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Background Slowly activating delayed rectifier potassium currentI_(Ks is important in therepolarization of human cardiomyocyte action potential,especially in forming andmaintaining plateau of action potential. I_ channel is combined byαandβsubunits,which are coded by KCNQ1 and KCNE1 respectively. Mutations ofhKCNQ1/hKCNE1 genes,chronic myocardial hypertrophy and chronic heartfailure will lead to dysfunction of I_ and ingenital or acquired LQTS which areimportant factor in hazardous ventricular arrhythmia such as Torsade depoints.

实验背景缓慢激活延迟整流钾电流I_(Ks是参与人心肌细胞动作电位复极,特别是平台期形成与维持的重要外向离子流。I_通道由KCNQ1基因编码的α亚单位及KCNE1基因编码的β亚单位组成。hKCNQ1/hKCNE1基因突变或慢性心肌肥厚、慢性心力衰竭等病理过程均可导致I_功能异常,引起遗传性或获得性长QT综合征,LQTS易引起尖端扭转型室性心动过速等心律失常,从而危及病人生命。

In addition, different elements were tested as internal standards for matrix effect correction under the CCT mode, and it was found that Re was best.

在优化的条件下,基体导致的氧化物和氢氧化物质谱干扰可降低25~70倍。研究了CCT模式下不同内标元素用于基体效应的校正。

The results showed that hyperhomocysteinemia was induced by restraint stress. The highest CBS enzyme activity was seen in rat livers. A decrease in hepatic activities of CBS was found in restraint stress rats. The 29.4%±2.5% reduction in the activity of CBS was accompanied by a 44.1%± 3.4% decrease in its mRNA level. CBS enzyme activity was slightly elevated in the kidney of stressed rats while it was almost undeterminable in the cardiovascular system.

结果可见,束缚应激可导致大鼠高同型半胱氨酸血症的发生; CBS在肝脏具有最强的代谢活性,肾脏其次,而心脏和血液中活性极低;应激大鼠肝脏CBS活性和mRNA水平均显著降低( P 。05),应激3周时分别为对照组的70.6%±5.9%和55.9%±4.3%。

In the last part, we have studied the self-assembly behavior of PS-b-PMMA/PS blend solution in a non-selective solvent - toluene by using LLS,viscometry and NRET fluorescence spectroscopy.

这里,溶液中PS和PMMA嵌段通过络合作用形成了核,它为可溶解的PS嵌段所稳定,后者构成胶束的壳,即所谓络合导致的胶束化。

Over a long period of time, water from poisoned welsh may lead to deadly cancers.

经过很长的时间,从有毒的井里打出的水可导致致命的癌症。

Beginning from summarize different financial systems' information characters; we discussed the interactive relationship between the bank innovation process and the information external acquirable features in three financial systems.

而两条分析线索是:第一,不同金融系统中企业信息外部可得性的差异;第二,由外部约束导致的不同金融系统中,企业外部融资资源的差异。

Transgenic expression of IL-1ra and degree of audiogenic seizure of P77PMC rats were observed after infection with pHSV-IL-1ra virus (〓 virus particles) by i. c. v injection and hippocampus injection. Results show: 1. Overexpression of IL-1ra by pHSV-IL-1ra significantly inhibited seizure attacks of P77PMC rat.

实验结果提示IL-1β可导致神经细胞NMDAR mRNA表达及受体活性增加,从而使其兴奋性增高;脑中内源性IL-1系统的异常很可能是形成P77PMC遗传癫痫易感大鼠惊厥易感性的重要因素之一;我们首次构建并鉴定了pHSV-IL-lra重组质粒,并成功地进行了脑内基因转移,使P77PMC大鼠的惊厥程度明显降低。

Amino acid chelated magnesium as feed additive can treat or remit stress and intension of some animal to result in cacoethes and aggressive behavior, reduce animal's activity caused by excitation, and thus save feed and raise feed converting rate.

本发明的有益效果是将氨基酸螯合镁作为饲料添加剂,能够治疗或缓解动物一些应激和紧张造成的恶癖和攻击性行为;还可用于减少动物因兴奋导致的活动量增加,从而达到节省饲料能量,以提高饲料的转化率。

Internal hernias are clinically apparent only when incar cerated internal hernias result from small bowel obstruction; therefore, a delay in diagnosis may lead to strangulation and an increased risk of serious complications.

腹内疝仅在小肠梗阻发展到腹内疝嵌钝才表现出明显的临床症状,因此,延误诊断可导致肠绞窄并增加其他严重并发症的危险性。你知道它的英文吗?

In case of a spinal correction-stabilization of the cervicothoracic junction due to progressive deformity or instability caused by for instance osteoporosis, trauma, neurofibromatosis, or infection, the same ventral approaches can be used.

对颈胸结合部脊柱矫形固定的病例,如进行性加重的畸形或由于骨质疏松症、创伤、神经纤维瘤病及感染导致的不稳定,可使用相同的腹侧入路。

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