可证实的

At the same time, on the base of analysis of the present situation, the development trend and the leading edge technology, the necessity and feasibility about the exploitation of the full hydraulic bulldozer"s sate monitoring and fault diagnosis system is given; According to the structure, working feature and working environment, it works out system schema and system composition; The system is divided into display module, communication module and fault diagnosis module by means of block design, the implementation method and key parameter are also given; In light of the features of the full hydraulic bulldozer, the state monitoring and fault diagnosis platform composed of controller RC6-9 and display DI2/10 is designed based on CAN-Bus and the hardware design is completed; It lists the measured values and state of monitored parameters which should be real-time displayed in monitoring module as well as the data which will be transmitted; Furthermore, On the base of the study of, it gives 34 kinds of constant faults" diagnosis methods; Using BODAS software and DPS software, it compile the program code of the controller and the displayer; At last, this paper design and make the simulation test device of control system of construction machinery, through the experiment, the realizability, the categoricalness, the reliability, the stability and real-time are tested, in addition, the improved methods are given.

本文收集整理了国内外智能推土机研究的相关文献资料，综合分析了国内外智能推土机的研究现状、发展趋势和前沿技术，论证了开发全液压推土机智能系统的重要组成部分&全液压推土机状态监测与故障诊断系统&的必要性和可行性；根据全液压推土机的结构、作业特点和作业环境，制定了全液压推土机状态监测与故障诊断系统方案，确定了系统的结构组成；采用模块化设计方法，将整个系统分成了显示、通信和故障诊断三个模块，给出了各模块功能的实现方法，确定了各模块的关键技术参数：选用RC6-9和DI2／10作为系统的控制器和显示器，用CAN总线搭建了系统的通信平台，完成了系统的硬件设计；确定了系统监测参数和通信数据，对全液压推土机常见故障特征进行了分析，给出了34种常见故障的诊断方法；在BODAS软件和DPS软件的集成编程环境下，编写了控制器和显示器程序；设计并制作了工程机械控制系统模拟试验板，并在此基础上通过多次的程序调试与试验，对所设计的全液压推土机状态监测与故障诊断系统功能的可实现性、完备性、可靠性、稳定性和实时性进行了检验，证实了此系统的可行性，并提出了进一步的改进方案和措施。

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

As an immunomodulator NO may play a role like a double-edged sword since it expresses both in immuonchalleged and immunosspresed states. 2. After received external stimulus the morphology of ependyma of SFO could be changed and varied with time course, particularly its cellular apoptosis do occur and earlier than the ordinary areas of the brain. 3. Astrocytes in SFO could express cFos protein induced by LPS, suggesting the cells may maintain homeostasis in the brain in a longer period and modulate immune state of the brain. 4. As a CVO, SFO may sense changes of blood-bearing immunosignals earlier and instantly response to them, thus as one of windows of the brain SFO do take part in immunomodulation within the brain.

通过我们的实验结果我们可以得出这样一些初步的结论：1、一氧化氮作为免疫调质参与了机体免疫，它既能在免疫激发状态下又可在免疫抑制状态下进行表达提示，NO在脑内免疫调节中的作用可能是双向的。2、穹窿下器的室管膜形态在接受外界刺激后，随着时间的变化而不同，扫描电镜下的凋亡形态虽需进一步证实，但室管膜细胞确实发生了凋亡，并且穹窿下器发生的较早。3、穹窿下器内的星形胶质细胞在给予大肠杆菌后确实可以表达c-fos蛋白，并可能通过自身的激活来较长时间的维持体液的动态平衡，调节脑内免疫状态。4、穹窿下器作为感受性室周器官之一，能够较早的感受血携免疫信息的改变并及时作出反应，可能作为外周免疫信息进入脑内的窗口之一来参与脑的免疫调节。

Asked by Medscape Oncolo gy to comment on this finding, Jayne Franklyn, MD, PhD, from Queen Elizabeth Hospital, in Birmingham, United Kingdom, who was not involved with the study, said:"This is an important study, as it involved a large number of patients with a relatively rare form of thyroid cancer, specifically looking at those with the sporadic or noninherited variety of this cancer, and it presents the intriguing possibility that the presence of the mutation is associated with a prediction of tumor behavior and therefore prognosis."

Medscape肿瘤学邀请英国伊丽莎白皇后医院的Jayne Franklyn医师对此发现进行评论，未参与此研究的Franklyn医师表示，这是一个重要的研究，因为它纳入了此一少见甲状腺癌的许多病患，特别是此癌症的偶发或者非遗传变化，且展现出突变与预后有关的可能性；此外，该研究有潜在的临床冲击，但是首先，这些发现需要有其他研究证实重现；这项研究也指出各种甲状腺癌的基因突变与基因表现可提供预后资讯的远景。

Asked by Medscape Oncology to comment on this finding, Jayne Franklyn, MD, PhD, from Queen Elizabeth Hospital, in Birmingham, United Kingdom, who was not involved with the study, said: \"This is an important study, as it involved a large number of patients with a relatively rare form of thyroid cancer, specifically looking at those with the sporadic or noninherited variety of this cancer, and it presents the intriguing possibility that the presence of the mutation is associated with a prediction of tumor behavior and therefore prognosis.\"

Medscape肿瘤学邀请英国伊丽莎白皇后医院的Jayne Franklyn医师对此发现进行评论，未参与此研究的Franklyn医师表示，这是一个重要的研究，因為它纳入了此一少见甲状腺癌的许多病患，特别是此癌症的偶发或者非遗传变化，且展现出突变与预后有关的可能性；此外，该研究有潜在的临床冲击，但是首先，这些发现需要有其他研究证实重现；这项研究也指出各种甲状腺癌的基因突变与基因表现可提供预后资讯的远景。

Conclutions Topotecan is an effective remedy for treatment of small cell lung cancer, both single topotecan and combined regimen has the same effect as the traditional first-line regimen, though myelo-suppression such as leucopenia and thrombopenia is more sever, the adverse effect is tolerated. Though it has been recommended as second-line agent for chemo-therapy sensitive small cell lung cancer, there needs more clinical studies to verify its role in first-line.

结论拓扑替康是在小细胞肺癌的治疗中有确切临床疗效的药物，无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效，虽具有相对高的致白细胞和血小板下降的骨髓毒性，但毒副作用可耐受，已经被认为是治疗对化疗敏感的小细胞肺癌患者的二线推荐药物，但是作为一线用药仍然需要更多的临床证据来证实。

The entire political practice of the present regime, as I have tried to outline it here step by step, confirms that those concepts which were always crucial for its program-order, calm, consolidation,"guiding the nation out of its crisis,""halting disruption,""assuaging hot tempers" and so on-have finally acquired the same lethal(causing or sufficient to cause death)meaning that they have for every regime committed to entropy.

这种现存制度的全部政治实践，像我在这里逐步描绘的，进一步证实了对它的纲领来说总是关键性的概念——秩序、安定、稳固，&带领民族走出危机&&停止分裂&&缓和激烈的情绪&等等——最终得到每一个提交*(这种译法殊为怪异，可译为&委身&)给熵的制度所具有的同样致命的意义。

multi-channel correlators are widely used in traditional pseudo-random code cw radar,which makes the ranging system more complicated.this paper proposes a method of digitalizing the return signal directly and then convoluting the signals on dsp,which can replace multi-channel correlation in analog circuit.but the computation of convolution is too huge for the dsp to fulfill.to solve this problem,this paper analyzes five fast algorithms including fft,and then chooses one according to the characters of prc-cw radars.the digital method and fast algorithm have been verified by simulated signal and real signal.

一种提高空间伪码扩谱测距精度的实用。。。摘要：传统的伪码调相连续波雷达采用多路模拟相关电路实现对回波信号的相关接收，通过多路试探搜索各距离单元的目标，电路复杂。提出的数字化方案，对回波信号直接数字化，利用高速dsp实现数字卷积，可替代多路模拟相关电路。但是直接卷积的运算量过大，dsp无法承受。本文对此进行了研究，分析了包括fft在内的五种快速算法，结合prc-cw雷达的具体情况，确定了一种适于dsp实现的快速卷积算法。仿真和实测数据证实了数字化方案及快速算法的正确性。

multi-channel correlators are widely used in traditional pseudo-random code cw radar,which makes the ranging system more complicated.this paper proposes a method of digitalizing the return signal directly and then convoluting the signals on dsp,which can replace multi-channel correlation in analog circuit.but the computation of convolution is too huge for the dsp to fulfill.to solve this problem,this paper analyzes five fast algorithms including fft,and then chooses one according to the characters of prc-cw radars.the digital method and fast algorithm have been verified by simulated signal and real signal.

摘 要：传统的伪码调相连续波雷达采用多路模拟相关电路实现对回波信号的相关接收，通过多路试探搜索各距离单元的目标，电路复杂。提出的数字化方案，对回波信号直接数字化，利用高速dsp实现数字卷积，可替代多路模拟相关电路。但是直接卷积的运算量过大，dsp无法承受。本文对此进行了研究，分析了包括fft在内的五种快速算法，结合prc-cw雷达的具体情况，确定了一种适于dsp实现的快速卷积算法。仿真和实测数据证实了数字化方案及快速算法的正确性。

Some strains of the nematode-bearing bacteria were bioassayed for their parasitism. All these bacteria can totally not grow or grows badly on the media incorporating the extracts of pine trees, indicating some substances existing in the trees will harmful to the bacterial strains, which is further convinced by preliminary inoculation showing that single bacterial species will not infect Pinus thugbergii. Hence, the growth and reproduction of the nematode-carrying bacteria, which could produce toxic substances causing the death of the tree cells, is closely related to the nematodes, when they first enter to the trees. In the same time, the activity of bacteria improved the circumstances for which nematodes are living, which in turn will beneficial to the growth of nematodes. Thus, there is a complicated interaction among nematodes, bacteria, and pine trees.

对松材线虫携带的细菌的部分菌株进行了寄生性测定，表明这些细菌在添加松树提取液的细菌培养基中不能生长或基本不能生长，这说明松树体内可能存在某些不利于细菌生长的物质，同时初步的接种试验证实，单独的细菌接种不能感染健康的黑松，因此，线虫携带的致病细菌在最初进入树体时，其生长和繁殖与线虫密切相关，结合细菌产生的毒性物质可造成黑松细胞死亡的情况，说明细菌的生长与线虫有关，同时，细菌的活动改变了线虫在松树内的生长环境，使环境变得有利于线虫的生活，因此，线虫、细菌和松树三者存在着复杂的生物关系。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐