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Flow cytometry results showed that: 1) When cells were treated with Diallyl trisulfide at the concentration of 10 μg/mL for 12 h and 24 h the percentage of G0/G1 phase cells was decreased and that of G2/M phase cells was significantly increased compared with those in the control group.2) Diallyl trisulfide down regulated Bcl expression while up-regulated bax expression.

结果:MTT显示大蒜素能抑制人结肠癌 HT29细胞的增殖,并具有时间-剂量依赖性;流式细胞术测定结果显示10 μg/ml大蒜素可明显诱导HT29细胞凋亡,并将细胞周期阻滞在G2/M期;可降低癌基因蛋白Bcl表达,而促进Bax表达。

Compared with control,①the mean tumor weight of H22 of SXKA Granules three dose groups were decreased significantly(P.01,P.05),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 30%;②the mean tumor weight of S180 of SXKA Granules three dose groups were decreased significantly(P.01),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 32%;③the mean tumor weight of EAC of SXKA Granules three dose groups were decreased significantly ( P.01, P.05),and the mean inhibition rates of SXKA Granules 20 g/kg dose groups were above 38%;④the mean tumor weight of Lewis carcinoma of SXKA Granules three dose groups were decreased significantly(P.01, P.05),and the mean inhibition rates of SXKA Granules 20、10、5 g/kg dose groups were above 36%;⑤the mean tumor weight of W256 of SXKA Granules three dose groups were decreased significantly ( P.01, P.05),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 32%;⑵Compared with control,SXKA Granules 20、10 g/kg dose groups had extended the survial time of the P388-bearing mice respectively(P.01),and the mean prolong rates of SXKA Granules 20、10 g/kg dose groups were above 50%;⑶Compared with S180-bearing group, SXKA Granules 20、10 g/kg dose groups could increase the weight of thymus and spleen, Spleen index and thymus index were increased, SXKA Granules 5 g/kg dose group could increase thymus index(P.05);⑷As Compared with control group, SXKA Granules 20、10 g/kg dose groups could improve mouse serum half hemolysis value depressed by transplanted tumor dramatically(P.01), which revealed the SXKA granules could improve the mouse humoral immunity system;⑸SXKA Granules 20 g/kg dose group could increase of englobe indexαon S180-bearing mice remarkably(P.01), which indicated the SXKA Granules could improve their cellular immunity system.

对荷W256大鼠,生兴克癌冲剂20、10、5 g / kg三组的平均瘤重明显低于对照组(P.01,P.05),生兴克癌冲剂20、10 g / kg组的平均肿瘤抑制率均大于32 %;⑵与空白对照组相比,生兴克癌冲剂20、10 g/ kg能显著地延长移植小鼠白血病P388小鼠的存活天数(P.01),生兴克癌冲剂20、10 g/ kg对荷白血病P388小鼠生命延长率均在50%以上;⑶与S180荷瘤组相比,生兴克癌冲剂对荷瘤鼠的免疫器官重量、胸腺指数和脾指数有一定的提高趋势,其中生兴克癌冲剂5 g / kg组对荷瘤小鼠的胸腺指数有一定的提高作用(P.05);⑷与S180荷瘤组相比,生兴克癌冲剂20、10 g /kg组可提高由荷瘤引起的小鼠血清半数溶血素值的降低(P.01),表明其可提高荷瘤小鼠体液免疫功能;⑸与对照组相比,生兴克癌冲剂20 g /kg组可提高荷S180肉瘤小鼠的免疫吞噬系数α值(P.01),表明其可提高荷瘤小鼠细胞免疫功能。

In pure cultured neuron, the inhibitory effect of 0.5mmol/L L-NNA on theincrease of LDH leaking after exposure of H/R and SIN-1 had also no statistical significance, but it could inhibit significantly the above index in mixedly cultured cerebral cortex neuron and glia.

在单纯培养神经细胞中0.5mmol/LL-NNA对H/R+SIN-1导致的LDH漏出率增加仍无显著抑制作用,但可显著抑制H/R引起的混合培养的神经细胞和神经胶质细胞的LDH漏出率。

The SPECT imaging of ~(99)Tc~m-GEBP11 can show the tumor mass clearly and ~(131)I-GEBP11 has anti-tumor effect with weak toxicant and secondary effect, which is the foundation for them to develop nuclide probe or radiotherapeutics drugs targeting to tumor vasculature.3. GEBP11 can inhibit angiogenesis, which comes true probably through its inhibition effects on the proliferation, invasion, migration and adherence of ECs.

1、GEBP11具有活体内胃癌血管靶向结合的能力,它与胃癌血管内皮细胞膜受体特异结合后可被内化。2、~(99)Tc~m-GEBP11 SPECT成像能较好地显示体内肿瘤灶,~(131)I-GEBP11具有明显的抗肿瘤效应及较弱的毒副作用,为开发肿瘤血管成像核素探针及受体放射治疗新药奠定了基础。3、GEBP11具有抑制胃癌血管生成的作用,这可能通过抑制ECs增殖、基质降解及迁移、粘附能力实现。

Results The results showed that the material with the antibacterial activity in sapium root bark primarily was in the part of large polarity, but there was antibacterial activity in the material of the methanol elution with larger polarity; and the inhibitory components of the soluble material of ethyl acetate was complex and the different parts had the variable inhibition to different bacteria and in general these materials had a certain inhibition to Staphylococcus aureus and Escherichia coli.

结果]乌桕根抑菌活性物质主要存在极性较大的部分,但极性很大的甲醇洗脱部分也没有抑菌活性;乙酸乙酯可溶部抑菌成分较复杂,不同部分时不同细菌的抑制作用不同,总体来说对金黄色葡萄球菌和大肠杆菌有一定的抑制作用。

The characteristics of the thermostableα-amylase were also discussed. The optimal temperature and pH for the enzyme were determined as 95℃and 10.0 respectively.

通过对酶性质的研究可得知:酶的最适反应温度为95℃,最适酶作用pH10.0,适量浓度Ca2+在60℃~80℃的范围对酶活力有激活作用,在80℃以上对酶活力有抑制作用,过高浓度的Ca2+对酶活力有抑制作用。

Trial in vitro made clear that it could remarkably increase the contractile of sphincter urethrae , inhibite the urinary bladder smooth muscle contraction and lower the baseline; when the mixture of Suo Quan Gu Niao was 25mg /ml, it could inhibit the urinary bladder strip contraction induced by KCL,too.

离体实验发现,缩泉固尿合剂在25mg/ml时能显著增强家兔尿道括约肌收缩力,并能抑制膀胱平滑肌的自动节律性收缩,同时可使平滑肌松弛,基础张力降低;对KCL引起的离体膀胱平滑肌的收缩具有一定的抑制作用。

When the mevinphos was utilized for a long time in highland barley field, the young-root of next-season cole shortened 1.9~2.0cm and fresh weight decreased 0.13~0.14g per individual plant compared with the control. Low-tillage in time after autumn-harvest showed that the weed seeds in the ground surface were harrowed into the tilth of 0~10cm. Early-low-tillage in spring-sow of the next year induced weed seeds of soil surface to germinate and come out ahead. After 10 days, tillage-sow can decrease about 40% weeds. Compared to the normal plough-row, direct late-tillage-row was postponed 10 days, and can decrease about 30% weeds. In the seedling period or later, rudimental weed seeds were handled with a hoe, which led to better cure and control effects and had more benefits to the young seedling growth and yield of the next-season crop.

研究结果表明:氟乐灵在油菜田长期使用时,土壤残留农药抑制下茬青稞幼根生长,幼根较对照株缩短3.0~3.1cm/株,鲜重量减少0.19~0.20g/株;甲磺隆在青稞田长期使用时,下茬油菜幼根较对照株缩短1.9~2.0cm/株,鲜重量减少0.13~0.14g/株;秋收后及时浅耕可将落入地表的杂草种子全耙入0~10cm耕层内;翌年春播早浅耕可诱发土壤表层的杂草种子提前萌发出苗,10d后耕种,能防除40%左右的杂草株数;较正常播种期推迟10d后直接晚耕播种,可防除30%左右杂草株数;苗期或后期拔出残余杂草种子时,除草效果理想,对下茬作物幼苗生长发育及产量无任何不良影响。

Telomerase activation is a key tumor marker which immortalizes cell.If a medicine blocks telomere prolonging by attenuation of telomerase activity, it could inhibit tumor cells proliferation.

因为端粒酶活化是大多数肿瘤细胞维持端粒长度并获得永生化的必要条件,如果某种药物能抑制端粒酶的活性就可阻断端粒的合成,从而使细胞退出增殖周期,达到抑制肿瘤细胞增殖的目的。

Greater than -10 mV and shows little inactivation during a 200 ms depolarization. It is completely reprimed at a holding potential of -60 mV, and can be isolated by using a more depolarized h.p.(-40 mV) to inactivate the other two types of calcium currents. 3. Component T can be seen in isolation with weak test pulses.

在测试电位大于-10mV时,L电流被产生并不会在200ms除极化的过程中被抑制。L电流在-60mV时被可被重新发起,并可在-40mV时以抑止其它两种钙离子电流被隔离。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。