可抑制的

In addition, it must also evade immune clearance. Elimination of H. pylori by phagocytes is inefficient because H. pylori exhibits several virulence factors to evade opsonization, retard phagocytosis, and disrupt membrane trafficking and phagosome maturation after internalization of the microorganism.

为了增加存活与持续的依附在宿主体内，幽门螺旋杆菌发展出一些策略来抵御被免疫清除的命运，它可影响吞噬细胞的功能，包括避免受调理作用、抑制吞噬细胞的吞噬作用、影响细胞内的运输作用与吞噬小体的成熟。

The results showed that HGF not influenced the proliferation and osteogenic differentiation of bone marrow-derived mesenchymal stem cells.

结果表明，重组人HGF不影响骨髓间充质干细胞的增殖和向成骨细胞的分化，但可明显促进骨髓间充质干细胞的迁移并抑制anoikis诱导的细胞凋亡；PI-3K和MAPK途径参与了HGF促进细胞迁移的作用。

Result 1. CDK4, P16 were expressed in parabasal layers and the upper layer, mainly in the prickle and granular layers of cholesteatoma epithelium. Their positive rates were 68.6% and 88.6% respectively. Statistical analysis showed that there was a significant difference in positive rates between

CDK4与P16在中耳胆脂瘤上皮中均过度表达且有一定程度的正相关性，表明它们在疾病发生中是共同而非单独起作用的，从细胞周期的角度可反映胆脂瘤上皮细胞过度增殖的同时也增强负调控因子来抑制增殖，使凋亡同时加快而达到新的平

The induction effects of SO 2 inhalation on micronuclei formation in the polychromatophilic erythroblasts of mouse bone marrow and protection effect of Seabuckthorn seed oil were studied in vivo.

结果表明：(1)短期与长期 SO2 吸入均可引起小鼠骨髓 PCE细胞微核率和微核细胞率显著升高，且有明确的剂量-效应关系；(2 )随着吸入的 SO2 浓度的增高，不仅单微核细胞率，而且双微核细胞率均显著升高；(3) SO2对阳性致突变剂乌拉坦诱发微核的作用有显著抑制效应；(4 )沙棘油对 SO2 诱发 PCE微核的效应有防护作用。

During the treatment of skeletal Class ill malocclusion in mixed dentition, the reverse Twinblock could procline the upper incisor, accelerated the development of maxillary and mandibular ramus, and restrained the development of mandibular body. A randomly allocated prospective study was required to fully evaluate the bone efficacy of this appliance.

反向Twinblock矫治器可使上切牙唇倾、位置前移；在治疗期间能促进上颌骨的发育，抑制下颌体的发育，促进下颌升支的增高；反向Twinblock矫治器的对上下颌骨的长期作用有待进一步研究。

Chapter 2 discusses the function of optimum array based on the minimum meansquared error principle in CDMA system, the method of produce the reference signal, and proved whether the reference signal is the correspond PN code sequence or respread signal, the result of the array's weight converge can converge the same optimum weight under the condition that the PN sequence in a bit of data is long enough. In this chapter, we finally get the beam pattern and the correlate bit error rate after converge when several CDMA signal arrives in different direction.

本文的主要贡献及创新之处是：首次从理论上探讨了基于最小均方误差准则的最优天线阵在CDMA系统中的多址干扰抑制性能及其参考信号的产生方法，证明了采用有用信号相应的扩频码作为参考信号与采用将解扩信息与扩频码进行重扩频后的信号作为参考信号来调节自适应天线的权值均可使权值收敛于同一最优解。

Our data are showed that apoptosis parameters including DNA fragmentation, nuclear morphological change and sub-G1 fraction, appeared after 24 h by 5 μM rottlerin treatment. Furthermore, rottlerin caused a decrease in 72% of ODC protein expression and an increase in threonine, rather than serine and tyrosine dephosphorylation on ODC enzyme compared with the control after incubation for 10 h. To determine whether ODC could down-regulate rottlerin-induced apoptosis, HL60 cells were stably transfected with ODC cDNA. HL60-ODC cells exhibited a 2.5-fold increase in ODC protein compared with vector only (HL60-pcDNA3) or HL60 cells.

在我们筛选天然化合物实验中，发现rottlerin抑制鸟胺酸去羧化活性最具成效，之前的研究人员已知蛋白激Cd调节鸟胺酸去羧化的活性，因此在人类白血病HL60细胞处理rottlerin的实验中发现加入rottlerin二十四小时后，细胞进行计划性死亡，并可侦测到DNA片段、细胞核浓缩及sub-G1提增；而细胞处理药物十小时后与控制组细胞比较，观察到鸟胺酸去羧化的蛋白表现与活性下降50﹪以上；除此以外，测定鸟胺酸去羧化去磷酸化的情况，发现於酥胺酸位置有显著差异，而丝胺酸和酪胺酸位置并无差异。

The effects of many parameters, such as the amount of surfactant, airflow rates, pH, NaCl, ethanol and temperature on the solvent sublation were studied. Experimental results showed that a ratio of surfactant to Pb-dithizone complex (2∶1) was the most effective for the removal, with over 97.4% Pb removed from the aqueous solution in 40 min by solvent sublation, at the value of pH 12.6.The solvent sublation process followed first order kinetics. A characteristic parameter, apparent activation energy of attachment of the sublate to bubbles, was estimated at a value of 2.08 kJ/mol.

结果表明，当表面活性剂与硝酸铅物质的量之比为2∶1时，铅去除率达97.4％；体系去除率在pH值为12.6时最高；有机溶剂的影响不明显；少量的乙醇可提高其去除率和去除速率，但过多会产生抑制作用；适量的NaCl能提高体系去除率，但随着浓度的提高呈现下降趋势；去除速率随气流速率增加而增加，体系去除率随温度升高而递增；反应过程遵从一级动力学，表观活化能为2.08 kJ/mol。

Based on the fact that aminoacyl-tRNA synthetase is a bona fide drug target for several microorganisms, including bacteria and fungi, it is plausible that it may also be effective target of Trypanosoma. In this report, the Trypanosoma brucei Leucyl-tRNA synthetase was cloned , expressed and purified to develop an in vitro enzymatic assay system.

根据亮氨酰tRNA合成酶在微生物中可作为药物靶点的事实，在新型抗锥虫药物筛选中，通过对锥虫的亮氨酰tRNA合成酶的克隆、表达和纯化，以及该酶活性测定的优化，建立了该酶抑制物的筛选系统。

RESULTS:Our results indicate that the chemokine CCL5 can induce migration in humanbreast carcinoma cell line MCF-7 in vitro and suggest a potential role for Ezrin in theprocesses of breast cancer cell migration,invasion and possibly metastasis responsed toCCL5.We demonstrate that Ezrin siRNA specifically inhibits Ezrin expression of MCF-7cells and deregulates several functions such as cell motility and cell invasion,indicatingthat Ezrin plays a key role in the development of human breast cancer cells.It\'s suggestedthat Ezrin may act as a new anti-invasion therapeutic target for human breast cancer.

趋化因子CCL5促进人乳腺癌细胞MCF-7的趋化与侵袭，Ezrin蛋白的激活在此过程中起着重要的作用；成功构建Ezrin特异性siRNA表达载体，可用于探讨乳腺癌的侵袭转移机制，并为有效地抑制肿瘤的转移提供新的生物治疗靶点。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐