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Objective To investigate the expression and pathobiological implications of angiotensin Ⅱ type 1 receptor in development of myocardial fibrosis of rats.

目的 探讨血管紧张素Ⅱl型受体在心肌纤维化中的表达及其意义。

Abstract] AIM: To investigate the effects of angiotensin II receptor antagonist on remodeling of renal arterioles in hypertension.

摘 要]目的:研究血管紧张素II受体拮抗剂对高血压肾小动脉重建的影响。

We have determined the crystal structure of the human A2A adenosine receptor, in complex with a high-affinity subtype-selective antagonist, ZM241385, to 2.6 angstrom resolution.

我们已经在复杂的具有高亲和性亚型选择性拮抗剂ZM241385中,已经确定了以2.6埃分辨率的人类A2A腺苷受体晶体结构。

Heat intolerance with hypohidrosis or anhidrosis has been recently reported in children undergoing epilepsy treatment with TPM.

可以增加γ-氨基丁酸激活GABAA受体的频率,加强氯离子内流,增强抑制性中枢神经递质的作用[4,5];3。

Objective To evaluate the effect of a gastrin receptor antagonist in the treatment of gastric cancer.

目的 探讨应用胃泌素受体拮抗剂治疗胃癌的可行性。

Objective To observe the protective effect of α-receptor antagonist against aging process in rats.

目的 观察α-受体阻滞剂对大鼠球囊功能老化的保护作用。

Specifically, it is an H1 receptor antagonist.

具体来说,它是一种H1受体拮抗剂。

Adrenoceptor antagonization did not change the tension of femoral artery, but abolished the ISO induced vasorelaxation of coronary artery.

1受体阻断不影响ISO产生的股动脉血管舒张,但消除了冠状动脉的血管舒张。

METHODS The organ-bath was used to observe the tension changes in rings of coronary and femoral arteries to different concentrations of isoprenaline ISO after endothelium removal, nitric-oxide synthase NOS inhibition by L-NMMA and β1 andor β2 adrenoceptor antagonization.

利用器官组织浴血管环法观察冠状动脉和股动脉在给予不同浓度的异丙肾上腺素ISO后血管张力的变化,以及去除血管内皮,一氧化氮合成酶NOS抑制,β1和或β2受体阻断后对其的影响。

RESULTS Endothelium removal, NOS inhibition,β2 adrenoceptor antagonization did not change the vasorelaxation induced by ISO in coronary artery, however, abolished the vasorelaxation in femoral artery.

结果 无论冠状动脉或股动脉ISO均产生浓度依赖的血管舒张。去除内皮, NOS抑制,β2受体阻断不影响ISO产生的冠状动脉血管舒张,而完全消除了股动脉的血管舒张。

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