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Pike protein consists of S1 and S2 subunit. S1 is head and S2 is rod-shape part, intermolecular effort can bind each other. S1 can bind with host cell epimembranal acceptor. S2 can fix integral Spike protein on the cellular membrane and mediate cell-fusion with virus and host cell. There are significant antigen determinant of virus in Spike protein, genic heterogenesis can effect viral pathogenicity. SARS-CoV Spike protein, which has 23 pieces larvaceous glycosylation sit, consists of 1256 amino acid. Its N-terminals and C-terminals is corresponding conservative.

蛋白是I型膜糖蛋白,介导病毒与宿主细胞膜上的受体结合并与宿主细胞膜相融合。S蛋白由S1和S2两个亚基组成。S1形成球状部分,S2形成棒状部分,两者之间通过分子间的作用力相互结合。S1能与宿主细胞上的受体结合,S2可把整个S蛋白固定在细胞膜上,并介导病毒包膜与宿主细胞膜融合。S蛋白上有重要的病毒抗原决定簇,S基因的突变会影响病毒的致病性。

This review focuses on the roles of MC3R and MC4R in regulation of food intake and energy homeostasis.

本文综述了黑素皮质素受体3和受体4基因调控采食量和能量稳态的研究进展。

It regulates the formation of gameter and hormonic function through secreting as a pulse model from the hypothalamus and combining with a specific receptor named GnRH receptor in pituitary anterior to stimulate the secretion of LH and FSH.

在垂体前叶内,GnRH作用于促性腺激素分泌细胞特异性的GnRH受体,通过受体的介导,刺激LH和FSH的分泌,从而调节性腺内配子形成和激素功能。

Then using selective antagonists for mAChR and nAChR, inhibitor of PKC and MAPK, respectively, we probed into the molecular mechanism underlying the regulation of APP processing by HupA.

采用毒蕈碱样乙酰胆碱受体和烟碱样乙酰胆碱受体的特异性拮抗剂,以及PKC和有丝分裂原激活的蛋白激酶(mitogen-activated protein kinase, MAPK)的抑制剂,探讨石杉碱甲调节sAPPα分泌的分子机制。

PH-20 is a traditional sperm membrane antigen,and it is a glycophosphatidylinositolanchored hyaluronidase.

PH-20(posterior head 20)作为传统的精子膜抗原,是由磷脂酰肌醇(glycophosphatidylinositol,GPI)锚定的膜结合型透明质酸酶,最适PH值呈中性,它分布于精子表面浆膜和顶体内膜,是一种透明质酸酶诱导信号转导的受体和识别透明带的受体

Hyperalgesia after thermal stimulation is also mediated by non-NMDA, but not NMDA, receptors.

热刺激后痛觉过敏也由非 NMDA 受体而不是 NMDA 受体介导。

It can stimulate neurotropic receptor to powerfully motivate Transient Receptor Potential Ion Channels which are the vanguard of Cell Sensory Systems to mediate sensory transduction, responding to temperature, touch,pain, sweet, bitter, taste, osmolarity, pheromones, warmth, heat, cold, stimulus and hypertonicity.

它可以刺激神经受体有力地激发瞬间受体电位离子通道,这是先锋的细胞感觉系统来调解感觉传导,反应温度,触摸,疼痛,甜,苦,味道,渗透压,信息素,暖,热,冷,刺激和肌张力亢进。

We have used our anti-MNTF monoclonal antibody and MNTF-anti- idiotypic monoclonal antibody (MNTF-Id-McAb) to study the changes in localization and quantities of MNTF and its receptor in tongue muscles of 30 adult rats after 4 days, 2, 3 and 5 weeks, and 2 and 5 months of post-denervation of the hypoglossal nerve.

用本实验室制备的运动神经元诱向因子单克隆抗体和与其受体能特异结合的MNTF抗独特型单抗(MNTF-Id-McAb),对切断一侧舌下神经的30只大鼠舌内肌,分别在手术后4d,2周、3周和5周以及2个月和5个月,检测其MNTF和MNTF受体定位和含量的变化。

These results suggested that hypotonicity inhibited ATP-actived currents via TRPV4 receptor, which was mediated partly by reducing cAMP concentration directly rather than by PKA and downstream process.

以上结果表明,低渗透压作用于TRPV4受体,可能通过直接抑制cAMP的生成而抑制P2X受体介导的电流,从而发挥对ATP激活电流的抑制作用。

Muscle type AchR is an important medium of neuronal transmission and main immunogen of Myasthenia gravis,as well as some diseases were induced by the mutation of neuronal\|typed AchR.

肌肉型乙酰胆碱受体是肌肉神经传导中的重要媒介物质以及自身免疫疾病重症肌无力的主要免疫原,神经型乙酰胆碱受体的突变也可导致某些疾病的发生。

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And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47:5 法老对约瑟说,你父亲和你弟兄们到你这里来了。

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