合成因子

In the feedback regulation system of choles-terol metabolism, SCAP together with membrane-bound transcription factors - sterol regulatory element-binding proteins control transcription of the genes encoding enzymes of choles-terol and fatty acid biosynthesis.

在胆固醇代谢的反馈调节系统中，SCAP与膜结合转录因子胆固醇调节元件结合蛋白(sterol regulatory element binding proteins；SREBPs)等调节因子，共同控制一系列酶编码基因的转录过程，包括胆固醇和脂肪酸生物合成过程中所需的酶。

In general, cytokines are induced transiently upon cell activation.

细胞因子是由机体细胞合成并分泌的小分子多肽类因子，它们参与多种细胞的增殖、分化，在免疫和炎症反应中发挥重要作用。

Methodological design, synthesis is aimed at anoxic and revulsive factor - the nucleotide of few of particularity short cable length of 1 α is acerbity, compose builds anoxic and revulsive factor - of ShR-NA of 1 α particularity recombine plasmid, stability turns catch; of cell of colonic cancer SW 480 to use chloridize cobalt preparation is anoxic and revulsive education radical, imitate tumour is anoxic condition.

方法设计、合成针对缺氧诱导因子-1α的特异性短链寡核苷酸，构建缺氧诱导因子-1α特异性shR-NA的重组质粒，稳定转染结肠癌SW 480细胞；采用氯化钴制备缺氧诱导培养基，模拟肿瘤缺氧状态。

It has been found that ectogenic GDNF has nervous protective effec,but ectogenic GDNF cannot enter blood brain barrier.

传统观点认为，星形胶质细胞是神经系统的支持细胞，构成神经组织的网架而起支持作用，与神经元的解剖位置关系紧密，参与中枢神经系统的免疫反应，参与构成血脑屏障，目前研究发现，脑缺血时星形胶质细胞异常活跃，通过合成多种蛋白质、细胞因子和神经营养因子等对神经元起保护作用，对缺血性脑损伤的发展和转归具有重要意义。

Nineteen spots were changed significantly after FA treatment.Thirteen proteins were identified by peptide mass fingerprinting or peptide sequence analysis,including putative nucleoside diphosphate kinase,elongation factor 1-gamma,triosephosphate isomerase,60S acidic ribosomal protein P0,heat shock protein 75 kDa,similar to heat shock 70kD protein binding protein,annexin I,hypothetical protein FLJ34423,microtubule-actin crosslinking factor 1,lamin B2,ATP synthase alpha chain,mitochondrial precursor,proteasome subunit alpha type 6.These identified proteins involved in energy metabolism,translation and RNA processing,protein folding,redox regulation,cell structure and cell signaling.

双向凝胶电泳结果显示，甲醛刺激后19个蛋白斑点发生变化，肽指纹图谱及肽序列标签鉴定了其中13个蛋白斑点，已鉴定的蛋白包括二磷酸核苷酸激酶、延长因子1-γ，磷酸丙糖异构酶、60S酸性核糖体蛋白P0、75kDa热休克蛋白、70kD热休克蛋白样结合蛋白、钙依靠磷脂结合蛋白I、假想蛋白FLJ34423、微管-肌动蛋白交叉连接因子1、核纤层蛋白B2、ATP合成酶α链、蛋白酶体α亚基6，这些蛋白功能涉及转录调节、蛋白折叠、信号传导、能量代谢、细胞骨架等各个方面。

Thirteen proteins were identified by peptide mass fingerprinting or peptide sequence analysis,including putative nucleoside diphosphate kinase,elongation factor 1-gamma,triosephosphate isomerase,60S acidic ribosomal protein P0,heat shock protein 75 kDa,similar to heat shock 70kD protein binding protein,annexin I,hypothetical protein FLJ34423,microtubule-actin crosslinking factor 1,lamin B2,ATP synthase alpha chain,mitochondrial precursor,proteasome subunit alpha type 6.These identified proteins involved in energy metabolism,translation and RNA processing,protein folding,redox regulation,cell structure and cell signaling.

双向凝胶电泳结果显示，甲醛刺激后19个蛋白斑点发生变化，肽指纹图谱及肽序列标签鉴定了其中13个蛋白斑点，已鉴定的蛋白包括二磷酸核苷酸激酶、延长因子1-γ，磷酸丙糖异构酶、60S酸性核糖体蛋白P0、75kDa热休克蛋白、70kD热休克蛋白样结合蛋白、钙依赖磷脂结合蛋白I、假想蛋白FLJ34423、微管-肌动蛋白交叉连接因子1、核纤层蛋白B2、ATP合成酶α链、蛋白酶体α亚基6，这些蛋白功能涉及转录调节、蛋白折叠、信号传导、能量代谢、细胞骨架等各个方面。

The results showed that TNF-α effectively inhibited preadipocyte proliferation stimulated by insulin and decreased lipogenesis through inhibiting stimulation of insulin on transcriptional expressions of lipogenic genes such as acetyl-CoA carboxylase α(ACC1), fatty acid synthase, sterol regulatory element binding protein-1c in adipocytes, suggesting that TNF-α is a effective inhibitor of adipogenesis in adipose tissue.

结果表明，TNF-α可有效抑制胰岛素对原代培养大鼠前体脂肪细胞增殖的促进作用，并通过抑制胰岛素对转录因子SREBP-1c和脂肪酸合酶FAS及ACC1基因转录表达的促进作用，减少脂肪酸的生物合成，抑制成熟脂肪细胞的脂肪生成，证明TNF-α是动物脂肪形成的有效抑制因子。

To localize the functional positions of biomolecules in ciliates cell, we constructed a macronuclear artificial chromosome containing a gene encoding red fluorescence protein based on the structural characteristics of ciliates chromosome.

为了能够有效地分析生物大分子在该细胞中的功能作用位点，本研究根据该生物染色体结构的特征，构建了含有红色荧光蛋白的大核人工染色体EoMAC_R，并与之前构建的含绿色荧光的大核染色体EoMAC_G一起，对蛋白质合成终止有关的3个重要因子核糖体大亚基蛋白L11、多肽链释放因子eRF1和eRF3在八肋游仆虫细胞中进行了荧光共定位分析。

Nerve growth factor is the fist found cellar factor that regulates cell growth, and it plays a very important role at the phrase of nerve development、neuraxon growth、 neurotransmitter synthesization and cell apoptosis and so on.

神经生长因子是最早发现的细胞生长调节因子，在神经元的发育、轴突的生长、递质的合成及细胞的凋亡等阶段起着非常重要作用。

A modified method bibed on the classical target factor analysis,refeed to as calibration working mains-TFA,waS used to perform a simultaneous determination-of a single or several mixture samples of food pigment s by confirming a corresponding calibration working matrix.

采用由目标因子分析法改进形成的校准工作矩阵法，对多组分食用合成色素混合体系进行同时测定。该法通过确认一个相应的校准工作矩阵即可对单个或多个混合样品的各组分进行同时直接测定。对七种三组分食用色素样品（各组分浓度在4.32～21.00μg／ml）的分析，各组分的回收率在97.93％～104.80％之间。与传统的目标因子分析法比较，此法特别适用于定性组成及定量范围基本清楚的混合样品的例行分析

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失