合成代谢产物

Japanese scholars to study that red Qu bacteria have the following four medical effectiveness:(1) to reduce blood cholesterol, and the Red Aspergillus of secondary metabolic product Mona to Lin K, have a dampening cholesterol synthetic;(2) lowering blood sugar;(3) lower blood pressure;(4) preventive effect.

日本学者研究确信红曲菌具有以下四种医疗功效：（1）降低血胆固醇，机理是红曲霉的次级代谢产物莫纳可林 K ，具有抑制胆固醇合成的作用；（2）降血糖；（3）降血压；（4）防癌功效。

In the study, N4 -acetyl-sulfamethazine(N4 -ACE-SM2) was synthesized, the determination method of sulfamethazine(SM2) and N4-ACE-SM2 in sturgeon muscle and water were developed, bioconcentration and depuration of SM2 in the sturgeon were completed at last.

本研究合成了磺胺二甲嘧啶(SM_2)的主要代谢产物N~4-乙酰化磺胺二甲嘧啶(N~4-ACE-SM_2)，并建立了SM_2和N~4-ACE-SM_2在鲟鱼肌肉和水中的检测方法，进一步利用流水式鱼类试验，对SM_2在鲟鱼体内的生物富集和生物清除进行了研究。

Firstly, the SSH was used to isolate tissues or organs specific expression genes in different development stages of plant. These genes provide evidence for explaining the molecular mechanism of plant development. Then SSH was widely used to isolate genes related to resistance under biological or abiological stress in different plants and the molecular mechanism of the resistance was primarily elucidated.

首先， 官中的组织特异性表达的基因，为揭示植物生长发育过程的分子机理提供了有效手段；另外，在不同植物中，该技术被大量应用于分离各种生物及非生物胁迫条件下诱导表达的抗性相关基因，可以揭示植物抗逆的分子 SSH 技术已开始应用于分离与次生代谢产物合成相关的基因。

In this paper, the Medicine Resource Science studies of Radix Bupleuri also have been summarized. It shows that the genus Bupleurum are good pattern plants for the systematic study of biosynthesis of secondary metabolites at the molecular level.The genus Bupleurum (Apiaceae/ Umbelliferae) has around 150 species in the world, and the majority of which are distributed on northern hemisphere.

同时，本论文对中药柴胡的资源学研究内容进行了概述，结果表明国内外对于柴胡属植物的研究已有相当深度和广度，同时柴胡属植物具有丰富的种质资源和遗传多样性，因而适宜作为多种次生代谢产物生物合成途径以及相关蛋白质与基因系统研究的模式植物加以研究。

The cloning of corresponding biosynthetic gene clusters is essential for new drug discovery and yield improvement by metabolic engineering.

微生物产生众多结构和生物活性多样的次级代谢产物，其生物合成基因簇的克隆是药物创新和产量提高的必要前提。

Cloning of corresponding biosynthetic gene clusters is essential for new drug discovery and yield improvement by metabolic engineering.

微生物产生众多结构和生物活性多样的次级代谢产物，其生物合成基因簇的克隆是药物创新和产量提高的必要前提。

Analysis of the relationship between antagonistic activities and the detection results of secondary metabolites biosynthetic genes showed that they were not directly correlative.

对菌株的抗菌活性和细胞毒活性测定结果与次级代谢产物合成相关基因扩增结果进行比较发现两者无一一对应联系。

In order to overcome some of the disadvantages of plant cell suspension culture, such as variability and shear sensitivity of plant cells, limited transfer of oxygen to the culture, mixing and relative low metabolites production, etc.

本文针对悬浮细胞培养中植物细胞剪切敏感性、溶氧及混合困难和次生代谢产物合成能力低等问题，进行固定化长春花植物细胞培养生产生物碱过程的研究，主要涉及固定化方法、影响固定化长春花植物细胞合成生物碱能力因素、及有关固定化长春花植物细胞反应器等问题，应用模糊集理论探讨固定化细胞培养过程的基本规律。

For long-term treatments, the rat administered daily by gavages for six weeks, the results of OGTT showed that guava fruit water or alcohol extracts could reduce the plasma glucose level in the diabetic Wistar rats, however there was on significant difference in insulin level among all tested groups. The results of carbohydrate metabolism showed diabetic Wistar rats administered with 200 or 400 mg/kg BW of guava fruit water or alcohol extracts could decrease more than 15% glucose-6-phosphatase and fructose-1,6-bisphosphatase activities, and it also increase more than 12% glucose-6-phosphate dehydrogenase activities to reduce inhibitory hexokinase from reducing glucose-6-phosphate level.

在醣类代谢方面，实验结果发现糖尿病鼠灌食番石榴果实水及乙醇萃取物六周后，肝脏醣质新生作用中丙酮酸合成肝醣之关键酵素glucose-6-phosphatase及fructose-1，6-bisphosphatase的酵素活性会降低15%以上；另一方面肝脏glucose-6-phosphate dehydrogenase酵素活性则明显增加12%以上，并造成glucose-6-phosphate浓度减少，进而降低其对hexokinase的抑制(因为hexokinase受其代谢产物G-6-P的浓抑制)，因此加速肝脏葡萄糖的糖解作用。

The results show that during the development of the oriental tobacco leaves, the activity of acid invertase was decreased; the changes of GS reached its peak in the 20dans in Samsun, but in the 30dans in Basma and Canik ;the activity of PAL was decreased in the 30dans; The content of total nitrogen was decreased with the mature leaves, but nicotine、total carbon and soluble total sugar were increased. Different varieties, carbon and nitrogen metabolism key enzyme activity and the content of metabolites were different.

结果表明，在香料烟叶片发育过程中，酸性转化酶的活性均呈下降趋势；谷氨酰胺合成酶的活性Samsun品种在20d叶龄时最高，而Basma和Canik在30d叶龄时最高；苯丙氨酸解氨酶的活性均表现为30d时最低；随着叶片成熟总氮含量降低，烟碱含量升高，总碳、可溶性总糖随着叶片成熟其含量呈升高趋势；品种不同，碳氮代谢关键酶的活性及代谢产物的含量变化均有很大差异。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失