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KIR bind corresponding HLA-Ⅰmay hame four results followed:1、When inhibitory KIR bind HLA-Ⅰand there has no activatory KIR bind it,cell isn\'t dissolve because inhibitory signal access was done;2、When activatory KIR bind corresponding HLA-Ⅰand there has no inhibitory KIR bind it,form activate signal,lead cell dissolve.3、If activatory or inhibitory receptor both bind HLA-Ⅰ,both signal access is make done,when activatory signal play the main role,NK cell still actived,lead target cell dissolve.4、If activatory or inhibitory receptor both bind HLA-Ⅰ,both signal access is make done,when inhibitory signal play the main role,or both signal access don\'t play,NK cell do not make effect.this is NK cell recognice nomal tissue.

与活化型KIR受体相比,抑制型KIR受体与HLA-Ⅰ类抗原结合的亲和性更强,当抑制型和活化型KIR受体识别和结合同一HLA-Ⅰ类抗原分子时,以抑制作用为主。KIR与相应HLA-Ⅰ结合后可能产生以下4种情况:①当抑制型KIR与HLA-Ⅰ结合而无活化型KIR与HLA-Ⅰ相互作用时,因抑制信号通路启动而不产生细胞溶解;②当活化型KIR与靶细胞表面的相应HLA-Ⅰ结合同时无抑制型KIR与HLA-Ⅰ的相互作用时,形成刺激信号通路,导致靶细胞溶解。

Methods Adult New Zealand white rabbits (n=10) as recipients were divided into 5 groups and one-month age New Zealand white rabbits (n=20) served as donors. The homograft valved conduits harvested from the donors were transplanted into the bilateral aorto-carotid in 10 recipients. The homografts were harvested from one group at 7, 14, 28, 60, 120 days after transplantation to examine blood flow and thrombus of homografts.

成年新西兰兔10只作为受体分5组。1个月龄的新西兰白兔20只作为供体,取其主动脉带瓣血管,移植于受体的两侧颈动脉,术后7、14、28、60、120 d分别取出每组受体所移植的同种瓣并观察血流通常情况及有无血栓形成。

The results indicated that the three extracts from the M.maudiae leaves had inhibited the seed germination rate, the root length, seedling height and fresh weight of three plants to some extent, and the protein content and the activity of perxidase and hyperoxide mutase in the seedlings were also decreased. However, the content of malondiadehyde was increased.

结果表明,深山含笑叶片自然挥发物、水浸提液和挥发油降低3种受体的发芽率,对受体的根长、苗高和鲜重有不同程度的抑制作用;并均使3种受体幼苗蛋白质含量、SOD、POD活性降低,MDA含量增加。

In the present study, weclarify the capsaicin concentration dependency for developmentand maintenance of secondary mechanical allodynia and the roleof spinal opioid receptor like1 (ORL1) receptor and N -methyl-d-aspartatereceptor in the development and maintenance of secondary mechanicalallodynia induced by an intradermal capsaicin injection. Capsaicin50 L of 0.03% induced the most intense secondary mechanicalallodynia.

在这个实验中,作者研究皮内注射辣椒素与继发性机械性异常性疼痛的相关性和脊髓阿片受体相关1受体激动剂( ORL1)和 N-甲基-D-天门冬氨酸受体在皮内注射引起的继发性机械性异常性疼痛的发生和维持中的作用。0.03%的辣椒素50uL 导致最强的异常性疼痛。

Mannose receptor is one member of the mannose receptor family and belongs to C-type lectin receptor.

甘露糖受体为甘露糖受体家族的成员,属于C型凝集素受体

Object To investigate the effects of chronic nicotine treatment on the functions and gene expressions of monoamine receptor.

目的 研究烟碱对多巴胺受体、肾上腺素受体、5 羟色胺受体功能及基因表达的影响。

Thus, not only will it be important to assess the role of gonadal steroid regulation of AT2R action and the impact of AT2R mosaicism in BP control, we also need to determine whether the higher AT2R expression in the female is a result of escape from X inactivation.

因而我们不仅要评估性腺激素对于血管紧张素II受体影响以及血管紧张素II受体在血压调控中的作用,还要明确在女性中血管紧张素II受体的高表达是否与第二条X染色体的失活回避有关。

By retrovirus vector the foreign mdr1 gene could be efficiently transferred into bone marrow mononuclear cells of mouse in vitro, and it was confirmed that mdr1 gene was expressing stably and effectively in cells; in short terms there is no significant influence on the bone marrow MNC by transfection of mdr1 gene,but in the long run(in our study we had surveyed 2 months),there is a decline in the expression of apoptosis factor Bax in the MNC which transfected by mdr1 gene,in favour of the recovery of the receptor mouse;on the other hand it also poses a blance problem between multiplication and apoptosis in the process of receptor hematopoiesis after transplanting HSC which was transfected with mdr1 gene.

通过逆转录病毒载体可在体外将外源性mdr1基因转入小鼠骨髓单个核细胞中,转染的mdr1基因能整合到骨髓单个核细胞基因组中并有功能性表达;mdr1基因转入小鼠骨髓单个核细胞在移植后短期内对受体造血细胞没有显著影响,但从长期看来(本研究观察2个月)转染了mdr1基因的造血干细胞的凋亡因子Bax表达降低,更有利于受体鼠造血的恢复;另一个方面它也同时提出一个问题,即mdr1基因转染造血干细胞在回输受体后造血过程的增殖凋亡平衡。

Results:①In normal extracellular solution, the non-selective cholinergic agonist acetylcholine and the muscarinic agonist muscarine both caused the increace of [Ca2+]i in separately 21 out of 25 and 14 out of 18 VHCs I, while only 3 out of 20 and 2 out of 16 VHCs I had a weak increase of [Ca2+]i if investigated in calcium free extracellular solution; nicotine could increase the [Ca2+]i in 7 out of 32 VHCsⅠonly at enough high concentration(up to 10 mmol/L) in normal extracellular solution, this [Ca~(2+)]_i increase by nicotine at high concentration could not be investigated if at calcium free solution.

结果①非选择性胆碱能受体激动剂乙酰胆碱、M型胆碱能受体激动剂毒蕈碱在正常细胞外液中均可引起大部分(21/25, 14/18)单离VHCⅠ[Ca~(2+)]_i的升高,但无钙外液中ACh、muscarine仅使少部分(3/20,2/16)VHCⅠ[Ca~(2+)]_i升高且作用减弱;正常外液中,N型受体激动剂尼古丁仅在高浓度(≥10 mmol/L)时引起部分(7/32) VHCⅠ[Ca~(2+)]_i升高,在低浓度时对胞内钙离子浓度影响不明显,无钙外液中,10 mmol/L nicotine对胞内钙离子浓度影响不明显。

Each olfactory receptor cell possesses only one type of odorant receptor, and each receptor can detect a limited number of odorant substances.

每个嗅觉受体细胞只拥有一种类型的气味受体,每受体可以探测到数量有限的气味物质。

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If you have any questions, you can contact me anytime.

如果有任何问题,你可以随时联系我。

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很漂亮,不过停机坪更迷人。那人俏皮地答道。