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Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) recommends treating most patients with stage 2 hypertension (160/100 mm Hg or higher) with a two-drug combination of a thiazide diuretic plus an ACE inhibitor, angiotensin receptor blocker, beta blocker, or calcium channel blocker.

美国国家联合委员会关于高血压预防、诊断、评估与治疗第七次报告(JNC 7)建议,大多数2期高血压(≥160/100 mm Hg)患者应接受一种噻嗪类利尿剂加一种血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂、β受体阻滞剂或钙通道阻滞剂的两药联合方案治疗。

In male, three kinds of sex steroid receptors were distributed in the spermatogonia, spermatocytes and spermatids, and the positive reaction was localized in the cytoplasm and nucleus of these spermatogenic cells.

在雄性,3种类固醇激素受体分布在不同发育时期的精原细胞、精母细胞和精子细胞中,受体阳性物定位在胞质和核。

In vertebrate organisms,thesignaling pathway is initiated by the binding of ligandsto the membranousreceptor patchedwhich in turn alleviates the suppression on smoothened,subsequently Smo triggers a series of intracellular events with resultant activation of thezinc-finger transcription effectors,glioma-associated oncogenes(Glil,Gli2,Gli3)transcription factor,which induces the expression of numerous target genes,such as Ptch-1,Hip,Gli1 and Wnt,that regulate proliferation,differentiation.

Hedgehog信号通路是高度保守的调控胚胎组织分化发育的通路,在脊柱动物体内,Hh蛋白与跨膜受体Ptch结合后,解除了Ptch对Smo的抑制,随后Smo从共受体上解离下来进入胞浆,将信号下传并激活锌指转录因子Gli,后者启动Ptch-1、Hip、Gli1、Wnt等目的基因的表达,进而调控细胞的增殖、分化。

The transfected COS-7 cells showed approximately 90% rosetting. A stable transfected COS-7 cell line expressing boFcγ2R was established.

最后获得稳定表达boFcγ2R受体分子的COS-7转染细胞系,为受体的功能研究提供了良好的技术平台。

In mammals the Notch gene family comprise four related genes, Notch1-4, as the Notch ligands that encode transmembrane proteins. Ligand-receptor interaction mediated Notch activation ultimately leads to the conversion of effectors-CSL CBF1, Su(H, Lag-1 proteins, from repressors to transcriptional activators, and subsequent up-regulation of downstream targets.

在哺乳动物中,Notch基因家族包含了4个相关的基因,分别为Notch-1至-4,和Notch受质蛋白一样能被转译成膜蛋白;受质-受体间相互作用所引起Notch受体蛋白的活化会促使作用蛋白-CSL CBF1, Su(H, Lag-1 蛋白扮演抑制分子或者是转录活化分子上的角色改变,并且进一步地正向调节下游的标的基因。

The effects of different muscle relaxants with dissimilar structure were various to the adult-and the embryonic-nicotinic acetylcholine receptors.

不同化学结构肌松药对成人型或胎儿型乙酰胆碱受体的抑制程度不同,而成人型或胎儿型乙酰胆碱受体对种肌松药的亲和力也有差异。

the effects of different muscle relaxants with dissimilar structure were various to the adult-and the embryonic-nicotinic acetylcholine receptors.

不同化学结构肌松药对成人型或胎儿型乙酰胆碱受体的抑制程度不同,而成人型或胎儿型乙酰胆碱受体对一种肌松药的亲和力也有差异。

Methods: 458 postmenopausal endometrial polyps were all treated by transcervical recection of polyp,and diagnosed by pathology.The presence of ER,PR, Bcl-2 and Ki-67 were detected by immunohistochemical staining.Following up these cases, 160 cases recured in three months to three years after treatment.These recurrence were treated by large dose mifepristone.After three months, 55 cases remainder EP were detected by hysteroscopy and treated by TCRP,then detected the presence of above receptors in the same way.

绝经后子宫内膜息肉患者458例,均接受宫腔镜下子宫内膜息肉切除术,术后病理诊断均为子宫内膜息肉,并采用免疫组化法检测子宫内膜息肉中雌、孕激素受体及Ki-67、Bcl-2的表达;随访以上患者,术后3个月~3年复发160例,均予大剂量米非司酮口服治疗,3个月后行宫腔镜检查,有残余息肉者55例,再行TCRP,并采用免疫组化法检测子宫内膜息肉中雌、孕激素受体及Ki-67、Bcl-2的表达。

Objective To investigate the expression of Toil-like rectors of 2,4(TLR2,4) on HepG2 cells after tranfection with hepatitis B virus genome, also including secretion of HBV antigen and proliferation of cells.

目的 探讨乙肝病毒全基因组瞬时转染HepG2细胞后,对HBV抗原分泌,病原识别受体Toll样受体2、4(TLR2、4)的表达及细胞增殖的影响。

The paper involved two parts: Part 1: A two-chambered microbial fuel cell was constructed with high-concentration sodium acetate as fuel in the anode. The influence of different electron acceptors in the cathode, external resistance value, pH value and concentration of sodium acetate on electricity generation in MFC was investigated. The result showed that the maximum power density of 294.72 mW/m2 and the coulombic efficiency of 25.87% was achieved at sodium acetate concentration of 6.46 g/L, pH 7.0, external resistance 500Ωin the anode and when using potassium permanganate as electron acceptor in the cathode.

全文分为两个部分:第一部分:以乙酸钠为阳极原料构建双室微生物燃料电池,研究不同阴极受体、外接电阻、乙酸钠浓度和pH等因素对电池产电性能的影响,研究结果表明:在500mL的阴阳极反应体系中,选用乙酸钠作为阳极底物,质量浓度为6.46 g/L, pH 7.0,接入500Ω外电阻,阴极电子受体选择高锰酸钾的情况下,微生物燃料电池产电性能最好,最大电功率密度达到294.72 mW/m2,库伦效率能达到25.87%。

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