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The activation of primary nociceptor cells by FA is likely to be mediated, at least in part, through TRPV1 and/or TRPA1 receptors.

本实验进一步证明甲醛激活初级伤害性感受器细胞可能是通过TRPV1受体和/或TRPA1受体参与介导的。

The combination was superior to chemotherapy alone in patients with inflammatory breast cancer and in those with noninflammatory breast cancer, in those who were hormone-receptor positive and those who were hormone-receptor negative, and in those who had or did not have a complete pathologic response.

这样的状况比单独接受化学治疗的发炎与非发炎性乳癌病患好,其他还包括荷尔蒙受体阳性与那些荷尔蒙受体阴性、以及有或是无完全病理反应的病患。

Vagina sponge bolt and CLO was used in oestrous synchronization of donors and acceptances , the rates of estrus was100.0% and 83.0%. 6mg FSH and CLO was used in superovulation of Hexi Fine wool goat,115 embryos were acquire totally and average14.4 embryos,100 useful embryos, average 12.5 embryos.The surgical operation used in embryos transplant, the rate of Gestation was 82.4%, 47 lambs was birth,and the birthrate of lamb was 167.9%.

采用阴道海绵栓结合氯前列稀醇法对供、受体进行同期发情处理,处理结果的发情率分别为100.0%和83.0%;采用 FSH剂量6m g/只结合氯前列稀醇对河西绒山羊超数排卵,共回收胚胎115枚,头均14.4枚,可用胚胎100枚,头均12.5枚;采用手术法对杂种河西绒山羊受体移植后,妊娠率82.4%,产羔47只,产羔率为167.9%。

Mutant mice than in wild-type controls, and tetrodotoxin or bicuculline application abolished the difference between the genotypes. Studies on human oligodendroglioma cells revealed that GABA played a protective role on Ca〓 overload induced by OGD or glutamate and phaclofen, GABA〓 receptor antagonist, could significantly block the protection.

结果表明:①电凝大脑中动脉后Ca〓2.3-/-鼠脑梗死率和缺血后运动障碍明显重于Ca〓2.3+/+鼠;②Ca〓2.3-/-鼠海马脑片CA1区缺氧后钙超载明显高于Ca〓2.3+/+鼠;③Na〓通道阻滞剂TTX和GABA〓受体阻断剂bicuculline可显著缩小遗传表型之间的差异;④GABA对缺氧无糖及谷氨酸所致的人胶质细胞瘤细胞Ca〓超载有明显的保护作用,此作用可被GABA〓受体阻断剂phaclofen拮抗。

Therefore, RANKL, RANK, and OPG provide a ligand/receptor/soluble receptor system for the molecular basis of osteoclastic regulation by osteoblasts.

这样,RANKL,RANK以及OPG构成了一种配体/受体/可溶性受体调控系统,成为成骨细胞调控破骨细胞的分子基础。

These results show that overexpress the Tra2β1 protein may influence the propotion of the flip/flop of the AMPA receptors, and change the kinetic and ion selective of the receptors. So it can drive the development of the neural synapses.

此实验表明:过表达Tra2β1蛋白可能影响了神经细胞谷氨酸AMPA型受体flip/flop型剪接的比例,并且改变了AMPA受体的动力学和离子选择特性,从而加速了神经突触形成的发育进程。

Cardiac hypertrophy and extracellular matrix remodeling happened as a result of chronic overrange of pressure in heart and hypervolaemia which lead to damage of relaxation and compliance of heart.Drugs including renin-angiotensin converting enzyme inhibitor,angiotensin receptor blocker,aderergic receptor blocker,aldrosteron antagonism,tatins endothelin receptor blocker pancreatic kiniogenase and calcalium channel blocker,can delay or reverse the remodeling by several mechanisms.

主要表现为心脏在慢性超负荷的压力、容量作用下发生的病理改变致使左室肥厚组织胶原结构发生改变,导致心肌顺应性降低,舒张功能受到损害;作用于肾素-血管紧张素系统的药物及肾上腺素受体阻滞剂、醛固酮拮抗剂、他汀类药物、内皮素受体拮抗剂、胰激肽原酶、钙通道阻滞剂等药物通过不同途径和机制延缓和逆转左心室重构。

Methods: To establish a rat model of pancreaticoduodenal transplantation with venacava endocrine drainage and enteric eccrine drainage. The recipient rats were introperitoneally injected with 15 mg/kg of proline dithiocarbamate in experiment group and with equal amount of normal saline in control group 30 minutes before transplantation.

建立大鼠腔静脉内分泌引流、肠道外分泌引流的动物模型,脯氨酸二硫代氨基甲酸酯组供体胰腺保存在ProDTC的UW液中,受体鼠于移植前30min腹腔注射ProDTC(15mg/kg);对照组供体胰腺仅保存在UW液中,受体鼠腹腔注射等量生理盐水,分别于再灌注后第0、1、3、6、12、24h等时点,处死大鼠,取血后切取移植胰腺。

Methods Six weeks old male Fischer 344 rats (F344) were used as donors, and six weeks old male F344alb as recipients. All F344alb were divided into 4 groups: group Ⅰ(n=10) was untreated; group Ⅱ(n=10) was treated with CCl4 but no γ-irradiation and transplantation; group Ⅲ(n=10) was transplanted with 1×10^7 BMCs after γ-irradiation, but without CCl4 treatment; group Ⅳ(n=10) was transplanted with 1×10^7 BMCs after γ-irradiation, with CCl4 treatment. The BMCs prepared from the donors were infused via the penial veins of recipients immediately after whole body γ-irradiation (7.5Gy) and CCl4 treatment: 4 weeks after BMCs transplantation, CCl4 were injected into peritoneal cavity twice a week for 4 weeks.

雄性F344大鼠为供体,而雄性F344alb为受体,分为4组:组Ⅰ(n=10)为正常对照组,不接受肝损处理,无全身射线照射和阴茎静脉骨髓细胞移植;组Ⅱ(n=10)为肝损无移植组,只接受肝损处理,无全身射线照射和阴茎静脉骨髓细胞移植;组Ⅲ(n=10)为正常移植组,全身射线照射后阴茎静脉移植骨髓细胞1×10^7;组Ⅳ(n=10)为肝损移植组,接受CCl4注射肝损,全身射线照射后阴茎静脉骨髓细胞移植1×10^7BMCs,其中,γ-照射剂量为7.5Gy,F344大鼠的BMCs经受体的阴茎静脉注入。

The effects of Caoguozhimu Decoction, a TCM antiepileptic, on NMDA receptor binding capacity and the expression of NMDAR1 mRNA in pentylene tetrazole-kindled rat model were observerd by the ligand-receptor method and i n situ hybridization, with MK-801 as a contrast.

观察抗癫痫中药草果知母汤在阻断戊四唑点燃模型形成过程中,对兴奋性氨基酸类神经递质Glu的受体NMDA结合力及其NMDAR1 mRNA的影响。以NMDA的竞争性拮抗剂MK- 801为对照,用配基受体法、原位杂交法检测相应指标的变化。

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