可导致的

BSA can induce ACE up-regulation in proximal tubular cells, which may lead to the increased production of local AngⅡ and finally contributes to the intrarenal activation of renin angiotensin system.

BSA可显著增加HK-2细胞ACE表达，此作用可能是导致肾间质局部AngⅡ蓄积从而启动肾小管间质纤维化的重要机制之一。

This observation has practical implications because these findings can be misinterpreted as intraretinal or subretinal fluid, possibly prompting unnecessary interventions.

这项结果具有实际意义，因为这些研究结果可被误认为视网膜内或视网膜下积液，也可能导致不必要的干预。

In addition, we had obtained evidence of harboring the lysogenic phages in Stroptococcus suis type 2, but the relationship of this phage with the bacterial virulence and adaptation was uncertain.

尤其是猪链球菌2型，不仅对猪致死性强，而且可引起人的感染和死亡1998—1999年夏季曾在我国江苏省部分地区猪群中暴发流行2型猪链球菌病并导致相关从业人员感染。。。。。。

Decrease in serum estradiol level after ovariectomy leads to reduce of lipid quality of the meibomian gland acinar epithelium, which is one of causes for the dysfunction of meibomian gland.

卵巢切除后血清雌二醇水平降低，可造成睑板腺腺泡上皮细胞脂质减少，是导致睑板腺机能障碍的原因之一。关键词：卵巢切除术；大鼠；睑板腺机能障碍；组织构建

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Brane, such as synoviocytes, macrophages, osteoclasts and TNF-αvv acts on different kinds of cell in synovial memchondrocytes, which can produce metalloproteinase,collagenase, stromelysin and so on, further induce pannus formation, joint inflammation, bone erosion and cartilage degradation.

TNF-α可作用于RA关节组织中的滑膜细胞、巨噬细胞、软骨细胞和破骨细胞，使这些细胞活化，产生金属蛋白酶、胶原酶、基膜溶解酶等，导致局部炎症反应和血管翳形成，进一步引起软骨破坏和骨侵蚀。

Some insects neither phytophagous nor natural enemies can also play a role to certain degree. Diversity at the increase phase is the biggest, and if it is big enough,outbreaks of pine caterpillars can be suppressed,otherwise the outbreaks can occur.

松毛虫不同发生阶段中，上升阶段多样性最大，如此时多样性足够大，可有效地抑制松毛虫的暴发，否则松毛虫将在竞争中占优势地位，数量猛增，导致大发生。

Stroke can damage brain cells, and that can cause a depression that is not psychiatrically based, but physiologically based," he says."

中风可损害脑细胞，并可能导致不是精神病学而是生理学为基础的抑郁症&，他说。&

But whatever measures will be taken, the first step is to observe the virability of virulence and the structure of the populations of Puccinia striiformis West.

关于体细胞重组前人有了一些初步研究，但到底是否可通过体细胞重组导致毒性变异没有确切的理论依据。

Sex of vitamin D lack is rachitic the common disease that is infant period, frequently-occurring disease, vitamin D lack is divided outside can causing system of skeletal, nerve, muscle and haemal biochemistry change, still can immunize function drops, cause all sorts of infection, relapse especially respiratory tract is affected .

概要： 维生素D缺乏性佝偻病是婴幼儿时期的常见病、多发病，维生素D缺乏除可引起骨骼、神经、肌肉系统及血液生化改变外，还能使免疫功能下降，导致各种感染，尤其是反复呼吸道感染。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。