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In this paper, the stable Au complexes are classified according to the coordination atoms and their characteristic structure. The recent development of the researches on the antitumor activity of Au complexes including the structure-activity relationship, biological targets and the mechanisms of action are reviewed. The structure of the coordination ligand and the leaving group have great impact on the in vitro cytotoxicity of the Au complex. Many physical and biological methods are introduced to study the interaction between the Au complexes and the suspected bio-target, such as DNA, protein, mitochondrion, thio-containing biomolecules, etc. The interaction modes (intercalating, electrostatic interaction, covalent bonding, etc.) are focused to illustrate the reason for the antitumor activity of Au complexes.

本文按配位原子的不同总结了稳定三价金配合物的结构特征,按其生物活性的构效关系、生物靶点和作用机制综述了三价金配合物抗肿瘤活性研究的最新成果:配体的结构特点以及离去基团对三价金配合物的体外细胞毒性影响较大;介绍了用于检测三价金配合物与可能的生物靶分子之间的相互作用的多种物理和生物学方法,重点关注了相互作用的模式,如嵌入/静电吸引/共价结合等,并解释了三价金配合物抗肿瘤活性的原因。

In this paper, the stable Au complexes are classified according to the coordination atoms and their structural characteristics. The recent development of the researches on the antitumor activity of Au complexes including the structure-activity relationships, biological targets and the mechanisms of action are reviewed. The structure of the coordination ligand and the leaving group have great impact on the in vitro cytotoxicity of the Au complex. Many physical and biological methods are introduced to study the interaction between the Au complexe and the suspected bio-target, such as DNA, protein, mitochondrion, thio-containing biomolecules, etc. The interaction modes (intercalating, electrostatic interaction, covalent bonding, etc.) are focused to illustrate the reason for the antitumor activity of Au complexes.

本文按配位原子的不同总结了稳定三价金配合物的结构特征,按其生物活性的构效关系、生物靶点和作用机制综述了三价金配合物抗肿瘤活性研究的最新成果:配体的结构特点以及离去基团对三价金配合物的体外细胞毒性影响较大;介绍了用于检测三价金配合物与可能的生物靶分子之间相互作用的多种物理和生物学方法,重点关注了相互作用的模式,如嵌入/静电吸引/共价结合等,并解释了三价金配合物抗肿瘤活性的原因。

Obama didn't name them all, but a decent list would look something like this: new technologies that have made some blue-collar work obsolete; a slowing in the nation's educational attainment; the shriveling of labor unions; the increase in one-parent families, which are far less economically secure; and the rise of other countries that have huge low-wage work forces.

奥巴马没有明确指出这些原因,但一份可能的清单是这样的:新技术造成蓝领工人被抛弃;国家教育程度的缓慢增长;工会的萎顿;单亲家庭的增加,这对经济安全的影响较小;以及廉价劳动力国家的崛起。

Due to the VDW interaction between R2 substituent and flavin ring of FAD, the docking complex of inhibitors to AHAS became more stable. It was assumed that the unfavorable electrostatic interaction between the inhibitors and TPP may be the factor which accelerates the degradation of TPP.

其中FAD的加入使AHAS与抑制剂的结合更加稳定,这主要是由于抑制剂的R2取代基与FAD中的平面基团Flavin环间存在的范德华相互作用所致;抑制剂与TPP间存在的静电相互作用可能是加速TPP降解的原因。

We shall therefore revoke them, with due regard to justice, even though the authority of the apostolic see may have been involved, on the plea of the interested parties, unless they were made for good and true reasons or unless the interested persons themselves have obtained benefices united in this way.

因此,我们将撤销他们,并适当考虑到司法,即使权威的使徒见可能已经涉及,对认罪的兴趣,除非他们提出了很好的和真正的原因还是,除非有兴趣的人士,自己也获得了benefices美国这样做的。

High brain iron involved in the etiology of PD, while iron chelator desferrioxamine mesylate could protect DA neurons.

6.6-OHDA可导致Str的DA释放量及含量均减少,此过程有铁的参与,由于铁可导致DA神经元的死亡,SN内铁升高可使Str内DA释放量和含量均降低,因此铁含量的增加可能是DA含量减少的原因之一,铁离子螯合剂甲磺酸去铁胺具有保护DA神经元的作用。

The sheer size of the empire was reason enough for the Mongol collapse. It was too large for one person to administer, as Chingghis had realized, yet adequate coordination was impossible among the ruling elements after the split into khanates.

纯粹就庞大帝国的规模而言这一因素就是它崩溃的原因,正如成吉思汗所意识到的,一个人是无法管理其庞大国家的,而在分裂成为几个汗国之后,要在统治方式上找到恰当的融合点也是不可能的。

Mol/m2s low light treament cause leaf-upgrowth stopping, flower withering and losing fruit-settle capability. Fruit-settle efficiency enhance in 400μmol/m2s low light maybe because high light's injury on flowers are reducing. 200μmol/m2s and 80μmol/m2s low light treament cause carborhybrate synthesis decreasing, prevent carborhybrate's transforming to flower, lead to fruit-settle efficiency reducing. 30μmol/m2s low light is close to light compensation point of peach tree, which cause nutrition lackness, lead to peach tree's mechanism declining eventually.

表明400μmol/m2s的弱光提高花朵向幼果的转化可能是400μmol/m2s的弱光减弱了强光对花器的伤害的原因。200μmol/m2s和80μmol/m2s的弱光下,叶片合成的碳水化合物减少,向生殖器官的运转受到抑制,分配量减少,生殖生长减慢,落花延迟且花朵向幼果的转化率下降;30μmol/m2s的弱光已接近光补偿点,导致桃树营养缺乏,株体机能降低。

Based on the revised system,the vine life form spectrum analysis shows that the phanerophyte lianes are absolutely dominant,accounted for 72.7% of all vines,followed by the geocryptophyte vines(17.5%),the hemicryptophyte vines(6.2%),the therophyte vines(2.7%)and the chamaephyte vines(1.5%).

对本区生活型分析的结果表明,中国亚热带东部藤本植物的生活型谱是以高位芽藤本占绝对优势( 72 。7%)其次为地下芽藤本( 1 7.5%)、地面芽藤本( 6.2 %)、1年生藤本( 2 。7%)和地上芽藤本( 1 。5%),除地下芽藤本比例略高外,与亚热带常绿阔叶林生活型谱十分接近,具有比较明确的生态学意义;地下芽藤本比例略高的原因可能是由于该类藤本具有地下贮藏器官,因此有利于次年春天迅速的抽生攀援枝,较其他草质藤本更优先占领光合空间,这是对区域小生境长期适应的结果。

The USM is a kind of new electrical motor which develops in recent 20 years, it broke through the traditional concept of electrical motor. It didn"t have the electromagnetism winding and the magnetic circuit, and it didn"t uses the mutually electromagnetism to transform the energy, moreover, the volume of electrical motor is small, the weight is light, the transfer efficiency is high. For it was so small, so light, and so thin, it have begun to use on automobile. But the usage of superconductivity electrical motor is still in the experimental stage at present. The main reason is that the super conductivity material has not realized the high temperature, but with the development of technical, the possibly uses of superconductivity electrical motor in the big horsepower like automobile generator and on actuation electrical motor causes the electrical machinery to be smaller in volume, lighter in weight, and higher in efficiency.

超声波电机是近二十年来发展起来的一种新型电机,它突破了传统电机的概念,没有电磁绕组和磁路,不用电磁相互作用来转换能量,体积小、重量轻、转换效率高,很小、很轻、很薄,在汽车上已经开始使用;超导电机的使用目前还处在实验阶段,这主要的原因是超导材料还没有实现高温化,但是,随着技术的发展,超导电机可能使用在汽车的起动机和驱动电机这些大马力上,使原有的电机体积更小,重量更轻,效率更高。

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Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时,他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了

The enrich the peopling of Deng Xiaoping of century great person thought, it is the main component in system of theory of Deng Xiaoping economy, it is a when our country economy builds basic task important facet.

世纪伟人邓小平的富民思想,是邓小平经济理论体系中的重要组成部分,是我国经济建设根本任务的一个重要方面。