叶酸

When a lack of folic acid, some amino acids in each variable delay so that the formation of red blood cells in the process of nucleic acid synthesis of obstacles, red blood cell development and maturation blocked, causing giant erythroblastic anemia, folic acid can be used at this time for treatment, so folic acid also called the anti-anemia vitamin.

当叶酸缺乏时，某些氨基酸的互变受阻，使红血球形成过程中的核酸合成障碍，红血球的发育和成熟受阻，引起巨幼红细胞性贫血，这时可以用叶酸进行治疗，故叶酸也叫抗贫血维生素。

It might be due to the increase during pregnancy in folate uptake capacity via altered hormone regulation. In pregnant women without folate supplement, levels of folate metabolites varied, which was associated with genotypes of MTHFR, MTR, MTRR, ALDH1L1, and AMT. The 5FoTHF/5,10CHTHF ratio is relatively low in pregnant women carrying heterozygotic SNPs of MTHFR, MTRR, ALDH1L1 genes. It may be as a maker for evaluating genetic effects on folate maintenance.

在未服用叶酸的受试者中，叶酸代谢途径的MTHFR、MTR、MTRR、ALDH1L1、AMT等基因型对於叶酸各代谢物的浓度均有显著性影响，而5FoTHF/5，10CHTHF在MTHFR、MTRR、ALDH1L1的5个SNP中发现具变异型配子的受试者有比值较低的趋势，可以作为单纯评估个体受到来自於基因型层面影响的依据。

The purpose of this study was to examine whether maternal iron and/or folate status influences human milk folate secretion and is responsible for growth faltering of Otomi infants in Capulhuac, Mexico. Breast-feeding mothers (n = 71) were randomized at 22 +/- 13 d postpartum to receive a daily multivitamin supplement containing folic acid (400 microg) with and without iron (18 mg).

本研究检测墨西哥Capulhuac市经剖宫产母亲体内铁和/或叶酸水平是否影响乳汁中叶酸盐分泌，并探究是否与剖宫产婴儿生长缓慢有关。71例，平均产后22+/-13天，均母乳喂养，每日补充多种维生素包括叶酸(400mg/d)，按是否补铁随机分为两组，补铁组(18mg/d)。

The purpose of this study was to examine whether maternal iron and/or folate status influences human milk folate secretion and is responsible for growth faltering of Otomi infants in Capulhuac, Mexico. Breast-feeding mothers (n = 71) were randomized at 22 +/- 13 d postpartum to receie a daily multiitamin supplement containing folic acid (400 microg) with and without iron (18 mg).

本研究检测墨西哥Capulhuac市经剖宫产母亲体内铁和/或叶酸水平是否影响乳汁中叶酸盐分泌，并探究是否与剖宫产婴儿生长缓慢有关。71例，平均产后22+/-13天，均母乳喂养，每日补充多种维生素包括叶酸(400mg/d)，按是否补铁随机分为两组，补铁组(18mg/d)。

In experiment 1, a 5 weeks folate depletion protocol was employed, using 13-week old Hyline pullets assigned to receive a semi-purified folate-deficient diet or a commercial corn-soybean meal based diet supplemented with 1 mg/kg pteroylglutamic acid.

试验一：以叶酸缺乏之半纯化饲粮餵饲十三周龄之新母鸡，为期五周，藉以了解新母鸡叶酸缺乏时，血液相及血液生化值的变化，以作为叶酸是否缺乏之指标。

We choose the solid phase extration to deal with the biolog...

本文采用固相萃取法对叶酸血浆样品进行前处理，首次应用大孔吸附树脂作为萃取固定相，同时，还研究了叶酸的光化学行为，发现叶酸本身有弱荧光，在一定的反应介质中，经光化学诱导，可产生较强的荧光产物，从而明显改善检测灵敏度。

Results showed that shoot biomass of H. annuus was significantly higher than that of R. acetosa and R. hastatus; among three plant species, 134Cs specific activity in shoots was the highest in H. annuus after 50 d-treatment, however after 70 d-treatment, that in R. acetosa was the highest. Bioaccumulation ratio reached 1.5, 1.4 and 1.3 in R. acetosa, R. hastatus and H. annuus after 70 d-treatment, and the former two plants kept with trend of continuously increasing. Three plants were resistant to 134Cs contaminated soil and capable of translocating 134Cs from soil to plants. Among them, H. annuus removed greatest 134Cs amount in the aboveground part during the experiment period, and R. acetosa, R.

结果表明，向日葵地上部生物量显著高于酸模和戟叶酸模；处理50d时，向日葵地上部134Cs比活度在3种植物中达到最高，而在处理70d时，酸模地上部134Cs的比活度达到最高；处理70d时，酸模、戟叶酸模和向日葵对134Cs的富集系数均大于1，分别达到1.5、1.4和1.3，且前2种植物继续保持快速上升的趋势。3种植物对铯污染土壤具有一定的忍耐性，并具有较强的从土壤向植物转移铯的能力；在本实验期内（70d）向日葵对土壤中放射性铯的剔除能力最强，而酸模和戟叶酸模则具有更强的铯转移能力。

Folate,Folic Acid,Folacin

叶酸，叶酸，叶酸 800微克200

The invention provides a compound for preventing foetus neural tube abnormality and pregnant woman iron deficiency anemia and its manufacturing method, it includes active ingredients and carrier, the active component is mainly made up of 1:25 weight ratio of folacin and hemin, the dosage is: folacin 0.2-0.6mg, hemin 5-15mg, the carrier is 150-300g of mannitol, the product can be produced through following steps and order: the hemin and mannitol are put into the mixer to be mixed for 0.5-1.5 hours according to same-size scale-up method, and they are crashed and filtered with 100 items sift and they are diluted, then they are blended with folacin, and carries pelleting or making capsule, pill and so on, it can prevent the foetus neural tube abnormality and it can prevent the pregnant woman iron deficiency anemia.

本发明提供一种预防胎儿神经管畸形和孕妇缺铁性贫血病的组合物及其制备方法，它包括活性成分和载体，其中活性成分主要由重量比为1∶25的叶酸与氯高铁血红素组成，用量为：叶酸0.2～0.6mg、氯高铁血红素5～15mg，载体为甘露醇150～300g，并按以下步骤和次序配制而成：氯高铁血红素与甘露醇按等量递加法放置在混合机中混合0.5～1.5小时，一起粉碎过100目筛制成稀释散后，再与叶酸混合均匀，直接压片或者制成胶囊、丸剂等剂型，不仅预防胎儿神经管畸形，而且能够同时预防孕妇缺铁性贫血。

AtDFA is dihydrofolate synthase localized in mitochondria, it catalyzes one glutamate added to the dihydropteroate and produces dihydrofolat. AtDFB, AtDFC and AtDFD are folylpolyglutamate synthase localized in plastid, mitochondria and cytosol respectively. A short chain ofγ-linked glutamates can be added by FPGS.Folate molecules exist in vivo mainly as polyglutamates and these are preferred by folate-dependent enzymes.

AtDFA为二氢叶酸合成酶(dihydrofolate synthase，DHFS)，定位于线粒体，在它的催化作用下，一个谷氨酸分子与二氢蝶酸(dihydropteroate ， DHP)相结合，形成二氢叶酸；AtDFB、AtDFC、AtDFD为多聚谷氨酸合成酶(folylpolyglutamate synthase，FPGS)，分别定位于质体、线粒体和细胞质，在多聚谷氨酸合成酶的作用下，谷氨酸分子可以逐一连接到四氢叶酸的谷氨酸γ位。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。