可注射的

It is that:(1) the related compounds in Metronidazole Buccal Tablets prepared by Chongqing Medical College can be tested by determining (321nm) the total peak area of the impurities;(2) The related compounds in Metronidazole Disodium Phosphate for Injection prepared by Chongqing Medical College can be test by determining (254nm) the total peak area of the impurities and the peak area of the largest impurity;(3) Ceftriaxone polymer in Ceftriaxone Sodium for Injection prepared by Chongqing Keru Pharmacy Co.

结果如下：①用HPLC一UV法，在321nm处检测，用归一化法计算，控制各杂质峰面积的和，可检查重庆医科大学的注射用甲硝吟磷酸二钠中的有关物质：②用HPLC一UV法，在254nm处检测，控制杂质峰面积的和及控制最大杂质峰面积，可对重庆科瑞制药股份有限公司的注射用头饱曲松钠中的有关物质实施控制；③用HPLC一Uv法，在254nm处检测，按外标法计算，可检查注射用头抱曲松钠中的聚合物；④用紫外分光光度法，在277nm波长处测定吸收度，按C6H9N303的吸收系数为377计算每片标示百分含量，可测定重庆医科大学的甲硝哇口颊片的含量均匀度；⑤用紫外分光光度法，在277run波长处分别测定释放溶液20min、50min和90min的吸收度，按甲硝哇(C6H剥303)的吸收系数为377计算释放度，可检查重庆医科大学的甲硝哇口颊片的释放度。

The research indicates that:(1) detecting λmax (277nm) can identify Metronidazole Buccal Tablets prepared by Chongqing Medical College;(2) detecting λmax (321nm) and λmin (265nm) can identify Metronidazole Disodium Phosphate for Injection prepared by Chongqing Medical College;(3) detecting tr (6.7min) in HPLC-UV spectrum can identify Ceftriaxone Sodium for Injection prepared by Chongqing Keru Pharmacy Co.;(4) detecting tR (10.2min) 6.7min in HPLC-UV spectrum can identify Clarithromycin Tablets prepared by Harebin Yida Pharmacy Co.;(5) detecting λmax (254nm) can identify Potassium Sodium Dehydroandroan Drographolide Succinate prepared by Hong Kong Yaohen Co..

结果表明：①测定紫外最大吸收波长λ_(max277nm可鉴别重庆医科大学医药研究所制备的甲硝唑口颊片；②测定紫外最大吸收波长λ_(max321nm和最小吸收波长λ_(min265nm可鉴别重庆医科大学医药研究所制备的注射用甲硝唑磷酸二钠；③测定HPLC-UV中的保留时间(t_R6.7min)可鉴别重庆科瑞制药股份有限公司制备的注射用头孢曲松钠；④测定高效液相色谱的保留时间(t_R10.2min)可鉴别哈尔滨伊达制药厂提供的克拉霉素片；⑤测定紫外最大吸收波长(又max254nm)可鉴别香港耀恒公司提供的炎琉宁。

An injection mechanism for an injection molding machine, including a front plate carrying an injection cylinder; a guide rod arranged fixedly relative to the front plate and having a longitudinal guiding axis; a movable plate arranged movably relative to the front plate along the guiding axis and carrying an injection screw; and a rear plate arranged at a location opposite to the front plate with the movable plate disposed therebetween.

一用于注射成型机的注射机构，包括：一支承压射缸的前板；一相对于所述前板固定布置并限定出一纵向导轴的导杆；一沿所述导轴相对于前板可动布置并支承注射螺杆的可动板；一布置在与所述前板相对位置上的后板，可动板布置在它们之间。

Our results have shown that the analgesic effect of morphine administered to nucleus accumbens was blocked by intra-habenula injection of naloxone or ME antiserum, whereas the analgesic effect of morphine injected into habenula was attenuated by intra-PAG administration of naloxone or muscimol, and enhanced by bicuculline methochoride (BMC, an antagonist of GABA receptor).

本工作实验结果表明，在伏核内注射吗啡产生的镇痛作用可被缰核内注射NX或ME抗体所大部阻断，而缰核内注射吗啡产生的镇痛作用又可被PAG内注射NX或γ-氨基丁酸受体激动剂异鹅羔胺所削弱，被GABA受体阻断剂氯甲基荷包牡丹碱所增强。

Mg/ kg way partially inhibited by L- NAME,or by sodium orthovanadate(50 ug/ kg),a potent inhibitor of protein tyrosine phosphatase;(2)genistein also decreased the PP of renal vascular bed in a dose-dependent manner and the effect of genistein was completely inhibiteby pretreatment with sodium orthovanadate,but unaffected by L- NAME;and(3 genistein decreased the PP of mesenteric vascula bed in a dose-dependent manner,an effect which was partially inhibited by sodium orthovanadate,but unaffected by L- NAME .

mg/ kg引起的效应；(2)向肾血管灌注环路中直接注射GST也可剂量依赖性地降低肾动脉的灌流压，预先注射正钒酸钠可完全抑制GST引起的效应，而L- NAME对此效应没有影响；(3)肠系膜血管灌流环路中注射GST可剂量依赖性地降低其灌流压，这一效应可被正钒酸钠部分抑制，而L- NAME对此无影响。

Furthermore, with only a half -dose of DNA in the current system, by the horizontal system under×100 magnification both the survival rate of pronuclear embryos following microinjection and the integration frequency of exogenous DNA injected into embryos also increased.

此外，利用该系统还可在低倍镜下×100）将DNA常规注射量减半注射，提高了原核胚注射后的成活率，其注射胚的外源基因整合率亦明显提高。

RESULTS: Administration of the soman (60 μg·kg-1, sc) led to a rapid reduction in body temperature. Administration of scopolamine (1 mg·kg-1, ip) markedly blocked the hypothermic effect of soman but administration of methyl scopolamine (1 mg·kg-1,ip) had no effect on the hypothermia.

结果： 皮下注射梭曼(60 μg*kg-1)后可引起体温快速的降低，腹腔注射东莨菪碱(1 mg*kg-1)可明显阻断梭曼的降温作用，注射甲基东莨菪碱(1 mg*kg-1)对其降温作用无明显影响。

The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.

本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法，研究丘脑网状核(nucleus reticularis thalami，RT)中γ-氨基丁酸(gamma-amino butyric acid ，GABA)能神经元、一氧化氮(nitrogen monoxidum，NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate，cAMP)及中缝背核(nucleus raphes dorsalis，DRN)至RT的5-羟色胺(5-hydroxytryptamine，5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP，5μg)，注射当天睡眠时间略有减少，第二日睡眠时间显著减少，觉醒时间明显增多，第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后，与生理盐水组比较，睡眠时间增加，觉醒时间减少；而RT内微量注射L-谷氨酸(glutamic acid， L-Glu， 0.2μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline，BIC，1.0μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen，BAC，1.0μg)后，产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg，0.5μg)后，与生理盐水组对比，睡眠时间略有减少，但无显著性意义；而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside，SNP，0.2μg)后可明显增加觉醒时间，缩短睡眠时间；微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine，L-NNA，2.0μg)后，引起睡眠时间增多，觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用；RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后，与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠，其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate，MOR，1.0μg)后与生理盐水组对比，睡眠时间减少而觉醒时间增加； RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride，NAL，1.0μg)后与生理盐水组比较，睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后，与生理盐水组对比，原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较，睡眠时间增多而觉醒时间减少；RT内微量注射亚甲蓝(methylene blue，MB，1.0μg)后，与NS组比较，睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 0.2μg)比较，睡眠时间减少，觉醒时间增多；大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射二甲基麦角新碱(methysergide， MS， 1.0μg )后，与对照组(DRN注射L-Glu 0.2μg，双侧RT注射NS 1.0μg)比较，睡眠时间增多，觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine，PCPA，10μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 1.0μg)比较，睡眠时间增多，觉醒时间减少；大鼠DRN内微量注射PCPA(10μg)，产生睡眠增多效应后，在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan ， 5-HTP， 1.0μg )后，与对照组(DRN注射PCPA 10μg，双侧RT注射NS 1.0μg)比较，睡眠时间减少，觉醒时间增多。

By adopting mechanical driving mode, the machine can be used for perform injection with stable pressure on bone pork, beef and poultry. When the injection needle contacts the bone, the downward movement is stopped by the pneumatic spring to protect the needle. The air chamber pressure of pneumatic spring is adjustable in order to ensure no damage on the bone.

用途采用机械驱动方式可对猪肉、牛肉及禽肉等带骨肉以稳定的压力注射，注射针在遇到骨头等硬物后可自动在气弹簧的作用下停止向下运行，保护注射针，气弹簧的气室压力可调节，保证对原料中骨结构不破坏。

Results as below:(1) serious swelling and plasma extravasation was evoked by an injection of mustard oil to a hind paw with a pre-injection of normal saline,(2) a pre-injection of BOTOX of 5 U, Lidocaine, or L-733060, all could effectively reduce the inflammation,(3) a BOTOX pre-injection of 5 U commenced to act at 7 days after the injection with a duration for at least 10 days.

实验结果如下：(1)芥末油注射於预先注射生理食盐水之后脚掌引起严重的肿胀及血浆外渗；(2)预先注射5 U之BOTOX、 Lidocaine或L-733060 可有效减低发炎反应；(3) 5U BOTOX在注射7天后开始发挥效果，此一效果维持至少十天。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。