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According to senior author Howard Rockman, MD, also from Duke, the physical linkage of the receptors could allow physicians more flexibility in heart failure treatment. Because angiotensin blockers are better tolerated, they could be given alone to patients too sick to take beta-blockers. A single, potent drug targeting both receptors could reduce the need for multiple medications with increased potential for drug interactions and adverse events.

Howard Rockman指出,这些药物在治疗心脏衰竭的成效可以归因于它们并非以单一受体作为目标,这些研究结果也可以为心脏衰竭的患者订作药物疗法,不同受体的补体在不同患者及不同的疾病严重性之间有所差异,所以辨识患者单一性受体组成的血液试验,将可以让内科医生指定最适当药物治疗。

Methods: Spontaneous activities of the dorsal hippocampal field CA1 neurons were extracellularly recorded by single-barreled electrode in intact awake rat, which was paralyzed with pancuronium and whose respiration controlled via a nonrebreathing system.

NMDA受体是中枢神经系统最主要的兴奋性递质门控离子通道受体,但对于NMDA受体是否是静脉麻醉药丙泊酚全麻作用的分子靶位,目前尚存在较大的争议和分歧。

The whole cell-patch clamp recording technique was used to record I in specific pipette solution and superfusion according to specific holding potential and command potential program.

采用经典的酶分离心肌细胞方法,应用全细胞膜片钳技术记录I,观察MI后I、的变化,予以β2受体激动剂salbutamol、β受体激动剂异丙肾上腺素及不同选择性β受体阻滞剂后I的变化。

The relations between the gene mutation of the retinoic acid acceptor, various retinoic acid acceptors and their ligands and teratogenesis of retinoic acid are summarized in this article.

对视黄类受体基因突变和不同视黄类受体及其配体与致畸作用的关系,以及此类受体对其它基因表达的调节作简要综述。

This thesis conclude 4 parts: 1 、 The change and effecting factors of plasma adiponectin level in old subjects with abnormal glucose tolerance; 2、 The distribution of adiponectin receptors in Wistar rat; 3、 The effect of fat-fed and pioglitazone on mRNA expression of adiponectin with its receptors...

本研究共包括以下四部分内容:1、老年糖耐量异常人群中脂联素的改变及其影响因素;2、脂联素受体mRNA在Wistar大鼠体内的分布;3、高脂饲养以及吡格列酮对大鼠脂肪组织脂联素及其受体表达的影响;4、吡格列酮对不同浓度脂肪酸培养的HepG2细胞脂联素受体mRNA表达的影响。

Polar distribution of Con A receptors was observed on the plasma membrane of unfertilized egg cells and central cells.

在蚕豆和莺尾的生殖细胞表面均有这三种凝集素的受体。在朱顶红生殖细胞表面有前两种凝集素的受体,分布比较均一,但是没有大豆凝集素的受体

Cardiac AT〓 receptor and β〓-adrenergic receptor are GPCR.Their function in signal transduction pathway has not been studied.

心脏AT〓受体和β〓受体均属G蛋白偶联受体,它们在该信号传导通路中的作用尚未深入研究。

This review will summarize several aspects concerning the distribution of agmatine and NMDA receptors in the central nervous system, the binding sites of agmatine on NMDA receptors as well as the pharmacological functions closely associated with NMDA receptors.

本文就胍丁胺与NMDA受体在中枢神经系统的分布、胍丁胺在NMDA受体上的作用位点以及胍丁胺通过NMDA受体介导的药理作用等几个方面进行了综述。

Present study, therefore, is to directly demonstrate whether I1-imidazoline receptor participates in the modulation to morphine dependence by agmatine, and to discuss its molecular mechanism in signal transduction aspect.

本文 旨在首次提供直接证据以阐明I1-眯唑啉受体是否介导了胍丁胺对吗啡依赖的调节,并探讨I1-咪唑啉受体受体后水平抑制吗啡依赖的可能分子机制。

Being the most abundant colostral Ig component in livestock animals, IgG must be transported across epithelial barriers through transcytosis when it is secreted from mammary gland to milk and when it is absorbed by the newborn animals,through a specific IgG transport receptor,namely the neonatal Fc receptor.

IgG是家畜初乳中含量最丰富的免疫球蛋白成分,IgG由乳腺向乳汁中的分泌以及新生动物对乳中母源IgG的摄取均需要穿越上皮细胞屏障,即进行细胞转运作用,这一过程是由受体介导的,而特异性转运IgG的唯一受体是新生儿Fc受体(neonatal Fc receptor,FcRn)。

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