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Study on molecular characters of atagonist indicated that neonicotinoids insecticides and the active pharmaceutical group displayed electro-negative and electro-positive, and study on the interaction between atagonist and nAChR at the complex of subunit of insect and subunit of mammalian indicated that the effect of basic aminoacid in D ring of binding location of ACh is very obvious, and the YXCC in C ring of binding location also attracted the attention too.

激动剂的分子特点研究表明,新烟碱类杀虫剂和ACh药效基团在静电性上分别显示负电性和正电性。用昆虫亚基和脊椎动物亚基组成的杂合受体同激动剂相互作用的研究,主要集中在受体亚基上不同氨基酸残基与不同激动剂结合电生理效应的特点上。

The peroxisome proliferator-activated receptors play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipocyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation,eventually lessen ectopic fat accumulation and improve the impaired insulin signaling,so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.

过氧化物酶体增殖物激活受体在脂肪细胞分化、脂肪酸代谢中起重要作用,PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化,从而减少脂质的异位沉积,进一步改善损伤的胰岛素信号转导通路,逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。关键词过氧化物酶体增殖物激活受体;脂肪酸代谢;胰岛素抵抗

A series of N-bonded donor-acceptor derivatives of phenothiazine containing benzene, anisole, pyridine, naphthalene, acetophenone, and benzonitrile as an electron acceptor was synthesized.

合成了一系列的N-10位取代的吩噻嗪给体受体化合物,这些受体包括苯、苯甲醚、吡啶、萘、苯乙酮和苯乙腈。

Biogen recently made a soluble Nogo receptor protein that will bind to all molecules that activate the Nogo receptor.

生物遗传研究公司最近提出了一项可溶性Nogo受体蛋白结合,将所有分子,激活Nogo受体

Research Direction Our research try to block the activation of transmembrane signal transduction related to inflammation by blocking the receptor of cellular membrane.

研究方向细胞内信号转导通路的激活要通过细胞膜受体的介导,本研究拟阻断细胞膜受体的激活,从而阻断肺细胞内各种炎症相关性信号转导通路的激活。

The other 20 cases in control group were treated by antibiotic and alpha-lA receptor blockader.

治疗组应用川参通注射液加口服抗生素、α1A-受体阻滞剂;对照组应用川参通注射液加α1A-受体阻滞剂。

Mature embryos of wheat from cultivar EM12 in Hubei province and mode variety Bobwhite were used as target materials.

以湖北省小麦品种'鄂麦12'和模式品种'Bobwhite'为材料,成熟胚为转化受体,优化基因枪转化法的轰击压力、轰击距离、选择剂等因素,建立以小麦成熟胚为转化受体的高效转化系统。

Week after transplantation surgery, the electron microscopy showed the transplanted REP cells attached to the host"s Bruch"s membrane and survived in contiguity with healthy hosts outer segment.

电镜观察术后7周供体RPE细胞位于受体Bruch膜上并与受体感光细胞外节盘膜形成镶嵌关系。

Objective To investigate the value of the expressions of estrogen receptor and progesterone receptor in the cast-off cells from the fluid of latex ductal lavage in the diagnosis and treatment of breast diseases.

目的:探讨雌激素受体及孕激素受体在乳腺导管内液脱落细胞的表达及其在乳腺疾病诊断及治疗中的意义。

However, pretreatment with CP-101,606 (1 mg/kg), a selective antagonist for the NR2B subunit of the N M D A receptor, significantly attenuated catalepsy and the expression of Fos-IR cells in the forebrain after the administration of haloperidol.

受体拮抗剂BD-1407 (3 mg/kg)and α-1肾上腺素能受体拮抗剂哌唑嗪(3 mg/kg)预处理不能影响氟哌啶醇诱导的强直性木僵和Fos-IR细胞表达。

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