合成物

The preparation method comprises monomer synthesis and polymer synthesis. The polymer synthesis is that cyclopentadienyl sodium monomer is added into metallic cobalt complex-triphenyl phosphorus cobalt chloride under strict oxygen-free and water-free conditions, and then double inner alkyne or outer alkyne conjugate monomer is added in, and after reaction, the precipitation, filtering, abstersion and vacuum-drying are carried out, the large molecules polymer containing cyclopentadienyl cobaltocenium organometallic cobalt is obtained.

制备方法，包括单体合成和聚合物的合成，聚合物的合成是在严格无氧无水条件下，在金属钴配合物三-三苯基磷氯化钴，加入环戊二烯钠单体，随后加入双内炔或双外炔共轭单体，反应后沉淀，过滤，洗涤，真空干燥，得到含环戊二烯茂钴有机金属钴的大分子聚合物。

The model was used to fit the release profiles of the above three different actives, and the diffusion coefficient and dissolution rate constant were obtained. Based on the modeling study, the relationship of porous microspheres structure, actives performances and release behavior was found, hence a theoretical basis was provided to optimize the microsphere synthesis and desired actives release profile.

采用提出的模型对三种活性物的体外释放实验数据进行拟合，求得不同活性物的有效扩散系数和溶解速率常数，揭示了微球结构、活性物性质和释放性能关系的一些基本规律，为指导微球合成、改善和控制活性物的释放性能提供了基础。

After that, we introduced a new approach to synthesis of valiolamine, by a series of reaction to the carbon-carbon double bond from the substrate of valienamine, including epoxidation, hydrogenolysis and so on, and obtained the aim product finally.

在完成上述合成路线后，本文通过提出了一条全新的合成伏格列波糖重要中间体valiolamine的路线，即采用对底物valienamine中的碳-碳双键进行环氧化、氢解等一系列反应，成功地制备出所需的中间体，研究全新的合成伏格列波糖的路线，研究结果证实：该新路线已经被打通。

During these years (1997-2000) in the research area of annonaceous acetogenins 5 natural products and a number of chiral-pure analogs of annonaceous acetogenins have been synthesized using sugars as the starting materials. Their high activity and selectivity against cell line of colon tumor and a relationship between activity and configuration have been found too. In the respect of inhibitor of sialidase two new methodologies for the synthesis of chiral-pure 3-deoxy-ulosonic acid using hetero-Diels-Alder reaction or asymmetric propargylation as the key reaction were developed. On the topic of anti-leukemia marine natural product clavulactone a synthetic method based on the free radical cyclization and starting from sugar has been developed. In other title of PKC inhibited agent sphingosine a new synthetic route with SN2' as the key reaction has also been disclosed.

项目期间（1997-2000）在番荔枝内酯方面从糖出发合成了五个天然产物和一批手性纯的类似物，它们对肠癌细胞有很高的活性和选择性，并与构型有关；在唾液酸酶抑制剂方面发展了二类全新手性纯高碳糖的合成方法－杂原子D－A反应或丙炔基不对称加成为关键的反应；抗白血病海洋天然产物群柱虫内酯方面研究了由糖出发和自由基环化反应的合成方法；对PKC 起抑制作用的鞘氨醇方面也开创了新的合成途径－由糖出发并以SN2'反应为关键反应。

The copper atom is in a planar coordination site of [N_2O_2] and it devites from the mean plane by only 0.80 pm. Byπ-πstacking interactions, a alabastrine structure was obtained.(2)Schiff-base complex [Cu(H_2O)]·H_2O, where H3GS is the 3-carboxyl -salicylidene glycine, was synthesized and characterized by elemental analysis, IR spectra and single-crystal analysis. The crystal belongs to monoclinic system, space group P2(1)/c, a=848.46(3)pm, b=681.54(3)pm, c=1967.16(8)pm,β=95.8210(10)°, Z=4, R_1=0.0279, wR_2=0.0724. The copper atom is in a square-pyramidal field with the base

结果表明该晶系属单斜晶系，空间群P2(1)/c，晶胞参数：a=848.46(3)pm，b=681.54(3)pm，c=1967.16(8)pm，α=90°，β=95.8210(10)°，γ=90°，Z=4，R_1=0.0279，wR_2=0.0724，Cu原子位于轻微变形的四方锥场底心，底面被氮原子、酚氧原子、甘氨酸羧基的一个氧原子和一个水分子氧原子占据，而甘氨酸羧基的另一个氧原子占据相邻分子的锥顶，因而形成一维链状结构；合成了单核双聚配合物Na_2[Cu_2_2]·2H_2O ，铜三核配合物Cu_3_2·5H_2O和铜锌异三核配合物ZnCu_2_2·5H_2O，并用元素分析，IR光谱，电子光谱和磁化率测定对配合物的组

They are derived from the condensation of salicylaldehyde with naphthalidine, 2-cyano-4-chloroaniline, o-Toluidine, N-aminoethylmorpholine, benylamine, butylamine, cyclopentylamine and 3-carboxysalicylidene with N-aminoethylmorpholine, benylamine, 2-hydroxyaminoethylamine, ethylenediamine, respectively.

得到了HL1、HL2和HL3配体的单晶；培养出了HL3～HL6、H2L11的Cu配合物，HL7～H2L11的Co配合物和H2L11的Ni配合物的单晶。此外，以5-溴水杨酸(5-bsa)、2-氨基苯甲酸(2-aba)、六次甲基四胺等为原料，合成了3种过渡金属Ag配合物，并培养出了其单晶。

Sn with the content of 0.004% in the lithosphere is almost in presence of cassiterite and little in presence of Sn-contained sulfide. Since 1980s, the anticancer active study on organic complex compounds has attracted considerable attentions, it becomes another hot issue after the study on Pt. When time up to the year 1989, the anticancer active measurement of more than 2000 kinds of Sn-contained complex compounds have been carried out by Cancer Academy, U.S, with the results showing half of these Sn-contained complex compounds posses antileucocythemia(P388) activity. Thereafter, Sn-contained complex compounds synthesized by hydrothermal reaction also become a hot issue people focus on.

Sn在地壳中的含量为0.004%，几乎都以锡石的形式存在，此外还有极少量的Sn的硫化物。20世纪80年代以来，人们对Sn有机配合物抗癌活性的研究产生了浓厚兴趣，成为继顺铂之后又一活跃的研究热点，到1989年，美国国家癌症研究所对2000多种Sn的配合物进行了抗癌活性测定，结果表明，50%的配合物具有抗P388白血病活性，故水热溶剂热合成锡的配合物也成为人们的研究热点。

Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章：第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述；第二章研究了磷脂-桐酸脂质体的稳定性，通透能力及桐酸的聚合对这些性质的影响；磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体，〓的作用首先是使脂质体集聚然后使脂质体融合，并加速内包荧光物的释放；第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA，DDOL，研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响，聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性；第四章合成了两类氨基酸为极性基团的双亲分子，它们均可以在超声下形成稳定的脂质体结构；氨基酸基团可以在脂质体上进行缩聚反应，若聚合后脂质体表面仍有足够的亲水能力，则可得到稳定的多肽型脂质体；聚合后脂质体的相变温度降低，通透能力增加；第五章合成了四种亲水基团为单糖基的双亲分子GL-l，GL-2，GL-3， GL-4，研究了它们在水中的分散情况、集合体形态与分子结构的关系；在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高，阻止脂质体在低温放置时的集聚与融合；第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1，CL-2，CL-3；它们可以象胆固醇一样与磷脂混合形成稳定脂质体，胆甾环基团位于脂质体双分子层膜的中间；与胆固醇的作用相反，它们可以增加磷脂双分子层膜的流动性，降低混合脂质体的相变温度；三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关，比膜厚度短的分子影响最大。

Two novel tridentate polypyridyl mixed-ligand cobalt [Co (H2Bzimpy)(superscript 3+)] and ruthenium complexes were synthesized and characterized via elemental analysis and (superscript 1)H NMR. The crystal structure of complex B was determined. The interactions between the complexes and calf thymus DNA were investigated with absorption and fluorescence spectroscopys. Photoactivated cleavage of pBR322DNA by the synthesized complexes were studied.

合成了两种新型三齿多吡啶钴[Co(H2Bzimpy)](上标 3+)和钌混配配合物，用元素分析和1HNMR等对其结构进行了表征，测定了配合物B的晶体结构用电子吸收光谱和荧光光谱等方法研究了配合物与小牛胸腺DNA的相互作用以及配合物对pBR322DNA的断裂作用。

On the way, By giving the example as the names of the thing (such as silk silks etc.) with color and the basic colorific phrase associated with it, this text demonstrated a fact that the basic colorific phrases were evolved from the names of the thing that include the color, under the function of the come from the method that is borrowing the thing assumes the color, and expatiated the condition of the basic colorific phrase in Chinese language. Take the synthesize colorific phrase implied compliment or dispraiser as an example, explained the imagism of Chinese thought method how to influence the synthesize the colorific phrase, and do it by taking the food, metals and nature scenery makes the ratio at other Chinese thought method that is take shape to analogy as too. It expatiated the influence that the Han ethnologic culture result in the acceptation of the colorific phrase, pass on analyze the diverse the diverse metaphor meanings of colorific phrase and the opposite phenomenon of acceptation among them of, and the colorific etyma metaphor of "yellow","vermilion","purple","blue","green" and "white", under the premise that distinct the different between themetaphor meanings of colorific phrase and colorific etyma metaphor.

由此本文通过例举有色彩含义的事物专有名称及相应的基本色彩词，分析了基本色彩词是在&借物呈色&思维方式的影响下，由有色彩含义的事物专有名称演变而来的事实，并阐述了汉语基本色彩词的状况；以含有褒扬、贬抑语义的合成色彩词为例说明了汉民族&意向性&思维方式对合成色彩词的影响，以取食物、金属、自然界景物作比的合成色彩词为例说明了汉民族&取象类比&思维方式对合成色彩词的影响；在区分色彩词隐喻意义与色彩语素隐喻意义的基础上，通过分析色彩词的多元隐喻意义及其中的语义对立现象，并分析&黄&、&朱&、&紫&、&青&、&绿&、&白&等色彩语素的隐喻意义，阐述了汉民族文化对色彩词语义的影响。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失