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Rapid eye movement sleep consists of a dreaming state in which there is activation of the cortical and hippocampal electroencephalogram, rapid eye movements, and loss of muscle tone. Although REM sleep was discovered more than 50 years ago, the neuronal circuits responsible for switching between REM and non-REM sleep remain poorly understood. Here we propose a brainstem flip-flop switch, consisting of mutually inhibitory REM-off and REM-on areas in the mesopontine tegmentum. Each side contains GABA (gamma-aminobutyric acid)-ergic neurons that heavily innervate the other.

快动眼睡眠是一个包括有皮层和海马脑电活动的睡梦状态,可见眼球的快速运动和肌张力减低,尽管快动眼睡眠已经被发现50余年了,对其与非快动眼睡眠之间的神经回路却知之甚少,我们用脑干触发转换器,包括脑桥背盖区一个互相抑制的快动眼-关、快动眼-开区域,每侧均包含高度互相支配gamma氨基丁酸能神经元。

RESULTS: Four hours after operation, rats injected with bletilla particles developed temporary conscious disturbance, and sustained hemiparesis of contralateral limbs with spontaneous circling behavior. Ischemia or infarction was found obviously in the cortex of parietal, frontal lobes and basal nuclei of the right cerebral hemisphere, where the neurons characterized with vague outlines, pyknosis and necrosis of neuron nuclei were recognized as well. But hemiparesis and spontaneous circling behavior only lasted for 12 h after embolization with bletilla gum.

结果:白芨微粒组大鼠术后4 h内呈现意识障碍,持续性对侧肢体轻度偏瘫及环转,TTC染色显示右侧大脑半球额叶、顶叶皮层和基底核附近局灶性缺血或梗塞,光学显微镜下可见缺血区脑组织水肿或坏死,神经元轮廓模糊,核固缩或裂解等;白芨胶组仅在术后术后1 h内有轻度意识障碍,12 h内出现对侧肢体行动障碍,但未见明显病理改变。

Results showed that after injection of HRP into medial recteus subnucleus of oculomotor nucleus,HRP labelled cells were found in contralateral abducens nucleus and also in vestibular nucleus and pontine ...

结果表明:注射HRP于大鼠动眼神经核内直肌亚核后,在对侧展神经核区以及前庭神经核、脑桥旁正中网状结构中发现HRP单标记细胞;在前庭神经核内,可见HRP单标记、GABA阳性和HRP/GABA双标记三类神经元,其中HRP/GABA双标记细胞占HRP标记细胞总数的47.1%。

High signal was seen in the anterolateral columns of the cervical spinal cord on T1-weighted images in 14 patients (cases 1, 2, 4, 6, 7, 9-15, 17 and 20)(Fig. 3 a), but not in controls.

在所有21例ALS患者中有14例患者(病例1、2、4、6、7、9~15、17、20)在T1像上于颈髓的前外侧柱区可见高信号病灶(图3a),但在正常人对照组、其他神经疾病患者组均未发现。

Results: Neonatal rats in hypoxic-ischemicgroup behaved restlessness, cyanosis, deep and rapid breath, astasia, lethargy, irritation and spasm; There were local pyknosis, fragmentation, dissymmetry, blur or disappearance of nucleoli, raritas of ground substance in left cerebral cortex; but there was no statistic significance in chinese traditional medicine group and sham group. The expression of HIF-1α mRNA in brain tissue of experimental group and chinese traditional medicine group were higher than that in sham group, especially chinese traditional medicine group at 3d; HIF-1α positive cells were found in cerebral cortex and hippocampus. There were more HIF-1α positive cells in experimental group and chinese traditional medicine group and mainly in vascular endothelial cells.

结果 缺氧缺血后大鼠相继表现为烦躁不安、全身发给、呼吸加深加快、站立不稳、嗜睡、激惹或间断发作的痉挛和抽搐;HE染色显示实验组大鼠左侧大脑皮层出现局灶性神经元核固缩,核碎裂,核仁偏位,不清或消失,基质疏松;中药组大鼠脑组织结构基本接近假手术组,无明显水肿和坏死表现;实验组和中药组大鼠脑组织HIF-1α mRNA表达较假手术组明显增加,尤其是中药组实验第3日者;免疫组化显示实验组和中药组各时间点大鼠大脑皮层和海马区均可见不同程度的HIF-1α表达,明显高于假手术组,阳性表达主要在血管内皮细胞,海马和皮层的锥体细胞亦有HIF-1α阳性细胞分布。

As barbituric acid and riboflavin was respectively added into PC/4 coliposomal solution, the absorbivity of barbituric acid at 258 nm, and riboflavin at 222 nm and 264 nm decreased slowly with time. The onset of a hypochromic effect can be ascribed to adeninebarbituric acid or riboflavin interaction.

紫外可见光谱研究表明,底物巴比妥酸在258 nm的吸收峰,核黄素在222 am,264 nm的吸收峰随时间的延长而逐渐降低,这种减色作用归因于脂质体内的巴比妥酸和核黄素在亲脂区分别与双亲化合物上的腺嘌呤形成了氢键。

The results demonstrated that MC1R gene of bird was relatively conserved. The results of phylogenetic analysis showed that consanguinity relations between mule duck, anas platyrhynchos and branta bernicla, anser caerulescens, anser canagica were close.The status of them were confirmed on zoologyl by means of molecular method.

可见禽类的MC1R 基因编码区序列具有高度的保守性;系统进化分析表明,半番鸭、北京鸭与雪雁、黑雁、皇雁亲缘关系相近,从分子角度验证了它们在动物学分类上的地位。

Low signal was also seen in the motor cortex on T2-weighted images in three of the eight normal volunteers and four of the 16 disease controls: one with a bulbospinal muscular atrophy, two with leukoencephalopathy and one with Binswanger's disease.

在8例正常人对照者中有3例、16例其他神经疾病患者中有4例(1例脊髓延髓性肌萎缩症患者、2例表现为下肢痉挛性轻瘫的不明原因的白质脑病患者、1例表现为痴呆和下肢痉挛性轻瘫的皮质下动脉硬化性脑病患者)在T2像上于运动皮质区也可见低信号。

The expression of Bcl-2mRNA and P53mRNA in hippocampus after 16Hz, 130dB infrasound treatment In 1 day group, Bcl-2mRNA and P53mRNA were expressed lightly in CA1-CA3 areas in hippocampus and dentate gyrus. Blood vessels dilated lightly. In 7d group, Bcl-2mRNA and P53mRNA were more expressed in areas mentioned above. Dilation of capillaries and small vessels was more obvious. Bcl-2mRNA and P53mRNA were strong positive in endothelial cells of vessels. In 14d group, Bcl-2mRNA and P53mRNA expression was obviously increased in pyramidal cells of hippocampus and granular cells of dentate gyrus, showing deep blue staining. a The endothelial cells in some vessels were also strong positive for Bcl-2mRNA and P53mRNA. Dilation of capillaries and small vessels was lessened. In 21d group, Bcl-2mRNA and P53mRNA expression was decreased in pyramidal cells. In 28d group, little change about the expression and distribution of Bcl-2mRNA and P53mRNA was observed. Lots of Bcl-2mRNA and P53mRNA were scattered in cortex of temporal lobe around hippocampus and callosal gyrus area. Dilation of capillaries and small vessels was lessened obviously. The expression of Bcl-2mRNA and P53mRNA in hippocampus after 16Hz, 90dB infrasound treatment.

次声作用后Bcl-2mRNA和P53mRNA在海马的表达,16Hz、130dB次声作用1d组:两者在海马〓区和齿状回轻度表达,海马内血管轻度扩张;7d组:两者表达在上述区域较1d增多,微血管和小血管扩张较显,血管内皮细胞内可见呈强阳性表达的Bcl-2mRNA和P53mRNA;14d组:海马锥体细胞和齿状回颗粒细胞内Bcl-2mRNA和P53mRNA阳性表达明显增多,呈深兰色,在部分血管内皮细胞内两者强阳性表达,微小血管扩张状态较7d减轻;21d组:锥体细胞胞浆内Bcl-2mRNA和P53mRNA表达减弱;28d组:上述表达及分布与21d组相比无明显改变,海马周围颞叶皮层和扣带回区域亦可见大量散在分布的Bcl-2mRNA和P53mRNA表达,血管扩张状态已明显减轻。90dB次声作用1d-7d后,较对照组无明显变化,14d-21d后轻度表达,28d后,Bcl-2mRNA和P53mRNA表达较强。

In the intercellular space of the hepatocytes and tight junctions of bile canaliculi, TPPase reaction could be seen.

肝细胞间隙和毛细胆管紧密连接区可见TPPase反应物。

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