可抑制的

Cinerea were observed, and the inhibition rates could reach 100% at the concentration of 20μg/mL. The sclerotium formation, sclerotium form and distribution were influenced in different extent. C8-10 presented 90% inhibition rate on sporulation at the concentration of 40μg/mL. 1227 and C8-10 surfactants could obviously increase the permeability of cell membrane over the concentration of 20μg/mL.

两者对菌丝干重，孢子萌发均有较强的抑制作用，20μg/mL时抑制率接近或达到100%；对菌核数，菌核形态及分布有一定影响；40μg/mL C8-10对该菌产孢量的抑制率可达90%以上；1227和C8-10的浓度大于20μg/mL时均能明显影响病原菌细胞膜的通透性。

It indicated that the yield of tetraploidy not more than 25% induced by inhibiting the first mitosis with CB, colchicine and 6-DMAP, respectively, while it can be induced with higher percentage by blocking PB1releasing with CB. The tetraploidy percentage of groups shock began at 15—22min after fertilization are higher than that shock began at 42min, and the yield of tetraploidy also increased with the CB density and time lasting.

结果表明，CB、6-DMAP和秋水仙素抑制扇贝第一次卵裂诱发四倍体的比例低于25%；采用CB抑制PB1可有效地诱导产生四倍体，从授精后42min提前到15—22min开始处理，抑制PB1的放出有助于提高四倍体的比例，在12℃，处理开始和终止时间分别在授精后20—22min和62—67min时(即PB2始出现时)，面盘幼虫四倍体率最高，为56.5%。

It can protect cells from complement-mediated lysis and prevent the forming of anaphylatoxin (C3a and C5a), thus being a potential ideal drug that block complement activation for the treatment of several human diseaseas.

既可以抑制补体的溶破效应，更可阻止C3a、C5a等过敏毒素和趋化因子的产生，因而是一种潜在的理想的补体抑制药物，可用于防治多种疾病过程中补体系统的异常激活。

However it was shown its eventually inhibiting effect on apoptotic myocyte cells during I〓 R〓h (P＜0.05); The PKC inhibitors chelerythrine and scutellarein have no effect on expression of Fas protein, whereas they can significantly upregulate the expression of Bcl-2 protein.

4PKC激活剂PMA可下调Fas基因的蛋白表达，对Bcl-2蛋白的表达也有抑制作用，它对缺血30min、再灌注24h后心肌凋亡细胞的最终影响为抑制效应(P＜0.05)，而PKC抑制剂CHE、灯盏花素对Fas基因蛋白表达无明显干预影响，但对Bcl-2蛋白表达呈显著上调作用，故对心肌细胞凋亡的抑制作用更为明显(P＜0.01)。

A dose-dependent inhibition of cGMP-PDE activity was observed when cUMP 10~(-6-10~(12) M was added to the culture medium, which may explain the increase of the level of intracellular cGMP, while the activity of cAMP...

浓度为10~(-6)-10~(-12)McUMP对胞内cAMP-PDE活性几乎没有影响，而抑制cGMP-PDE的活性，抑制作用随cUMP浓度降低而减小，这可能是胞内cGMP水平增高的原因。cUMP可能与细胞的cAMP PK结合，释放催化亚单位，细胞生长的抑制可由此发生。

The HE activity was almost completely inhibited by SBTI, p-APMSF, bestatin and NEM, greatly inhibited by ovomucoid, TLCK, IAM, chymostatin and PMSF, and slightly inhibited by pepstatin A, TPCK, LBTI and leupeptin. And these results imply that HE is most probably a trypsin-type serine protease.

抑制剂对其酶活性的影响结果显示，该孵化酶的活性几乎可被SBTI、p-APMSF、Bestatin和NEM所完全抑制，被ovomucoid、TLCK、IAM、chymostatin和PMSF所强烈抑制，而对pepstatin A、TPCK、LBTI和leupeptin不敏感，表明该酶极可能是一种属于胰蛋白酶类型的丝氨酸蛋白酶。

IDO inhibits the proliferation of eukaryotic intracellular pathogens or tumor cells by depriving them of tryptophan. IDO has been targeted for neurological disorders: it causes decrease of serotonin level in the brain resulting depression, and it causes the accumulation of neurotoxic quinolinic acid. IDO plays a key role in the suppression of T cell response and antitumor immune, it induces immune tolerance to embryo and explant.

IDO可通过降低微环境中色氨酸的浓度而达到抑制病原微生物增殖的作用； IDO与神经系统疾病也密切相关，它能降低5-羟色胺的水平而导致抑郁，也可造成脑中喹啉酸等具有神经毒性的代谢产物的累积； IDO在抑制T细胞免疫和抗肿瘤免疫、诱导母胎免疫耐受和移植物免疫耐受中均发挥重要的代谢性免疫调节作用。

The treatment of leukemic cell with a longterm, intermittent,singular, unefficient chemotherapeutic agents could induce multi-drug resistant cells. Interleukin-4 can reverse the multi-drug resistance by inhibiting the expression of p-gp and increasing the quantity of intracellular chemotherapeutic agents in tumor cells. The effects were probably related to the inhibition of the PKC activity.

长期、间断、单一、不足量的化疗可导致 MDR；IL-4 可通过抑制肿瘤细胞的 p-gp表达，增加化疗药物在肿瘤细胞内的聚集而逆转白血病细胞的MDR，此作用可能与抑制 PKC的活性有关。

Cinnamomea, antrocamphin A was purified from previous ethanol extraction using bioactivity-guided fractionation. As results, the antrocamphin A could significantly inhibit NO and PGE2 autacoids production in LPS-induced RAW 264.7 macrophage cells. Meanwhile, the mRNA and protein expression levels of iNOS and COX-2 were inhibited by antrocamphin A in a dose-dependent manner. Antrocamphin A also reduced the translocation of NF-κB induced by LPS, which was associated with the prevention of the degradation of I-κB, and subsequently decreased p65/p50 proteins level in the nucleus. This is the first report demostrating the A.

接著并以活性为导向的分离策略，从樟芝子实体乙醇抽出物中分离出具抗发炎活性成分antrocamphin A，续利用LPS诱导小鼠巨噬细胞（RAW 264.7）产生发炎的模式，解析antrocamphin A之抗发炎机制，结果证实antrocamphin A确可有效抑制一氧化氮自由基和前列腺素的生成，透过蛋白质表现分析得知，antrocamphin A之抗发炎活性是经由抑制一氧化氮生成酵素和第二型环氧酵素的mRNA表现，进而抑制了一氧化氮生成酵素、第二型环氧酵素和核转录因子-κB等酵素之表现。

5-LOX participate in the formation of retinal neovascularization,Selective inhibition of 5-LOX can reduce the expression of VEGF and its receptor KDR, its specific mechanism may be associated with inhibition of ERKs signaling.

5-LOX参与视网膜新生血管的形成，通过对其选择性抑制可下调VEGF及受体KDR的表达从而抑制新生血管的生成，具体机制可能与抑制5-LOX激活MAPKs信号通路的外部ERKs有关。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。