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When chondroitinase ABC was given to degradate CSPGs in the developmental nervous system such as the optic chiasm, the projection and destination of growing axons were altered. Also in SCI, ChABC treatment in the injuryed sites can increase regenerating ability of axons and improve spinal cord rehabilitation.

以往对发育阶段的神经系统如视交叉部位给予软骨素酶ABC降解CSPGs后,可观察到生长轴突延伸方向和终止部位的改变;SCI后,受损处给予ChABC处理,轴突再生能力可增加,脊髓功能有所恢复。

C Where the assured has no insurable interest throughout the currency of the risk, the premium is returnable, proviede that this rule does not apply to a policy effected by way of gaming or wagering; Where the assured has a defeasible interest which is terminated during the currency of the risk, the premium is not returnable; Where the assured has over-insured under an unvalued policy, a proportionate part of the premium is returnable; Subject to the foregoing provisions, where the assured has over-insured by double insurance, a proportionate part of the several premiums is returnable; Provided that, if the policy are effected at different times, and any earlier policy has at any time borne the entire risk, or if a claim has been paid on the policy in respect of the full sum insured thereby, no premium is returnable in respect of that policy, and when the double insurance is effected knowingly by the assured no premium is returnable.

c 如果在整个风险存在期间,被保险人无保险利益,保险费可予退回,但这一规则对赌博性保险单不适用。如果被保险人的可撤销的利益于风险存在期间终止,则保险费不能退回。如被保险人不定值保险单中超额保险,保险费得按比例退还一部分。除前述条款另有规定外,若被保险人经重复保险而超额保险,几笔保险费按比例退还。但是,如果几份保险单在不同时间开始生效,任何较早订立的保险单已在任何时间承保整个保险,或保险单已就全部保险金额支付赔偿,该保险单项下的保险费不能退回;若被保险人在明知的情况下订立重复保险,保险费不予退还。

1 Notwithstanding Clause 15,"Liability Exemption" hereinabove, in case of failure of the seller or the buyer (the Non-Performing Party) to comply with any of the obligations assumed under this contract, the other party, without prejudice to any other recourse available to them, may consider such failure as a breach of this contract and terminate the same, or to unilaterally suspend its performance until such failure is remedied, and in any case may claim direct damages for the breach of this contract from the other party, to the extent allowed by the terms and conditions set forth herein.

除了上文条款15 "免责声明"外,在卖方或买方未履行合同规定的任何义务的情况下,其他一方,对于没有提供任何其它意见的,可视为违约并考虑终止合同或暂时搁置合同的执行,直到这样的状况被矫正,若因此违约而受到直接损失可向违约方索赔,并且在违反合同规定时需提供声明。

Use in a rolling way, stay for a time at inflammative place or problematic skin to increase the effect.

口周部:由嘴角部开始,沿法令门做提升动作,然后向前轻轻滑动,终止在鼻根部,接下来,从鼻翼开始,沿面颊到耳前,冰球要顺着皮肤和肌肉的纹路方向轻轻滑动,不可逆行,在有问题的皮肤处,可做短暂停留,以安抚过敏皮肤,另一只手可做柔和的安抚,动作重复4、5遍。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速,应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等,其中自杀基因被认为是最有前景的基因治疗方法,它又称病毒介导的酶/药物前体疗法,是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中,该基因表达的产物可将无毒的药物前体转化为毒性药物,从而选择性杀伤该肿瘤细胞,常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因,前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物,然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷,作为DNA合成链的终止剂和DNA合成酶的抑制剂,干扰细胞DNA的合成;后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶(5-FC)脱氨成为5-氟尿嘧啶(5-FU),然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸(5-FUTP)和5-氟-2′脱氧尿嘧啶-5′磷酸(5-FdUTP),5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成,5-FdUTP则作用于胸苷合成酶,导致TMP衰竭而阻止DNA的合成,最终诱导肿瘤细胞凋亡。

Coding and non-coding sequences are expected to have very different patterns of sequence changes because of the following characteristics of coding sequences: biased codon composition, higher conservation, absence of stop codons and frameshifts, higher fraction of synonymous than nonsynonymous substitutions, higher frequency of substitutions corresponding to changes of chemically similar amino acids, higher proportion of mutable contexts.

我们可以预期可转录的序列及不可转录的序列会有相当不同的序列改变特徵,因为可转录的序列有以下特色:偏颇的密码子组成,较高的保存度,有终止密码子和移码的出现,相较於异义取代有较高比例的同义取代,较高的频率出现化学结构相似的胺基酸取代,较高比例的可变之前后序列。

This thread continues to run until it ceases to be runnable or another thread of higher priority becomes runnable.

该线程一直运行到它终止进入可运行状态或是另一个具有更高优先级的线程变成可运行状态。

An ultra-high strength, weldable, low alloy steel with excellent cryogenic temperature toughness in the base plate and in the heat affected zone when welded, having a tensile strength greater than 830 MPa (120 ksi) and a micro-laminate microstructure comprising austenite film layers and fine-grained martensite/lower bainite laths, is prepared by heating a steel slab comprising iron and specified weight percentages of some or all of the additives carbon, manganese, nickel, nitrogen, copper, chromium, molybdenum, silicon, niobium, vanadium, titanium, aluminum, and boron; reducing the slab to form plate in one or more passes in a temperature range in which austenite recrystallizes; finish rolling the plate in one or more passes in a temperature range below the austenite recrystallization temperature and above the Ar3 transformation temperature; quenching the finish rolled plate to a suitable Quench Stop Temperature; stopping the quenching; and either, for a period of time, holding the plate substantially isothermally at the QST or slow-cooling the plate before air cooling, or simply air cooling the plate to ambient temperature.

在基体板以及焊接时的热影响区处的低温韧性优异的超高强度、可焊接、低合金钢具有高于830MPa(120ksi)的抗拉强度,并且具有包含奥氏体薄膜层和细晶粒的马氏体/下贝氏体板条的显微层状组织,所述钢的制备过程为:加热含有铁以及特定重量百分比的添加元素的钢坯,所述添加元素为碳,锰,镍,氮,铜,铬,钼,硅,铌,钒,钛,铝,以及硼中的一些或全部;在奥氏体可发生再结晶的温度范围内,采用一个或多个道次,将所述钢坯轧制成板材;在低于奥氏体再结晶温度但高于Ar 3 转变点的温度下,采用一个或多个道次对所述板材进行终轧;将所述终轧板材淬火至一适当淬火终止温度;停止所述淬火;或者在空冷前在QST点基本等温保持所述板材一段时间,或者对所述板材进行缓慢冷却,或者只是简单地将所述板材空冷至室温。

Normal mammalian guanylate kinase metabolizes the monophosphate to the diphosphate form and then to the triphosphate form .

GCV-TP对细胞具有剧毒性,可抑制DNA聚合酶的活性,并可掺入到DNA链的末端作为终止剂。

If the progress of the solvent front is monitored closely, itis also acceptable to draw start and stop lines on the plate before the chromatogram is run (A pencil should be used because ink is soluble). This prevents inaccuracies that occur when the solvent evaporates before the final solvent front can be marked. Sketch the chromatograms in your lab notebook.

如果要密切监测溶剂前沿前进过程,可在进行层析前可以先把起始线和终止线先标上,这方法是可以接受的(应该用铅笔,因为墨水是可溶解的)这样的话可以避免由于溶剂前沿在被作标记前已挥发掉所引起的不准确度。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力