合成物

It was known that pyridine and Triton-x100 had a bad effect on the cell growth and lycopene production were studied. The results indicated that pyridine and triton-x100 inhibited cell growth and lycopene synthesis;β-ionone increased cell growth and lycopene synthesis when the concentration was 0.05 ml/L, but when the concentration became higher, there would be a decrease on the lycopene output; span-20 increased cell growth and lycopene synthesis effectively when the concentration reached 2.0ml/L, and the lycopene yield became 2.4×10~(-2) mg/L which was 3-fold than control.

研究了培养基中加入不同浓度的小分子效应物吡啶、Triton-x100、Span-20、β-紫罗酮、异烟肼对番茄红素产量的提高作用，结果显示培养基中加入很低浓度的吡啶(0.1ml／L)就会对菌体产生很强的毒害作用；triton-x100对类胡萝卜素的合成也有很强的抑制作用，试验的浓度为0.2ml／L到5ml／L，结果发现它对菌体的生长和番茄红素的合成都有抑制作用；β-紫罗酮在浓度为0.05ml／L时有很小的促进作用，而浓度升高就有了比较强的抑制效果；span-20在液体培养基中的加量为2.0ml／L时，对番茄红素的合成有很强的促进效果，产量达到了2.4×10~(-2)mg／L，比原始菌株产量提高了2倍，而浓度进一步增大就产生了很强的抑制效果。

We discussed the syntheses of two different types of plant alkaloids in this thesis. In part A, we aimed at total syntheses in two kinds of aporphine alkaloids, lirioferine and boldine. In part B, we developed a tactic about radical cyclization in polyhydroxylated piperidine synthesis.

中文摘要本篇论文中探讨了两种不同种类植物碱的合成，在A部分中，我们针对阿朴吩类天然物中的鹅掌楸啡碱与波儿丁碱做了各自的全合成研究；在B部分中，我们发展了一种自由基环化策略运用在含多羟的哌啶类化合物之合成上。

Secondly,the synthesis of SIPE and the reaction conditions such as catalyst,anti-ether agent,temperature and water are researched to control the generation of diethylene glycol and the self-polymerization of SIPM by controlling the total quantum of distillate and the temperature of distillation column and reaction and the reliable synthetic conditions of SIPE are obtained.

其次，在此基础上，研究了三单体的中间体SIPE的合成工艺，研究了催化剂、抑醚剂、反应温度及水分等对合成反应的影响，同时提出了控制馏出物总量、控制分馏柱温度和控制反应温度等措施来控制二甘醇生成反应和SIPM自聚等副反应，得到了可靠的SIPE合成工艺。

Reaction of 5'-O-p-methoxytrityl-thymidine with 1, 1'-carbonyl-diimidazole gave the 3'-O-carbonylimidazolide, which was condensed in high yield with 3'-O-protected thymidine to give a dithymidine carbonate. In the same way, we obtained the protected trithymidine dicarbonate. After deprotection, we obtained quantatively the trithymidine dicarbonate.By the same stratagy, we completed the synthesis of dithymidine sulfite.It was shown that allyl can be used as a good protection group for hydroxyl of ribose in the synthesis of oligonucleotides consisting in some unstable nucleotide analogues.

我们在第一部分工作的基础上，以烯丙基作为3'-OH的保护基合成了保护的三胸苷碳酸酯以及二胸苷亚硫酸酯，用我们所得的脱保护条件进行了脱保护研究，得到了三胸苷碳酸酯以及二胸苷亚硫酸酯，并研究了它们合成中的一些化学问题，结果表明：烯丙基能很好地运用于这两类寡核苷酸类似物的合成中，其脱保护条件为中性，不会影响碳酸酯键及亚硫酸酯键。

The formation of charge transfer complex was studied in the first part. The second part includes the synthesis and characterization of the acrylated unsaturated polyester and the kinetic studies on the Ar-UPE/ triethylene divinyl ether (DVE-3) photocuring system, the rheology and properties of film after photocuring. The third part includes the synthesis and characterization of the urethane modified unsaturated polyester and the kinetic studies on the PU-UPE/DVE-3 photocuring system, the rheology and properties of film after photocuring. The fourth part includes the synthesis and characterization of the vinyl ether end capped polyurethane and the kinetic studies on the VE-PU/DVE3 photocuring system, the rheology and properties of film after photocuring.

整个研究工作分为四个部分：一是电荷转移复合物的研究；二是丙烯酰氧基化不饱和聚酯的合成，表征，Ar-UPE/二缩乙二醇二乙烯基醚（DVE-3）体系光固化动力学研究以及Ar-UPE/DVE-3体系流变性能和光固化后涂膜综合性能的研究；三是氨酯改性的不饱和聚酯的合成，表征，PU-UPE/DVE-3体系光固化动力学研究以及该体系光固化后涂膜综合性能的研究；四是乙烯基醚封端的聚氨酯的合成，表征，VE-PU/马来酸二甲酯体系光固化动力学研究以及VE-PU/DMA体系流变性能和光固化后涂膜综合性能的研究。

The mechanism in which trehalose is produced from dextrin or starch hydrolyzate by endocellular enzymes of bacterium D-97 can be elucidated by high performance liquid chromatography with differential refraction detection basically, including the effect of the different carbon sources on the endocellular trehalose-producing enzymes in bacterium D-97 and the possibility or ability of the endocellular enzymes to produce trehalose using maltooligosaccharides of different chain lengths.

通过高效液相色谱/示差折光检测系统分析可获得细菌D-97利用糊精或淀粉水解物合成海藻糖的基本生物学信息，包括微生物培养碳源对细菌D-97胞内海藻糖合成酶系的影响以及该酶系利用不同种类或不同分子链长度的麦芽寡糖合成海藻糖的能力及作用过程。

Most of the studies have demonstr ated that glutamine serves metabolic roles for macrophage.By glutamiolysis pat hway,glutamine provides ATP for the cellular metabolism,intermediates for the biosyn thesis of parine,pyrimidine and nuclecotides,and nitrogen for the formation of glucosamine,GTP and NAD+.

研究表明谷氨酰胺是单核巨噬细胞主要的代谢底物，通过谷氨酰胺酵解途径，为细胞代谢提供能量；为细胞合成DNA和mRNA提供嘌呤、嘧啶、核苷酸生物合成前体；提供氨基葡萄糖，GTP和NAD+合成的氮前体。

Owing to the versatile application of pentaerythritol derivatives to organic synthesis, a lot of organic synthesis methods are able to be used in preparation of the new kind of glycoconjugate.

同时， 由于季戊四醇衍生物在有机合成领域应用广泛，很多有机合成方法都可以应用到这类糖缀合物的合成中。

In this research, two novel compounds in which alkylenedithiomethylene Malonic acid act as the main coordination agents and the compounds containing N atom (such as pyridine, Phenanthroline Ethanediamine and 4,4'-Bipyridinyl) act as the associating coordination agents have been synthesized by the means of solution and solid-liquid diffusing reactions. 9 coordination complexes and polymers have been designed and synthesized in which the transition metals Cu and Zn acted as the centre ions. These compounds have been characterized by X-ray single crystal diffraction analysis, and some properties of them have been tested and analyzed.

本论文设计合成了两种结构新颖的含有二硫缩烯酮结构的丙二酸类化合物，以此为主要配体，以含氮化合物(吡啶、邻菲罗啉、乙二胺和4，4'-联吡啶)为辅助配体，采用常规溶液合成和固-液相扩散等方法，设计合成了9个过渡金属Cu和Zn离子配合物和配位聚合物，采用单晶X-射线衍射等技术对晶体结构表征，并对其部分性质进行了测试和分析。

Peptides are traditionally synthesized in liquid phase, such methods are DCC, mixed anhydrides, acyl chloride and azide etc., which provide more choices for peptides synthesis.

传统的肽类合成多采用液相化学合成，常用的包括碳二亚胺法，混合酸酐法、酰氯法、叠氮物法等等，为多肽的合成提供了多种选择。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失