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Here, using a strategy of re-expressing key developmental regulators in vivo, we identify a specific combination of three transcription factors Ngn3 (also known as Neurog3 Pdx1 and Mafa that reprograms differentiated pancreatic exocrine cells in adult mice into cells that closely resemble beta-cells.

这里,在体内通过一种策略将生长发育中关键的调控因子进行再表达,我们鉴定出了一系列3个转录因子(Ngn3 (亦称 Neurog3),Pdx1 和 Mafa),将它们重组入成年小鼠的胰腺外分泌细胞,相应的细胞可分化成类似于β细胞的细胞。

Based on GIS and water pollution model, the paper discusses sulfured pollution in Yellow River, analyses diffusion equation of sulfured pollution, implements visible presentation, provides a new method for water pollution control and management.

本文以黄河某河段的硫化物污染为例,基于GIS技术和水环境数值模拟方程,研究污染物在水环境中的运移扩散规律,并实现污染物扩散的可视化表达,探索污染控制和治理的新方法。

After prolonged culture, the cells formed teratomas when injected into seere combined immunodeficient beige mice and expressed markers characteristic of undifferentiated human ES cells.

经过长时间的培养,在注射到合并严重免疫缺陷的beige小鼠体内后,这些细胞仍可形成畸胎瘤并表达未分化的人ES细胞的特征性标记物。

Among the ante-Nicene writers, a certain ambiguity of expression may be detected, outside the school of Alexandria, touching this last head of doctrine.

其中前厅nicene作家,有一定的模糊性的表达,可发现,在学校外的亚历山德里亚,在谈到最后这头的教义。

It has been shown that both SA and JA are in wounding signal transduction pathways. It has been suggested that cytokinins and small GTP_binding proteins might be the switch of JA and SA signaling pathways.

水杨酸可抑制茉莉酸类的合成及其所诱导的蛋白基因的表达;茉莉酸能阻止病原侵染后所产生的水杨酸的增加。

5-LOX participate in the formation of retinal neovascularization,Selective inhibition of 5-LOX can reduce the expression of VEGF and its receptor KDR, its specific mechanism may be associated with inhibition of ERKs signaling.

5-LOX参与视网膜新生血管的形成,通过对其选择性抑制可下调VEGF及受体KDR的表达从而抑制新生血管的生成,具体机制可能与抑制5-LOX激活MAPKs信号通路的外部ERKs有关。

RESULTS: Analysis of T cell activation in vitro revealed that preincubation of PBMC with 100 μmol/L gossypol could completely inhibit the expression of early activation marker CD69 on CD3+ T cells in response to 10 mg/L PHA, and block T cell activation by 10-7 mol/L PDB as well.

结果: 100 μmol/L的棉酚预先与T细胞温育,能完全抑制10 mg/L植物血凝素刺激的CD3+T细胞活化抗原CD69的表达,又可阻断10-7 mol/L佛波醇酯对T细胞的活化作用。

The major clinical manifestation was lymph node enlargement found in all patients. Skin involvement and osteolysis were not frequent. The characteristic finding was leukemic cells with highly indented or lobulated flower-like nuclei in peripheral blood and bone marrow. ATL cells were CD2,CD3,CD4,CD25 positive and CD8 negative. No specific chromosome abnormality or HLA type was found. Seven of 8 patients examined had HTLV-Ⅰ antibody. The HTLV-Ⅰ provirus genome sequence integrated into host cell DNA was amplified by PCR and confirmed by liquid hybridization. All of these results showed that HTLV-Ⅰ was also the etiological agent of ATL in China. One of the 9 cases of ATL was classified as lymphoma type, one as chronic-type, and the rest as acute type.

结果和结论确诊9例ATL,其临床特征主要为淋巴结肿大,皮损及溶骨改变少见,外周血及骨髓出现典型的花瓣状核淋巴细胞,胞体大,核畸形,免疫表型为CD-1、CD+2、CD3+、CD4+、CD-8,还表达CD25等激活标记,染色体核型及HLA分型未发现有规律性的变化。8例ATL中有7例血清HTLV-Ⅰ抗体阳性,应用PCR及液相杂交法可检出整合到宿主细胞DNA中的HTLV-Ⅰ病毒序列,表明在我国HTLV-Ⅰ也是ATL的病因。9例中1例为淋巴瘤型,1例为慢性型,7例为急性型ATL,治疗效果及预后均不良。

Theresults show that the tempreture changes can affect the growth of the transgenic cotton and theexpression of the Bt insecticidal gene and therefore affect the timing and the onsetting of thetransgene silencing. The time of the occurrence of silencing is more earlier after hightemperature treatment.

结果表明,温度变化影响抗虫棉早期的生长发育和Bt杀虫基因的表达,从而影响Bt杀虫基因沉默的发生时间,前期高温处理可使Bt杀虫基因在生长发育期中的沉默时间提前。

Those lacking a distinct border=0 title, such as junior siblings of peers (and perhaps even the children of 'self-made' VIPs) may be considered aristocrats, moving within a small social circle at the apex of a hierarchical social pyramid. Blue blood is an English expression for noble birth or descent.

它们缺乏可区分性,比如在世袭金字塔顶端的小圈子里游荡的英国贵族年轻的兄弟姐妹(甚至也许是儿童自封的VIP),也被认为是aristocrats,&蓝血&是贵族出身的英国式表达。

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It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发,分析对称连杆曲线上鲍尔点的产生条件,提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品,年生产总值3000万美元,产品价廉物美、选料上乘、质量保证,深受国内外客户的青睐

The eˉtiology of hemospermia is complicate,but almost of hemospermia are benign.

血精的原因很,以良性病变为主。