可抑制的

Abrin is one of the potent toxins isolated from the beans of plant abrus precatorius.the toxic protein consists of two disulfide-bonded subunits,the a and b chains.the b chain is a galactose-specific lectin that facilitates the binding of abrin to the cell membrane that precedes endocytosis.after entering the cells,the a chain catalytically inactivates 60s ribosomal subunits by removing adenine position 4324 of 28s r–rna,and thereby inhibits protein biosynthesis.

相思子毒素是从豆科植物(abrus precatorius l。)种子中分离的一种细胞毒性蛋白。它由a，b两条链组成，由一个二硫键相联，b链具有半乳糖凝集活性，可与细胞膜上受体结合，帮助a链进入细胞内，a链进入细胞催化失活60s核糖体亚基，从而使细胞蛋白合成被抑制。

The mechanism by which this occurs may be through competitive inhibition of the acetylation site of cyclooxygenase in the platelet.

这一制度出现的，可通过竞争性抑制乙酰网站化酶与血小板。

This can be contrasted with Lupus anticoagulant which inhibits agglutination in the presence of thrombin.

这可对比性狼疮抗凝抑制凝集，在场的凝血酶。

Inhibition of the pathway was reversed by enforced alkalinization or overexpression of NHE-1, leading to a restoration of apoptosis.

高度碱化或NHE-1 过度表达引起细胞凋亡恢复可翻转对该途径的抑制作用。

Antithrombin can inhibit the activity of thrombin.

抗凝血酶能抑制凝血酶的活性，AT缺乏或低下可引起凝血酶灭活减少，凝血功能亢进。

They include the variation of the degradement velocity of different sample, the inhibition product of PCR, the amount of DNA extraction, quality of DNA and the heteroplasmy of some tissue. Correct sequencing, comparison of the result of forward and reverse primers sequencing should be done to rule out wrong signals, and prevent contamination. In addition to gene sequencing, low grade heteroplasmy could be dealt by Denaturing high performance liquid chromatography. Multiplex Ligation-dependent Probe Amplification. The analysis of mitochondrial HV Ⅰ, HV Ⅱ sequencing is able to identify the maternal sanguinity, then it could assist in the human identification. It also complements the genomic STR system in distribution of population, the origin of human, and analysis for fossil.

分析粒线体DNA时必须考虑各类检体腐败DNA降解速度之不同、PCR的抑制物质、DNA的萃取量及品质、特定组织的异质现象、萤光序列分析图及正、反向引子定序结果比对、排除杂讯干扰、防治污染等，除以基因定序外，低程度的异质现象也可用Denaturing high performance liquid chromatography、Multiplex Ligation-dependent Probe Amplification等方法分析，粒线体HV Ⅰ、HV Ⅱ碱基序列的分析可鉴别一个人的母系血缘关系、辅助人类身分鉴定，对於族群分布、人类起源探讨、远古检体的分析可作为辅助STR系统的利器。

CaN Aβ gene silencing can reduce myocardial hypertrophy in cultured cells, si1280 (21bp) of CaN Aβ gene is the most effective target site for siRNA. The method of intrapericardial injection of plasmid, microbubbles and erzymes can improve transfection efficiency of non-viral plasmid with satisfying targeted transfection. But the scope of transfected myocytes is still limited. CaN Aβ shRNA expressing plasmid transfection in vivo by pericardial injection results in decreased CaN Aβ protein expression of small part of myocytes, and CaN Aβ mRNA only shows decreased trend. The dosage of non-viral vector and the parameters of ultrasound energy should be optimized in further study.

结论RNAi技术抑制CaN Aβ基因表达可有效减轻Ald诱导的心肌细胞肥大程度；CaN Aβ基因中si1280(21bp)片段为实现RNAi的更有效片段；微泡+酶类心包腔内注射超声导入的方法可有效改善非病毒载体在体心肌的转染效率，同时具有一定的靶向性，但总的转染范围仍然有限；采用这一方法进一步进行&一肾一夹&心肌肥大模型大鼠在体心肌细胞的CaNAβ的RNAi干预，发现心肌肥大大鼠心外膜下局部心肌细胞CaN Aβ蛋白水平降低，CaN AβmRNA水平虽有下降趋势，但无统计学差异，提示质粒的用量及超声导入的参数有待进一步研究使其优化。

Most patients' death arise from the metastatic spread of primary tumors There is an urgent need for the finding of novel anti-tumor and anti–metastatic drugs to improve the quality of life and survival rate of patents Justicia procumbens is an herb and used to reduce fever inflammation and canker in Taiwan We've detected that 0 3 μM JA could effectively inhibit the proliferation of oral cancer cells OC-2 and HSC3 but not normal oral keratinocytes in MTS assay JA-treated OC2 underwent apoptosis as suggested by increased sub-G1 DNA contents condensed nuclear morphologh and DNA fragmentiation The migration activity of OC-2 was also significantly reduced by treatment with low concentration of JA The expression of ?

大部分的口腔癌病患死於原位癌的转移和扩散，寻找有效抗癌和抗转移的药物疗法来增进病患的生活品质和存活率，对治疗口腔癌而言非常重要。爵床草是台湾民间常用草药，常被用来消炎止热和治疗口疮、乳瘤。我们利用MTS分析，发现处以0 3 μM的JA 48小时，即可有效抑制口腔癌细胞OC-2和HSC3的增生，但不影响正常口腔上皮细胞生长。OC-2经JA处理后，其sub-G1的DNA含量增加，并可观察到DNA固缩和梯度断裂的现象，说明JA可使OC-2走向细胞凋亡。除此之外，0 3 μM的JA亦可有效降低OC-2的迁移能力。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Said invented door plank storable and superposable screen window has left and right storage boxes for holding the screen roller made up by rolling up screen, and comprises latch hook, coupling bar, upper and lower guideways, the left and right storage boxes are freely fixed on the upper and lower guideways, according to the requirements the left and right storage boxes can be slided, and can be formed into square frame together with upper and lower guideways, and the screen can be spread and laid on said square frame so as to form the invented door plank storable and superposable screen window.

通过把抑制由纱网卷绕收藏成纱网滚筒的左右的收藏箱及纱网的上下端边固持的纱网往面内外方向弯曲的挂钩装成相对于上、下导轨自由滑动，而且将在左右的收藏箱装成自由滑动的连动杆设置为和该上、下导轨的卡合孔自由卡合，将左右的收藏箱自由固定于上、下导轨，按照需要使左右的收藏箱滑动，和上、下导轨一起形成方形框，而且借着在自收藏于左右的收藏箱内的纱网滚筒拉开纱网下展开、铺设成该方形框，可形成门板状可收叠纱窗。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。