可抑制的

The colony forming and the cell cycle were analyzed with flow cytometry, and the mRNA expression of bcl-2, c-myc gene were determined with RT-PCR method. Results Resveratrol could markedly inhibit proliferation of human gastric cancer cells compared with that of the blank control group. The cell cycle was blocked to G0/G1. The mRNA level of bcl-2 and c-myc gene were decreased compared with that of the blank control group.

结果 白藜芦醇可抑制胃癌细胞增殖和集落形成能力，低、高剂量组的抑制率分别为6.9%，17.6%和27.98%，63.39%，差异均有统计学意义(P.05)；白藜芦醇能使胃癌细胞周期阻滞于G0/G1期，明显下调胃癌细胞bcl-2、c-myc基因mRNA表达水平(P.05)；用药24 h后，白藜芦醇高剂量组bcl-2和c-myc基因相对表达量分别为(0.54±0.04)，(0.58±0.05)，与空白对照组(0.91±0.05)，(0.85±0.03)比较，差异均有统计学意义(P.05)。

Among the bacterial isolated, B8 greatly inhibited rhizopus rot and brown rot, while Bw6 and Bw7 prevented brown rot and Bwl0 could also significantly inhibit rhizopus rot.

在分离的细菌中，B8对褐腐病和软腐病的抑制作用最好，Bw6和Bw7可抑制褐腐病的发生，Bwl0则对软腐病有显著的抑制作用。

ACE inhibitors, which are now widely used for the treatment of hypertension and heart failure, not only block the generation of Ang II from Ang I, but also prevent the degradation of bradykinin.

血管紧张素转换酶抑制剂现今被广泛应用于高血压和心脏病的治疗中，不仅可以抑制Ang I 到Ang II 的转化，同时还可抑制BK 的降解。

Processing with SCCO2 raises the content of LOX enzymes by 99% and inhibit trypsin activity responsible for off-flavors.

经过SCCO2处理的大豆可抑制胰蛋白酶抑制素。这些经过处理的豆类寿命在不进行冷冻的情况下可达到30天。

Radiolabeled pharmacological binding assay showed: 1 BmK AS bound specifically to a single class of non-interacting binding sites on both rat brain and cockroach nerve cord synaptosomes with high affinity and low low capacity. The association of BmK AS with both synaptosomes was quick to reach equilibrium, but the dissociation seemed to be only partial. The specific binding of BmK AS was independent of membrane potential, and couldn't be modified by veratridine. Moreover, the binding of BmK AS could be inhibited by native BmK AS, BmK AS1, BmK IT2 and BmK IT on both synaptosomes, but not or partially inhibited by BmK Ⅰ and suggesting BmK AS type neurotoxins might bind to a distinct receptor site on mammal and insect sodium channels with a similar manner from β-scorpion toxins.

二。蝎毒素多肽配体与哺乳动物和昆虫靶离子通道受体的药理结合特性及其靶结合位点的研究：经放射性标记结合和竞争抑制实验表明：1）BmK AS在大鼠脑和蟑螂神经索突触体上有单一非协同性高亲和力低结合容量结合位点，能快速结合并达到平衡，但仅能部分解离，其结合不依赖于膜电位，也不受藜芦碱调节，天然的BmK AS，BmK AS-1，BmK IT2和BmK IT可抑制〓AS与两种突触体的特异结合，而BmK Ⅰ无或仅有部分抑制效应。

It was demonstrated that the growth of glioma in rat can be inhibited by PCNA antisense oligonucleotides, the expression of PCNA target gene and prolification of glioma cells can be inhibited by PCNA antisense oligonucleotides.

PCNA反义寡核苷酸对胶质瘤的生长具有抑制作用，通过反义技术可抑制靶基因的表达，从而抑制胶质瘤细胞的增殖。

The expression of AT2R gene can be regulated efficiently in vivo by local delivery of MSC with dual-stable expression of AT2R gene, thus reduces the formation of intimal hyperplasia.④AT2R gene can influence the expression of ECM and significantly promote the cellular apoptosis in the injury rat carotid artery.⑤These data demonstrate the clinical potential of AT2R regulatable expression to prevent restenosis after PCI.

研究结论：(1)与VSMC直接接触可以诱导MSC向血管成分细胞分化；(2)构建的Dox-on可调控的MSC细胞株诱导活性可靠，使外源AT2R基因的表达处于有效的主动控制下；(3)局部导入MSC不影响球囊损伤后大鼠颈动脉新生内膜增生；(4)由MSC介导的AT2R可调控表达受到Dox的良好调控，可有效抑制球囊损伤后大鼠颈动脉新生内膜增生；(5)AT2R影响血管损伤后修复时ECM成分的表达，并促进细胞凋亡的发生，可能是AT2R介导抑制新生内膜形成的机制。

The EC_(50) of QKL against the formation of syncytia of MT-2 induced by HIV-1_ was 1/198.02 with a SI of 5.36. By detecting the survival rate of co-culturing H9/HIV-1_ cells and MT-2 cells or MT-2 cell direct infected by HIV-1_ QKL was found to be protective to cells. The EC_(50) was 1/166.67 and 1/144.93 with SI of 4.51 and 3.92 respectively. The EC_(50) of QKL against P24 antigen production was 1/175.44 with SI of 4.75. The drug serum of QKL was also found to be effective to inhibit the cell fusion and protect cells infected by HIV-1_.

结果：QKL对H9／HIV-1_细胞和MT-2细胞的CC_(50)分别为1／50.76和1／36.97；抑制H9／HIV-1_细胞和MT-2细胞早期融合的EC_(50)=1／235.29，SI=6.36；抑制HIV-1_细胞诱导MT-2细胞形成合胞体的EC_(50)=1／198.02，SI=5.36；H9／HIV-1_细胞和MT-2细胞混合培养和HIV-1_感染MT-2细胞时，QKL保护病毒感染细胞免于死亡的EC_(50)分别为1／166.67和1／144.93，SI分别为4.51和3.92；抑制p24抗原产生的EC_(50)=1／175.44，SI=4.75；QKL药物血清也可抑制H9／HIV-1_细胞和MT-2细胞的早期融合，保护细胞免于死亡。

Motilin and gastrin induced contraction of isolated gastric smooth muscle cells in a dose-dependent manner.(2) Motilin- and gastrin-induced antral smooth muscle cell contraction was inhibited by antibodies against Gαi-3. Motilin and gastrin caused an increase of Guanosine-5′-(3-［35S］thio)triphosphate(［35S］GTPγS) binding of Gαi-3.(3) Contraction of antral muscle cells induced by motilin and gastrin was inhibited by the phospholipase C inhibitor U-73122 and the IP3 receptor antagonist heparin.

结果显示：(1)胃动素和胃泌素对胃窦平滑肌细胞均有收缩作用；(2) Gαi-3抗体可抑制胃动素和胃泌素加强胃窦平滑肌细胞的收缩，胃动素、胃泌素明显增加Gαi-3抗体与［35S］GTPγS的结合；(3)磷脂酶C抑制剂U-73122、三磷酸肌醇受体拮抗剂肝素可抑制胃动素和胃泌素引起的胃窦平滑肌细胞的收缩。

In addition concentrated QC can also inhibit the growth of skin tumor caused by shope papilloma virus. But neither concentrated QC, nor D77 could inhibit the mouse skin tumors caused by chemical carcinogen and tumor promoter with initiation and promotion protocol.

另外中药QC膏剂还可抑制Sh〓乳头瘤病毒所致的兔乳头瘤；D〓腹腔注射时对S-180腹水瘤也有一定的抑制作用；但无论是中药QC膏剂，或D〓对化学致癌物3-甲基胆蒽与促癌物巴豆油合用诱生的小鼠皮肤瘤无抑制作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。