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Based on the fact that aminoacyl-tRNA synthetase is a bona fide drug target for several microorganisms, including bacteria and fungi, it is plausible that it may also be effective target of Trypanosoma. In this report, the Trypanosoma brucei Leucyl-tRNA synthetase was cloned , expressed and purified to develop an in vitro enzymatic assay system.

根据亮氨酰tRNA合成酶在微生物中可作为药物靶点的事实,在新型抗锥虫药物筛选中,通过对锥虫的亮氨酰tRNA合成酶的克隆、表达和纯化,以及该酶活性测定的优化,建立了该酶抑制物的筛选系统。

Mesoporous zincum sulfide is synthesized by gentle wet chemosynthesis method, with DDA as templates and Zinc acetate and TAA as precursors. The effect to the synthesis of the ratio of reactive components, the volume of pH, reactive time and reactive temperature has been dicussed systematically, and structures of the as-synthesized samples have been characterized by X-ray diffraction, N2 adsorption-desorption, scanning electron microscopy, Fourier transform-infrared spectra, UV-vis diffuse reflectance spectroscopy, transmission electron microscopy.

以十二胺为模板,醋酸锌及硫代乙酰胺为前驱体,温和湿化学法合成了硫化锌无序介孔结构,系统研究了反应物配比、pH值、反应温度、反应时间对材料合成的影响,运用X射线衍射、N2吸附-脱附、扫描电镜、红外光谱、紫外-可见吸收光谱、透射电镜等分析手段对介孔材料的结构进行了详细的表征。

It was found that zymosterol in S. cerevisiae GL7 cells and cycloartenol in P. wickerhamii cells were accumulated when treated with solasodine. Zymosterol and cycloartenol are respective substrates of sterol 24Cmethyltransferase in S. cerevisiae GL7 and P. wickerhamii, hence we deduced that sterol C-24-methyltransferase is the main target of solasodine.

根据澳洲茄胺对S.cerevisiae GL7和P.wickerhamii的甾醇生物合成途径的抑制结果均积累24位甾醇甲基化转移酶的底物,分别是zymosterol和cycloartenol,初步阐明了澳洲茄胺的主要作用靶点是24位甾醇甲基化转移酶,而其它几种抗真菌生药活性成分不影响甾醇的生物合成途径。

Amino acids chelated iron are usually synthesized in solution,it takes a long time and has liquid wastes.

氨基酸亚铁螯合物的合成普遍采用液相技术,合成时间长,存在废液污染。

This part includes chapter 5, 6, 7, 8, and chapter 9. In chapter 5, we synthesized four Ruthenium chelates, which can be used as ECL reagents. We also investigated their fluorescent properties as well as their electrochemical and ECL properties.

在第5章中,我们合成了四种带有标记基团的钌配合物电化学发光试剂,并对所合成的四种化合物的荧光性质、电化学性质及电化学发光性质等进行了初步探讨。

The main reason of complex with greater nonlinear refractive index is that the complex has larger conjugated delocalized system and there are electrons shifting between ligand and metal atom.

选择具有π键的配体与金属离子合成为配合物,使其非线性效应明显增强,这对合成性能更好的非线性材料有一定的参考价值。

Developing new synthetic route and synthesizing new type of miktoarm stars will be of great significance.

研究新的合成路线,对合成新型的杂臂共聚物具有重要意义。

The types,structures of substrates and reaction mediums for the enzymatic synthetic polyphenol resin was surveyed and the manufacturing method,product structure and their performances of the polyphonel resin and aldehyde resin were compared.

概述了酶催化合成聚酚树脂用酶的种类、底物的结构、反应介质;比较了该树脂和传统酚醛树脂的生产、结构及性能特点;指出了其不仅具有良好的耐热性能,可作传统酚醛树脂的替代品,而且具有导电、发光等功能,在光电材料方面显示了极强的应用潜力,但降低HRP催化合成聚酚树脂的成本是其实现工业化亟待解决的问题。

Suzuki cross-coupling of aryl bromides with arylboronic acid is one of effective methods to form biphenyl derivatives in organic synthesis.

在有机合成中,Suzuki交叉偶联反应是制备联苯类化合物最重要的方法之一,本论文设计并合成了二个P⌒O系列、一个P⌒N系列双齿配位的钯配合物。

The preparation of the low expansion graphite intercalated compound and the selection or development of the catalyser were involved in the research.

在国内外首次研究成功以无硫低倍膨胀石墨层间物为原料合成氟化膨胀石墨和低温催化合成氟化石墨新技术。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。