可抑制的

In this study, as a original strain, antagonistic bacterium Ata28 was mutated by UV, UV+LiCl, DES and Microwave irradiation; the very goal of the research is to improve the control efficiency of Ata28 strain against tobacco brown spot and obtain strains advanced both in antagonism and biological characteristics, further provides theoretics and practical experience to the production.

采用紫外线和氯化锂复合诱变Ata28菌株，通过预备实验，计算Ata28菌株在不同诱变时间的致死率和正变率，选择该菌株的最佳诱变时间10s，15s诱变；通过平板对峙培养，筛选出8个突变菌株在PDA平板上可明显抑制Tbs3的生长，抑菌带高于出发菌株Ata28，抑菌带最大值达9.7mm；经温室控病初筛和复筛试验，获得了对烟草赤星病有较好防效的突变菌株Uv1-190、Uv1-199，烟苗经Uv1-190、Uv1-199菌液处理3d后，接种Tbs3的防治效果达51.3％、54.9％，比出发菌株Ata28的防治效果好。

Ata28 strain exhibited marked suppression of Tbs3 strain which is the pathogen of tobacco brown spot on PDA plates, and the Ata28 strain had the good control efficiency of tobacco brown spot.

采用紫外线诱变Ata28菌株时，通过预备实验，计算Ata28菌株在不同诱变时间的致死率和正变率，选择该菌株的最佳诱变时间10s，20s，30s诱变；通过平板对峙培养，筛选出15个突变菌株在PDA平板上可明显抑制Tos3的生长，抑菌带高于出发菌株Ata28，抑菌带最大值达9.4 mm；在温室控病中，获得了对烟草赤星病有较好防效的突变菌株Uv-126，烟苗经Uv-126菌液处理3d后接种Tos3的防治效果达52.2％，比出发菌株Ata28的防治效果好。

Ata28 strain was mutated by UV with the most optimum mutant time, including 10, 20, 30s, that was chosen by the trial tests, considering the lethality rate and positive mutation rate of Ata28; it was found that 15 mutant strains were shown antagonism against Tbs3 strain by antagonism test on PDA plate, inhibition zone of mutant strains exceeded the original strain Ata28, and the maximum of inhibition zone reached 9.4mm; the mutant strain Uv-126 was found most effective in tobacco brown spot control and a rate of efficiency control reached 52.2% on tobacco plants three days after bacteria spraying.

采用硫酸二已酯诱变Ata28菌株，通过预备实验，计算Ata28菌株在不同诱变时间的致死率和正变率，选择该菌株的最佳诱变时间20min，40min，60min诱变；通过平板对峙培养，筛选出17个突变菌株在PDA平板上可明显抑制Tbs3的生长，抑菌带高于出发菌株Am28，抑菌带最大值达10.5 mm；经温室控病初筛和复筛试验，获得了对烟草赤星病有较好防效的突变菌株Des-66、Des-50，烟苗经Des-66、Des-50菌液处理3d后，接种Tbs3的防治效果达52.0％、56.6％，比出发菌株Ata28的防治效果好。

Now, research replaces the option of index in the various disease appraisement of curative effect to discuss , if with blood plasma 羟 hydrogen can appraise when ketone density is replacing index A flat kind ease pain medicine Kong Shi dose relieve pain effect , is taking ATT( aim at the antibody effect of tetanus toxin) as replacing index to appraise the immunity inhibition researchs of? single clone antibody 5c 8 of the CD 154 in monkey body to get better effect.

目前，已有研究就多种疾病疗效评价中替代指标的选择进行了探讨，如以血浆羟氢可待酮浓度作为替代指标评价阿片类镇痛药控释剂的止痛效果、以 ATT(针对破伤风毒素的抗体效应)作为替代指标评价猴体内 CD154的单克隆抗体5c 8的免疫抑制作用等研究都取得了较好的效果。

In a recent study, berry extracts slowed the growth of cancer cells; specifically, strawberry and black raspberry extracts had the greatest impact on colon cancer cells.

在最近的研究中，浆果中的提取物可减缓癌细胞的生长，特别是草莓和黑树莓中的提取物对抑制结肠癌细胞的效果最大。

Results:Osteoblasts has the ability of transmembrane transport of metformin. The transport of metformin could be saturable with time and drug concentration adding;a certain range of temperature and pH can promote the transport of metformin;The transport of metformin was inhibited by cimetidine and phenformin,but promoted by verapamil;Oct1 but no Oct2 was expressed extensively in cell membrane and cytoplasm of osteoblasts;The protein level of Oct1 can be up-regulated by metformin with different drug concentrations and times,but no obvious differentces from each group.

结果：二甲双胍能够在成骨细胞上进行跨膜转运，且随着转运时间和药物浓度的增加而增加，并可达到饱和；一定范围内提高温度和pH值可以促进二甲双胍的转运；西米替丁和苯乙双胍对二甲双胍转运有明显抑制作用，而维拉帕米则对转运有明显的促进作用；Oct1广泛表达在成骨细胞的胞膜及胞浆中，而Oct2无表达；二甲双胍在不同浓度及不同给药时间均能够上调Oct1的表达，但各组间无明显差别。

RESULT: In vitro,the IC_(50) of Que of inhibiting the production of lipid peroxides in homogenates from rat heart,brain,and CCl_(4) damaged liver in mice and H_(2)O_(2) induced hemolysis is 0.4×10~(-4),0.2×10~(-4),0.5×10~(-4),0.3×10~(-4) mol/L,separately,while that of TP is 0.7×10~(-4),7.8×10~(-4),1.1×10~(-4),0.6×10~(-4) mol/L,separately.

结果 ：在体外，Que和TP均可剂量依赖性地抑制Fenton反应导致的大鼠心、脑匀浆和CCl4毒化小鼠肝匀浆中过氧化脂质的生成和H2 O2 诱导的红细胞溶血：Que的IC50 分别为：0 4× 10 -4，0 2× 10 -4，0 5× 10 -4，0 3× 10 -4mol/L ；TP的IC50 分别为：0 7× 10 -4，7 8× 10 -4，1 1×10 -4，0 6× 10 -4mol/L。

Pantaleo G,Graziosic,Demarest JF,et al.HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease［J］.Nature,1993,362:355～360［5］Moss PAH,Rowland-Jones S,Frodsham PM,et al.Persistent high frequency of human immunodeficiency virus-specific cytolytic T cell in peripheral blood of infected donors［J］.Proc Natl Acad Sci USA,1995,92:5773～5777

一些研究显示在无免疫肌肉大夫压力下体外传代HIV的状况类似体内免疫肌肉系统全面崩溃的感染血液末期的状况：HIV变异株相对少，株间变异小，但毒力强、复制快、病毒痔疮产量高，可形成多核巨细胞疑难等等；HIV在适应了体外培养的环境和宿主细胞疑难、失去了选择大夫压力后，少数变异株在传代过程中经逐步稀释后逃脱优势株的抑制逐渐被固定下来而成为新的优势株［7］。

Pantaleo G,Graziosic,Demarest JF,et al.HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease［J］.Nature,1993,362:355～360［5］Moss PAH,Rowland-Jones S,Frodsham PM,et al.Persistent high frequency of human immunodeficiency virus-specific cytolytic T cell in peripheral blood of infected donors［J］.Proc Natl Acad Sci USA,1995,92:5773～5777

一些研究显示在无免疫压力下体外传代HIV的状况类似体内免疫系统全面崩溃的感染末期的状况：HIV变异株相对少，株间变异小，但毒力强、复制快、病毒产量高，可形成多核巨细胞等等；HIV在适应了体外培养的环境和宿主细胞、失去了选择压力后，少数变异株在传代过程中经逐步稀释后逃脱优势株的抑制逐渐被固定下来而成为新的优势株［7］。

The maximum MTG activity in the culture broth was 5.04u/mL and increased by 21.8% compared with the control. With the addition of CTAB, pro-MTG was activated to become MTG. CTAB could enhance the production of pro-MTG by relieving the pr...

初步研究表明，CTAB的主要作用是促使谷氨酰胺转胺酶的酶原转化为成熟酶，因此，在发酵过程中添加适当浓度的CTAB，可使酶原快速、完全地转化为成熟的MTG，解除酶原的产物抑制作用，促进了细胞产酶。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐