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Experimental results show that rapid solidification technology can remarkably optimize Mg-Zn-Nd alloy's microstructure and property,there are three zones of fine grain zone,columnar grain zone and equiaxial grain zone in ribbon's solidification structure,which reserve structure character of cast-magnesium alloy.

结果表明:快速凝固技术可显著优化Mg-Zn-Nd合金的组织结构与性能;薄带的凝固组织分为细晶区、柱状晶区、等轴晶区三个区域,保留了铸态凝固组织的特性;快速凝固技术的细晶强化和固溶强化可明显改善Mg-Zn-Nd合金的强度与塑性。

These results suggested that 30 d HDT bed rest has induced significant reduction in heart systole function and heart pump function. The limb muscular exercise and the bicycle ergometric exercise to some extent can improve the heart systole function; however, the bicycle ergometric exercise was better.

结果提示,30 d头低位卧床可引起心脏收缩泵血功能下降,下肢肌力训练和自行车功量计训练可在一定程度上改善心脏收缩功能,其中自行车功量计训练的对抗效果更佳。

The cardiac systole and pump functions decrease significantly during 30 d HDT bed rest. The limb muscular exercise and the bicycle ergometric exercise may improve the cardiovascular system to some extent. Further, the bicycle ergometric exercise is the better one.

30 d头低位卧床可引起心脏收缩泵血功能下降,下肢肌力训练和自行车功率计训练可在一定程度上改善心血管功能,其中自行车功率计训练的对抗效果更佳。

Transplantation of BMSCs in neonate rats at 24 hours after HIBD has the maximal long-lasting ethological improvement, which is induced by brain damage, and the mechanism may be that early transplantation with BMSCs reduces effectively neuron necrosis and apoptosis, and is helpful for the migration and differentiation of BMSCs.

新生大鼠缺氧缺血性脑损伤后24 h接受骨髓基质细胞移植可最大程度改善脑损伤所导致的远期行为学障碍,其机制可能与早期移植可有效减轻神经元的坏死、凋亡,且有利于骨髓基质细胞的迁移、分化有关。关键词:骨髓基质细胞;细胞移植;缺氧;缺血;脑;新生大鼠

For a tested alloy containing 0.16 wt% RE, the shape recovery rate achieves 80% in water-quenched state and almost 100% after two cycles of training with a 4% prestrain. However, further more amount of RE addition may cause the formation of coarse, irregularly shaped and inhomogeneously distributed second phase particles in the alloys, resulting in a dramatic degradation in SME.

结果表明:在Fe-25Mn-6Si-5Cr合金中加入微量的稀土元素(0.032-0.20wt%)可以显著改善合金的形状记忆效应:特别是稀土含量为0.16wt%时,在预拉伸为4%的情况下,水淬状态下其恢复率可达80%,经两次训练后形状恢复率可接近100%。

CaN Aβ gene silencing can reduce myocardial hypertrophy in cultured cells, si1280 (21bp) of CaN Aβ gene is the most effective target site for siRNA. The method of intrapericardial injection of plasmid, microbubbles and erzymes can improve transfection efficiency of non-viral plasmid with satisfying targeted transfection. But the scope of transfected myocytes is still limited. CaN Aβ shRNA expressing plasmid transfection in vivo by pericardial injection results in decreased CaN Aβ protein expression of small part of myocytes, and CaN Aβ mRNA only shows decreased trend. The dosage of non-viral vector and the parameters of ultrasound energy should be optimized in further study.

结论RNAi技术抑制CaN Aβ基因表达可有效减轻Ald诱导的心肌细胞肥大程度;CaN Aβ基因中si1280(21bp)片段为实现RNAi的更有效片段;微泡+酶类心包腔内注射超声导入的方法可有效改善非病毒载体在体心肌的转染效率,同时具有一定的靶向性,但总的转染范围仍然有限;采用这一方法进一步进行&一肾一夹&心肌肥大模型大鼠在体心肌细胞的CaNAβ的RNAi干预,发现心肌肥大大鼠心外膜下局部心肌细胞CaN Aβ蛋白水平降低,CaN AβmRNA水平虽有下降趋势,但无统计学差异,提示质粒的用量及超声导入的参数有待进一步研究使其优化。

Resu1ts:0ur exprimemts manifest NtaC can prominently regu1ate1 ipid metabo1 ism, improve condition of hemorrheo1ogy, maintain homosta-sis of TXfu/6--keto--PGF,. l resist oxidation, lower liver index, reducethickness and stage of atherosclerosis p1aque, and promote remembrancefunct ion.

结果:脑力康胶囊可显著地调节血脂、改善血液流变性、维持TXB2与6-keto-PGF10的平衡、抗氧化、降低主动脉脂质含量、降低肝脏系数、病理学观察可减轻动脉粥样硬化程度、减少斑块厚度,且有促智作用。

The application of low pressure boiling technique could increase wort boiling temperature to 100.5 ℃ and advance protein agglomeration and reduce solidifiable nitrogen content to 0.5 mg/100 mL. Maillard reaction and Brown reaction were strengthened in the boiling, melanoidin and melanoid compound contents increased, wort chromaticity improved, and the oxidation resistance of wort strengthened. Besides, the boiling intensity dropped from 9 %~12 % to 7 %~8 % and boiling time shortened to 10~20 min, which improved production efficiency and saved 20 % energy and improved beer non-biological stability.

采用低压煮沸工艺,可提高煮沸麦汁温度至100.5 ℃,加强蛋白质凝聚,麦汁可凝固氮下降0.5 mg/100 mL;煮沸过程加强了美拉德反应、&棕色反应&,类黑精、类黑素化合物增加,麦汁色度增加,麦汁的抗氧化能力增强;煮沸强度从9 %~12 %降至7 %~8 %,煮沸时间缩短10~20 min,提高生产效率,节约能源20 %;改善啤酒非生物稳定性。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果:(1)FSN有明显的抗炎作用,可显著抑制AA大鼠足跖肿胀与多关节炎,改善大鼠的全身情况,同时明显减轻病变关节滑膜炎症与增生,防止关节软骨及骨质的破坏,其综合作用优于TWP;(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常,纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱,抑制大鼠PHφ过高的TNF-α、IL-1分泌,而发挥抗炎和免疫调节作用;(3)在病变关节局部,FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达,降低滑膜组织中NF-kB表达,并增加凋亡蛋白酶Caspase-3表达,从而抑制滑膜的炎症与增殖;(4)FSN还可下调滑膜组织中VEGF表达,减少血管新生,由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀;(5)FSN的上述作用皆呈现一定的量效依赖关系,高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果:(1)FSN有明显的抗炎作用,可显著抑制AA大鼠足跖肿胀与多关节炎,改善大鼠的全身情况,同时明显减轻病变关节滑膜炎症与增生,防止关节软骨及骨质的破坏,其综合作用优于TWP;(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常,纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱,抑制大鼠PMφ过高的TNF-α、IL-1分泌,而发挥抗炎和免疫调节作用;(3)在病变关节局部,FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达,降低滑膜组织中NF-kB表达,并增加凋亡蛋白酶Caspase-3表达,从而抑制滑膜的炎症与增殖;(4)FSN还可下调滑膜组织中VEGF表达,减少血管新生,由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀;(5)FSN的上述作用皆呈现一定的量效依赖关系,高剂量组作用优于低剂量组。

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