可抑制的

However, COX-2 inhibitors generally induce liver injury and it is controvertible to applied COX-2 inhibitors in clinic therapy.

可COX-2抑制剂因易引发肝损伤的副作用，影响了COX-2抑制剂在临床上的应用。

Results: Shukang granule can obviously resist inflammation induced by dimethylbenzene, egg-white, raise the pain range of mice induced by hot plate , extend the delitescence of mice's turn-body reaction induced by injecting potassium antimony tartrate and decrease the number of times in 10min, restrain the meat-bud of rats formed.

结果：术康颗粒可明显抑制二甲苯所致小鼠耳廓肿胀和大鼠蛋清性足趾肿胀，明显提高小鼠热板法致痛的痛阈，使酒石酸锑钾所致小鼠扭体反应的潜伏期延长，10min内扭体次数减少，对大鼠棉球肉芽肿形成有抑制作用。

Results Laminarin exhibited a dosedependent inhibitory effect on the hydroxyl free radical and superoxide anion free radical.

结果 海带多糖体外可清除O-2·及·OH；抑制 H2O2 诱导的大鼠红细胞氧化性溶血；抑制小鼠组织MDA的生成。

The suitable inhibitive concentration was 0.5%. In Chinese-style sausage, Weeping forsythia can reduce the rate of lipid oxidation and rancidity during the periods of storage.

将连翘添加于中式香肠中，可有效抑制中式香肠贮存过程中的脂肪酸败，其抑制作用随连翘在中式香肠中浓度的提高而加强。

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

RT-PCR show an increase expression of mRNA of MMP-1, MMP-3 and IL-1β in OA synovia tissue in ovariectomized rabbits. Estrogen supplement could decrease the expression, an enhancement effect could observed with progestin.

RT-PCR法半定量检测结果发现，去势后兔膝OA滑膜组织中MMP-1、MMP-3和IL-1β mRNA表达增加，给予雌激素对三者的表达均有抑制作用，加用孕激素可使这一抑制作用增强。

Therelationship between the turbulent kinetic energy and its dissipation rate,whichis widely used to parameterize the dissipation rate in turbulence closure models,is found to hold well for both reversing and rotating flows,but with differentcoefficients.Microstructure profiling measurements at two comparative stations (a deepercentral basin and a local shelf break) in the stratified Yellow Sea are analyzed,with emphasis on tidal and internal-wave induced turbulence near the bottomand in the pyenocline.The water column has a distinct three-layer thermohaline structure,consisting of weakly stratified surface and bottom boundary layers anda narrow sharp pycnocline.Turbulence in the surface layer is controlled by thediurnal cycle of buoyancy flux and wind forcing at the sea surface.while thebottom stress induced by barotropic tidal eurrents dominates turbulence in thebottom boundary layer.The maximum level at which the tidally enhanced mixingcan affect generally depends on the magnitude of the tidal current,and it canbe up to 10-15 m in the Yellow Sea.This suggests that,in the deeper regionsof the shelf seas,turbulent dissipation and mixing are very weak at the levelsbetween the near-bottom tidally enhanced layer and the pycnocline.Therefore,these levels provide a significant bottle neck for the vertical exchanges.In theshallow regions,however,the tidally-induced turbulence can occupy the wholewater colum below the pycnocline.A quarter-diurnal periodicities of the turbulentdissipation rate and eddy diffusivity are found at different heights with evidenttime lag.In the relatively flat central basin,the pycnocline is essentially non-turbulent and internal-wave activity is very weak.Therefore,vertical fluxes acrossthe pycnocline decreased to molecular levels.In contrast,internal waves of variousperiods can be always found near the local shelf break.

对强层化季节黄海两对比性站位(分别位于中央海盆区与局地陆坡区)处层化、内波以及湍流混合特征的研究结果表明：1、强层化季节的陆架海水体一般呈现显著的三层热盐结构，在水体近乎混合均匀的上混合层与潮流底边界层之间为强跃层；2、近表层水体的湍流混合强度主要由海表浮力通量的日变化与海表风强迫控制，而在潮流底边界层内，潮混合是水体热量、物质、动量与能量垂直交换的主要机制；3、潮混合影响的深度由潮流大小决定，在黄海，一般可达10-15 m，因此，在水深较深的区域，在跃层与潮混合所至深度范围的上界之间存在湍流混合非常弱的区域，这显著抑制水体内物质的垂直通量，为物质垂直交换的瓶颈，而在水深较浅的区域，潮混合影响范围可至跃层底部，因此物质在跃层以下整个水体中混合非常均匀，当跃层内间歇性强混合发生时，可以产生显著的跨跃层物质输运；4、近底潮致强湍流耗散缓慢地向上传播，底上不同深度处垂直湍扩散系数也具有显著的位相差异，且二者均随时间呈现四分之一周日周期的变化；5、在地形较为平坦的中央海盆区，内波活动非常微弱，因此跃层内湍流混合非常弱，垂直扩散系数为分子扩散水平，跨跃层物质通量受到显著抑制，而在地形变化较为显著的局地陆坡区，内波活动非常活跃，除内潮的影响外，高频内波与内孤立波的影响也很显著，因此跃层内存在很强的间歇性强混合，内孤立波存在的区域，水体湍流混合显著增强。

The dynamic changes of the the neuron apoptosis and correlative genes in hippocampus of ACET-groups and twice-ACET-groups suggested that ACET can slower the apoptosis by inhibiting p~(53)and prolong the ascending period of p~(53) in 4 days after the seizure,this effect would weaken after 4 days.ACET may inhibit the descending of Bax,prolong its descending period and then promote its expression,in order to weaken the inhibition of the apoptosis during 4 to 10 days after seizure and then promote the apoptosis during 10 to 14 days after.This effect of ACET can be enhanced after treating again within 7 to 14 days later.

埋线组和二次埋线组大鼠海马神经元凋亡及相关基因表达的动态变化结果提示：埋线治疗在癫痫发作后的早期(4d内)可通过抑制促凋亡基因p~(53)蛋白表达、延缓其达峰值的时程，从而减缓神经元凋亡的发生，此作用在4d后减弱；埋线治疗抑制大鼠海马神经元凋亡的作用在癫痫发作后的中期(4d～10d)减弱，甚至在远期(10d～14d)出现促进凋亡的作用，可能是通过抑制Bax蛋白表达的下降、延长其降至低峰值的时程，促进Bax蛋白表达的回升的结果；在中远期(7d～14d)内予二次埋线治疗对该效应有续效叠加的作用。

The results indicated that:(1) 4 d or 6 d after denervation, increase of endocyto--sis and proliferation of satellite cells in denervated muscle were induced.(2) Actino--mycin D inhibited activation of satellite cells and endocytosis in normal muscle.

结果表明：(1)去神经4d或6d的肌肉可引起胞纳的增加和卫星细胞的增殖；(2)放线菌素D抑制正常肌肉的卫星细胞激活和胞纳作用；(3)在去神经的肌肉中，放线菌素D抑制了卫星细胞增殖的同时还抑制了胞纳的增加，但不能阻止去神经肌肉的萎缩。

Alcohol: CNS Depressants may enhance the CNS depressant effect of Alcohol.

酒精：CNS抑制剂可增强酒精的CNS抑制作用。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。