, was also the significant use way feasible fact which went to straighten up evilly proved; Simultaneously in I seek help for nearly ten years after the government not to be able to obtain the help instead encounters the greatly flagrant persecution me seeks help after the God to have the big earthquake and so on significant disaster, I thought that this is the God to the human Related organization's penalty and the warning, is to has difficultly to seek help does not help instead to help the evil influence to persecute the present government which the human some governments or the organization note here said is some evil

力肆虐的社会起到打击、制止邪恶势力肆虐的作用及起到净化社会风气的作用;文章还提及到我向神灵求助后迫害我的个别人及地方相关凝是形成迫害我的人发生死亡及灾祸,这是用事实说明向神灵们求助收到了坏人当灾的后果,也是去邪扶正的重大使用途径可行性事实证明;同时在我向政府求助近十年得不到帮助反遭到更大更明目张胆的迫害后我向神灵求助后发生了大地震等重大灾难,我认为这是神灵对人类有关组织的惩罚和警告,是对有难求助不帮反助邪恶势力迫害人的一些政府或组织注这里所说的现政府是一些被邪

Syringolin Reprograms Wheat to Undergo Hypersensitive Cell Death in a Compatible Interaction with Powdery Mildew. The Plant Cell,13:153-161[11]Guo Yongfeng,1995. New Method of Identifying Resistance to Brown Spot of Tobacco-Method of Identifying Toxin-Resistance.

根据Alvarez等的结果,连接HCD与SAR的分子是HCD过程中所产生的活性氧[13],我们在研究中也发现,赤星菌毒素不仅可以诱导烟草发生HCD,同时还可诱导烟草发生明显的H2O2积累。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。