变粗糙

They find rough spots in the language and smooth them out.

他们发现这种语言中的粗糙之处，并使它变得顺畅。

Basal petioles 10–20 cm; blade broad-triangular, 10–15 cm, ternate-2-pinnate; pinnae petiolulate; petiolules 3–6 cm; ultimate segments subovate, 3–11 × 2–6 cm, undivided or 2–3-lobed, both surfaces slightly roughened, sharply serrate or doubly serrate.

基部的叶柄10-20厘米；叶片宽三角形，10-15厘米，三出2回羽状；羽片具小叶柄；小叶柄3-6厘米；末回裂片近卵形， 3-11 * 2-6 厘米，不裂或2-3浅裂，两面稍变得粗糙，锐的有锯齿或重锯齿。

The palm of your hands will thicken.

你的手掌会变得粗糙。

An unoiled instrument reacts on the breath moisture- the wood expands, becomes rough and the sound deteriorates.

没有上油的乐器会对吹笛时呼出的潮气起反应——木头扩张，变得粗糙，音质变坏。

By using the variational method the roughness length is calculated and is equal to 0.03 m.

用变分方法计算的地面粗糙度为0.03m。

Ultraviolet and dirty air pollution will make skin rough and lightless, even spot. This product adopted advanced and sound technology, to compound aweto, animal oil (lanolin imported form Australia) and collagen protein. Provide effects of anti-wrinkle, moisturizing, nutrients and isolation. Whiten your skin in short time and make your skin moisture and smooth for long period.

紫外线、脏空气的污染和侵害，使脸部肌肤变得粗糙、暗淡无光、严重得引起色斑的产生和加重，本品配方采用了先进的、合理的领先技术，精心设计配方，把植物、动物油，和胶原蛋白同时添加于本产品中，使肌肤达到抗皱、滋养、隔离的效果，使用后，短效间使肌肤美白，长效间使肌肤滋润光泽。

His lips were all chapped and rough.

他的嘴唇全都皲裂了，变得很粗糙。

When vitamin A effect having stout , lubricating skin , is short of, skin becomes dry , rough; Vitamin B has the fleck effect to extend a wrinkle , removes; Vitamin C may prevent the skin blood vessel from ageing , strengthen blood vessel elasticity , increase white skin, effect cutting down skin chromatosis; Decrease acne the and pigment come into being Wei Sheng Su E , have and resisting the effect old and feeble.

维生素A有强健、润滑皮肤的作用，缺乏时，皮肤变得干燥、粗糙；维生素B有舒展皱纹、消除斑点作用；维生素C可防止皮肤血管老化，增强血管弹性，增白皮肤，减少皮肤色素沉着的作用；维生素E可减少痤疮和色素生成，并有抗衰老作用。

Results show that the alumina formed on the corroded NiCoCrAlY coating is roughness, cracked and incontinuous and many pits was formed on the surface of the coating after the salt-spray test.

试验结果表明：经过盐雾腐蚀的涂层表面的均匀性和完整性均被破坏，涂层表面产生了大量的腐蚀坑；高温循环氧化以后，表面形成的Al2 O3 氧化膜变得粗糙、破碎且不连续，而且氧化膜容易剥落，降低了涂层的高温抗氧化能力，缩短了涂层的使用寿命

Light microscope and transmission electron microscopy showed that SMMC-7721 cells induced by SAHA had undergone the restorational alteration in morphology and ultrastructure, which were different from those of nontreated cells but were similar to those of normal cells, and the changes were as follows: the cells turned to be flat and spread; the nucleo-cytoplasmic ratio lessened and nuclear shape became rather regular; the number of nucleolus reduced and its volume lessened; euchromatin increased while heterochromatin decreased in nucleus; in the cytoplasm, mitochondria grew in number with relatively consistent structure and well-developed mitochondria cristae; Golgi complex turned to be well-developed and typical; rough endoplasmic reticulum increased. Immunocytochemistry assay showed that the expression of AFP and PCNA were declined significantly. FCM analysis showed SAHA could arrest SMMC-7721 cells in G0/G1 phase, with an accumulation of the cells in G0/G1 phase while a decrease of cells in S phase. Semi-quantitative RT-PCR detection revealed that the expression of p21WAFl mRNA was upregulated remarkably in the cells treated with SAHA.

结果：倒置显微镜和透射电镜观察显示，经SAHA处理的细胞增殖速度显著减慢，细胞体积增大，细胞核较小，形状较为规则，核仁数量减少、体积变小，核内常染色质增多而异染色质减少，核质比例减小，细胞质内线粒体数量增多、线粒体嵴发达，高尔基体较为典型，粗糙型内质网增多，呈现出与正常上皮细胞相似的形态变化；MTT比色法测定结果显示不同浓度(2.5、5.0、7.5、10.0uM)SAHA对SMMC-7721细胞的增殖均有抑制作用，并有明显的剂量依赖和时间依赖关系；免疫细胞化学检测显示SAHA能显著降低PCNA和AFP在SMMC-7721细胞中的表达；流式细胞仪检测结果显示，SMMC-7721细胞经SAHA处理后，G0/G1期细胞明显增加，S期细胞则明显减少，细胞被阻滞于G0/G1期；RT-PCR检测结果表明，SAHA作用12h后SMMC-7721细胞中p21WAF1 mRNA的表达即有增加，24h后更为明显。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。